BibTex RIS Kaynak Göster

The relationship between neutrophil to lymphocyte ratio and SYNTAX score in patients with ST-segment elevation myocardial infarction

Yıl 2014, Cilt: 5 Sayı: 2, 211 - 218, 01.06.2014
https://doi.org/10.5799/ahinjs.01.2014.02.0391

Öz

Objective: We aimed to assess relationship between the severity of coronary atherosclerosis assessed by SYNTAX score (SS) and neutrophil to lymphocyte ratio (NLR) in patients with ST elevation myocardial infarction (STEMI. Methods: After accounting for exclusion criteria, a total of 291 patient with STEMI in whom primary percutaneous coronary intervention was performed were retrospectively included (216 male, 75 female; mean age 61.6+14.0 years). Total and differential leukocyte counts and other biochemical markers were measured at admission. Patients were categorized into tertiles on the basis of SS. Monitoring for major adverse cardiac events (MACEs) was performed during the in hospital follow-up period. Results: The SS high group leukocyte (p=0.009), neutrophil (p=0.008), NLR (p=0.048), peak troponin (p

Kaynakça

  • Lopez AD, Mathers CD, Ezzati M, et al. Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet 2006;367:1747-1757.
  • Ertas F, Can Ö, Acet H, Ozbakkaloglu M. The clini- cal significance of anticardiolipin antibody levels in patients with acute myocardial infarction: a regional study. Postep Kardiol Inter 2013;9,4:328–331.
  • Acet H, Ertaş F, Akıl MA, et al. Novel predictor of in- farct-related artery patency before percutaneous in- tervention and in hospital outcomes for STsegment elevation myocardial infarction patients: serum bili- rubin level. Postep Kardiol Inter 2014. DOI: 10.5114/ pwki.2014.41053.
  • Libby P. Inflammation in atherosclerosis. Nature 2002;420:868-874.
  • Hansson GK. Inflammation, atherosclerosis, and coro- nary artery disease. N Engl J Med 2005;352:1685- 1695.
  • Horne BD, Anderson JL, John JM, et al; Intermountain Heart Collaborative Study Group. Which white blood cell subtypes predict increased cardiovascular risk? J Am Coll Cardiol 2005;45:1638-1643.
  • Papa A, Emdin M, Passino C, et al. Predictive value of elevated neutrophil-lymphocyte ratio on cardiac mor- tality in patients with stable coronary artery disease. Clin Chim Acta 2008;395:27-31.
  • Kaya H, Ertas F, Islamoglu Y, et al. Association be- tween neutrophil to lymphocyte ratio and severity of coronary artery disease. Clin Appl Thromb Hemost 2014;20:50-54.
  • Acet H, Ertaş F, Akıl MA. et al. New inflammatory pre- dictors for non-valvular atrial fibrillation: echocardio- graphic epicardial fat thickness and neutrophil to lym- phocyte ratio Int J Cardiovasc Imaging 2014;30:81-89.
  • Nu´n˜ez J, Nu´n˜ez E, Bodı´ V, et al. Usefulness of the neutrophil to lymphocyte ratio in predicting long-term mortality in ST segment elevation myocardial infarc- tion. Am J Cardiol 2008;101:747-752.
  • Serruys PW, Onuma Y, Garg S, et al. Assessment of the SYNTAX score in the Syntax study. EuroInterven- tion 2009;5:50-56.
  • Wykrzykowska JJ, Garg S, Girasis C, et al. Value of the SYNTAX score for risk assessment in the all-com- ers population of the randomized multicenter LEAD- ERS (Limus Eluted from A Durable versus ERodable Stent coating) trial. J Am Coll Cardiol 2010;56:272- 277.
  • Girasis C, Garg S, Raber L, et al. SYNTAX score and Clinical SYNTAX score as predictors of very long-term clinical outcomes in patients undergoing percutane- ous coronary interventions: a substudy of SIRolimus- eluting stent compared with pacliTAXel-eluting stent for coronary revascularization (SIRTAX) trial. Eur Heart J 2011;32:3115-3127.
  • Myocardial infarction redefined: A consensus docu- ment of The Joint European Society of Cardiology/ American College of Cardiology Committee for the redefinition of myocardial infarction. Eur Heart J 2000;21:1502-1513
  • Killip T, Kimball JT. Treatment of myocardial infarction in a coronary care unit. A two year experience with 250 patients. Am J Cardiol 1967;20:457– 464.
  • Sianos G, Morel MA, Kappetein AP, et al. The SYN- TAX Score: an angiographic tool grading the com- plexity of coronary artery disease. EuroIntervention 2005;1:219-227.
  • Gensini GG. A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol 1983;51:606.
  • HoffmanM, Blum A,Baruch R, Kaplan E,Benjamin M. Leukocytes and coronary heart disease. Atheroscle- rosis 2004;172:1-6.
  • Ott I, Neumann FJ, Gawaz M, et al. Increased neu- trophil-platelet adhesion in patients with unstable an- gina. Circulation 1996;94:1239-1246.
  • Maxwell SRJ, Lip GYH. Reperfusion injury: a review of the pathophysiology, clinical manifestations and therapeutic options. Int J Cardiol 1997;58:95-117.
  • Kirtane AJ, Bui A, Murphy SA, et al. Association of peripheral neutrophilia with adverse angiographic outcomes in ST elevation myocardial infarction. Am J Cardiol 2004;93:532-536.
  • Avanzas P, Quiles J, Lopez de Sa E, et al. Neutrophil count and infarct size in patients with acute myocar- dial infarction. Int J Cardiol 2004;97:155-156.
  • Ducloux D, Challier B, Saas P, et al. CD4 cell lympho- penia and atherosclerosis in renal transplant recipi- ents. J Am Soc Nephrol 2003;14:767-772.
  • Onsrud M, Thorsby E. Influence of in vivo hydrocor- tisone on some human blood lymphocyte subpopula- tions. I. Effect on natural killer cell activity. Scand J Immunol 1981;13:573-579.
  • Thomson SP, Gibbons RJ, Smars PA, et al. Incremen- tal value of the leukocyte differential and the rapid cre- atine kinase-MB isoenzyme for the early diagnosis of myocardial infarction. Ann Intern Med 1995;122:335- 341
  • Akpek M, Kaya MG, Lam YY, et al. Relation of neu- trophil/ lymphocyte ratio to coronary flow to in-hospital major adversecardiac events in patients with ST-ele- vated myocardial infarction undergoing primary coro- nary intervention. Am J Cardiol 2012;110:621-627.
  • Sen N, Afsar B, Ozcan F, et al. The neutrophil to lymphocyte ratio was associated with impaired myo- cardial perfusion and long term adverse outcome in patients with ST-elevated myocardial infarction under- going primary coronary intervention. Atherosclerosis 2013;228:203-210.
  • Azab B, Zaher M, Weiserbs KF, et al. Usefulness of neutrophil to lymphocyte ratio in predicting short- and long-term mortality after non-ST-elevation myocardial infarction. Am J Cardiol 2010;106:470-476.
  • Arbel Y FA, Halkin A, Birati EY et al. Neutrophil/lym- phocyte ratio is related to the severity of coronary ar- tery disease and clinical outcome in patients undergo- ing angiography. Atherosclerosis 2012;225:456-460.
  • Polat N, Yildiz A, Yuksel M, et al. Association of Neutro- phil-Lymphocyte Ratio With the Presence and Severity of Rheumatic Mitral Valve Stenosis. Clin Appl Thromb Hemost 2013. DOI: 10.1177/1076029613514131
  • Yildiz A, Oylumlu M, Yuksel M, et al. The Association Between the Neutrophil-to-Lymphocyte Ratio and the Presence of Ventricular Premature Contractions in Young Adults. Clin Appl Thromb Hemost 2013. DOI: 10.1177/1076029613509478
  • Yildiz A, Yuksel M, Oylumlu M, et al. The Utility of the Platelet-Lymphocyte Ratio for Predicting No Re- flow in Patients With ST-Segment Elevation Myocar- dial Infarction Clin Appl Thromb Hemost 2014. DOI: 10.1177/1076029613519851.
  • Oylumlu M, Ozler A, Yildiz A, et al. New inflam- matory markers in pre-eclampsia: echocardio- graphic epicardial fat thickness and neutrophil to lymphocyte ratio. Clin Exp Hypertens 2014. DOI: 10.3109/10641963.2013.863324.
  • Yıldız A, Yüksel M, Oylumlu M, et al. The asso- ciation between the neutrophil/lymphocyte ratio and functional capacity in patients with idiopathic dilated cardiomyopathy. Anadolu Kardiyol Derg 2014. DOI: 10.5152/akd.2014.5131.
  • Yıldız A, Akil MA, Kayan F, et al. Assessment of neu- trophil / lymphocyte ratio in patients with myocardial bridge. J Clin Exp Invest 2014;5:24-28.
  • Çil H, İslamoğluY, Yavuz C. et al. Association between neutrophil/lymphocyte ratio and coronary collateral circulation J Clin Exp Invest 2012;3;29-32.
  • Sahin DY, Elbasan Z, Gür M, et al. Neutrophil to Lymphocyte Ratio Is Associated With the Sever- ity of Coronary Artery Disease in Patients. Angiology 2013;64:423-429.
  • Brkovic V, Dobric M, Beleslin B, et al. Additive prog- nostic value of the SYNTAX score over GRACE, TIMI, ZWOLLE, CADILLAC and PAMI risk scores in patients with acute ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention. Int J Cardiovasc Imaging 2013; 29:1215- 1228.

ST-segment yükselmeli miyokard ınfarktüsünde nötrofil lenfosit oranı ve syntax skoru arasındaki ilişki

Yıl 2014, Cilt: 5 Sayı: 2, 211 - 218, 01.06.2014
https://doi.org/10.5799/ahinjs.01.2014.02.0391

Öz

Amaç: Biz bu çalışmada STEMİ hastalarında nötrofil lenfosit oranı (NLO) ve Syntax skoru (SS) ile değerlendirilen koroner aterosklerozun şiddeti arasındaki ilişkiyi ST yükselmeli miyokard infarktüsü (STEMİ)\'ünde değerlendirmeyi amaçladık. Yöntemler: Dışlama kriterleri sonrası primer perkütan koroner girişim uygulanan geriye dönük olarak toplamda 291 STEMI hastası çalışmaya alındı. (216 erkek,75 kadın, ortalama yaş 61,6±14,0 yıl). Toplam ve diferensiyel lökosit sayımı ve diğer biyokimyasal belirteçler hasta kabulünde alındı. Hastalar SS göre üç tertile ayrıldı. Majör istenmeyen kardiyak olaylar (MİKO) için izleme hastanede yatış döneminde yapıldı Bulgular: SSyüksek grup, lökosit (p=0,009), nötrofil (p=0,008), NLO (p=0,048), zirve troponin (p

Kaynakça

  • Lopez AD, Mathers CD, Ezzati M, et al. Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet 2006;367:1747-1757.
  • Ertas F, Can Ö, Acet H, Ozbakkaloglu M. The clini- cal significance of anticardiolipin antibody levels in patients with acute myocardial infarction: a regional study. Postep Kardiol Inter 2013;9,4:328–331.
  • Acet H, Ertaş F, Akıl MA, et al. Novel predictor of in- farct-related artery patency before percutaneous in- tervention and in hospital outcomes for STsegment elevation myocardial infarction patients: serum bili- rubin level. Postep Kardiol Inter 2014. DOI: 10.5114/ pwki.2014.41053.
  • Libby P. Inflammation in atherosclerosis. Nature 2002;420:868-874.
  • Hansson GK. Inflammation, atherosclerosis, and coro- nary artery disease. N Engl J Med 2005;352:1685- 1695.
  • Horne BD, Anderson JL, John JM, et al; Intermountain Heart Collaborative Study Group. Which white blood cell subtypes predict increased cardiovascular risk? J Am Coll Cardiol 2005;45:1638-1643.
  • Papa A, Emdin M, Passino C, et al. Predictive value of elevated neutrophil-lymphocyte ratio on cardiac mor- tality in patients with stable coronary artery disease. Clin Chim Acta 2008;395:27-31.
  • Kaya H, Ertas F, Islamoglu Y, et al. Association be- tween neutrophil to lymphocyte ratio and severity of coronary artery disease. Clin Appl Thromb Hemost 2014;20:50-54.
  • Acet H, Ertaş F, Akıl MA. et al. New inflammatory pre- dictors for non-valvular atrial fibrillation: echocardio- graphic epicardial fat thickness and neutrophil to lym- phocyte ratio Int J Cardiovasc Imaging 2014;30:81-89.
  • Nu´n˜ez J, Nu´n˜ez E, Bodı´ V, et al. Usefulness of the neutrophil to lymphocyte ratio in predicting long-term mortality in ST segment elevation myocardial infarc- tion. Am J Cardiol 2008;101:747-752.
  • Serruys PW, Onuma Y, Garg S, et al. Assessment of the SYNTAX score in the Syntax study. EuroInterven- tion 2009;5:50-56.
  • Wykrzykowska JJ, Garg S, Girasis C, et al. Value of the SYNTAX score for risk assessment in the all-com- ers population of the randomized multicenter LEAD- ERS (Limus Eluted from A Durable versus ERodable Stent coating) trial. J Am Coll Cardiol 2010;56:272- 277.
  • Girasis C, Garg S, Raber L, et al. SYNTAX score and Clinical SYNTAX score as predictors of very long-term clinical outcomes in patients undergoing percutane- ous coronary interventions: a substudy of SIRolimus- eluting stent compared with pacliTAXel-eluting stent for coronary revascularization (SIRTAX) trial. Eur Heart J 2011;32:3115-3127.
  • Myocardial infarction redefined: A consensus docu- ment of The Joint European Society of Cardiology/ American College of Cardiology Committee for the redefinition of myocardial infarction. Eur Heart J 2000;21:1502-1513
  • Killip T, Kimball JT. Treatment of myocardial infarction in a coronary care unit. A two year experience with 250 patients. Am J Cardiol 1967;20:457– 464.
  • Sianos G, Morel MA, Kappetein AP, et al. The SYN- TAX Score: an angiographic tool grading the com- plexity of coronary artery disease. EuroIntervention 2005;1:219-227.
  • Gensini GG. A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol 1983;51:606.
  • HoffmanM, Blum A,Baruch R, Kaplan E,Benjamin M. Leukocytes and coronary heart disease. Atheroscle- rosis 2004;172:1-6.
  • Ott I, Neumann FJ, Gawaz M, et al. Increased neu- trophil-platelet adhesion in patients with unstable an- gina. Circulation 1996;94:1239-1246.
  • Maxwell SRJ, Lip GYH. Reperfusion injury: a review of the pathophysiology, clinical manifestations and therapeutic options. Int J Cardiol 1997;58:95-117.
  • Kirtane AJ, Bui A, Murphy SA, et al. Association of peripheral neutrophilia with adverse angiographic outcomes in ST elevation myocardial infarction. Am J Cardiol 2004;93:532-536.
  • Avanzas P, Quiles J, Lopez de Sa E, et al. Neutrophil count and infarct size in patients with acute myocar- dial infarction. Int J Cardiol 2004;97:155-156.
  • Ducloux D, Challier B, Saas P, et al. CD4 cell lympho- penia and atherosclerosis in renal transplant recipi- ents. J Am Soc Nephrol 2003;14:767-772.
  • Onsrud M, Thorsby E. Influence of in vivo hydrocor- tisone on some human blood lymphocyte subpopula- tions. I. Effect on natural killer cell activity. Scand J Immunol 1981;13:573-579.
  • Thomson SP, Gibbons RJ, Smars PA, et al. Incremen- tal value of the leukocyte differential and the rapid cre- atine kinase-MB isoenzyme for the early diagnosis of myocardial infarction. Ann Intern Med 1995;122:335- 341
  • Akpek M, Kaya MG, Lam YY, et al. Relation of neu- trophil/ lymphocyte ratio to coronary flow to in-hospital major adversecardiac events in patients with ST-ele- vated myocardial infarction undergoing primary coro- nary intervention. Am J Cardiol 2012;110:621-627.
  • Sen N, Afsar B, Ozcan F, et al. The neutrophil to lymphocyte ratio was associated with impaired myo- cardial perfusion and long term adverse outcome in patients with ST-elevated myocardial infarction under- going primary coronary intervention. Atherosclerosis 2013;228:203-210.
  • Azab B, Zaher M, Weiserbs KF, et al. Usefulness of neutrophil to lymphocyte ratio in predicting short- and long-term mortality after non-ST-elevation myocardial infarction. Am J Cardiol 2010;106:470-476.
  • Arbel Y FA, Halkin A, Birati EY et al. Neutrophil/lym- phocyte ratio is related to the severity of coronary ar- tery disease and clinical outcome in patients undergo- ing angiography. Atherosclerosis 2012;225:456-460.
  • Polat N, Yildiz A, Yuksel M, et al. Association of Neutro- phil-Lymphocyte Ratio With the Presence and Severity of Rheumatic Mitral Valve Stenosis. Clin Appl Thromb Hemost 2013. DOI: 10.1177/1076029613514131
  • Yildiz A, Oylumlu M, Yuksel M, et al. The Association Between the Neutrophil-to-Lymphocyte Ratio and the Presence of Ventricular Premature Contractions in Young Adults. Clin Appl Thromb Hemost 2013. DOI: 10.1177/1076029613509478
  • Yildiz A, Yuksel M, Oylumlu M, et al. The Utility of the Platelet-Lymphocyte Ratio for Predicting No Re- flow in Patients With ST-Segment Elevation Myocar- dial Infarction Clin Appl Thromb Hemost 2014. DOI: 10.1177/1076029613519851.
  • Oylumlu M, Ozler A, Yildiz A, et al. New inflam- matory markers in pre-eclampsia: echocardio- graphic epicardial fat thickness and neutrophil to lymphocyte ratio. Clin Exp Hypertens 2014. DOI: 10.3109/10641963.2013.863324.
  • Yıldız A, Yüksel M, Oylumlu M, et al. The asso- ciation between the neutrophil/lymphocyte ratio and functional capacity in patients with idiopathic dilated cardiomyopathy. Anadolu Kardiyol Derg 2014. DOI: 10.5152/akd.2014.5131.
  • Yıldız A, Akil MA, Kayan F, et al. Assessment of neu- trophil / lymphocyte ratio in patients with myocardial bridge. J Clin Exp Invest 2014;5:24-28.
  • Çil H, İslamoğluY, Yavuz C. et al. Association between neutrophil/lymphocyte ratio and coronary collateral circulation J Clin Exp Invest 2012;3;29-32.
  • Sahin DY, Elbasan Z, Gür M, et al. Neutrophil to Lymphocyte Ratio Is Associated With the Sever- ity of Coronary Artery Disease in Patients. Angiology 2013;64:423-429.
  • Brkovic V, Dobric M, Beleslin B, et al. Additive prog- nostic value of the SYNTAX score over GRACE, TIMI, ZWOLLE, CADILLAC and PAMI risk scores in patients with acute ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention. Int J Cardiovasc Imaging 2013; 29:1215- 1228.
Toplam 38 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Araştırma Yazısı
Yazarlar

Halit Acet Bu kişi benim

Faruk Ertaş Bu kişi benim

Yayımlanma Tarihi 1 Haziran 2014
Yayımlandığı Sayı Yıl 2014 Cilt: 5 Sayı: 2

Kaynak Göster

APA Acet, H., & Ertaş, F. (2014). ST-segment yükselmeli miyokard ınfarktüsünde nötrofil lenfosit oranı ve syntax skoru arasındaki ilişki. Journal of Clinical and Experimental Investigations, 5(2), 211-218. https://doi.org/10.5799/ahinjs.01.2014.02.0391
AMA Acet H, Ertaş F. ST-segment yükselmeli miyokard ınfarktüsünde nötrofil lenfosit oranı ve syntax skoru arasındaki ilişki. J Clin Exp Invest. Haziran 2014;5(2):211-218. doi:10.5799/ahinjs.01.2014.02.0391
Chicago Acet, Halit, ve Faruk Ertaş. “ST-Segment yükselmeli Miyokard ınfarktüsünde nötrofil Lenfosit Oranı Ve Syntax Skoru arasındaki ilişki”. Journal of Clinical and Experimental Investigations 5, sy. 2 (Haziran 2014): 211-18. https://doi.org/10.5799/ahinjs.01.2014.02.0391.
EndNote Acet H, Ertaş F (01 Haziran 2014) ST-segment yükselmeli miyokard ınfarktüsünde nötrofil lenfosit oranı ve syntax skoru arasındaki ilişki. Journal of Clinical and Experimental Investigations 5 2 211–218.
IEEE H. Acet ve F. Ertaş, “ST-segment yükselmeli miyokard ınfarktüsünde nötrofil lenfosit oranı ve syntax skoru arasındaki ilişki”, J Clin Exp Invest, c. 5, sy. 2, ss. 211–218, 2014, doi: 10.5799/ahinjs.01.2014.02.0391.
ISNAD Acet, Halit - Ertaş, Faruk. “ST-Segment yükselmeli Miyokard ınfarktüsünde nötrofil Lenfosit Oranı Ve Syntax Skoru arasındaki ilişki”. Journal of Clinical and Experimental Investigations 5/2 (Haziran 2014), 211-218. https://doi.org/10.5799/ahinjs.01.2014.02.0391.
JAMA Acet H, Ertaş F. ST-segment yükselmeli miyokard ınfarktüsünde nötrofil lenfosit oranı ve syntax skoru arasındaki ilişki. J Clin Exp Invest. 2014;5:211–218.
MLA Acet, Halit ve Faruk Ertaş. “ST-Segment yükselmeli Miyokard ınfarktüsünde nötrofil Lenfosit Oranı Ve Syntax Skoru arasındaki ilişki”. Journal of Clinical and Experimental Investigations, c. 5, sy. 2, 2014, ss. 211-8, doi:10.5799/ahinjs.01.2014.02.0391.
Vancouver Acet H, Ertaş F. ST-segment yükselmeli miyokard ınfarktüsünde nötrofil lenfosit oranı ve syntax skoru arasındaki ilişki. J Clin Exp Invest. 2014;5(2):211-8.