Recurrent Guillain-Barré syndrome associated with idiopathic thrombocytopenic purpura

Yıl 2012, Cilt: 3 Sayı: 2, 284 - 286, 01.06.2012

Süber Dikici Gülşen Kocaman Hatice Gümüş Ayhan Öztürk

https://doi.org/10.5799/ahinjs.01.2012.02.0162

Öz

Guillain-Barré syndrome (GBS) usually present with acute inflammatory polyradiculoneuropathy having clinical features of rapid and progressive weakness at the limbs, symmetric decrease or loss of tendon reflexes. The exact mechanism of clinical picture is not well known but immune factors are blamed. Patients having GBS have an recurrence rate ranging between 1% and 10%. Idiopathic thrombocytopenic purpura (ITP) is an acquired systemic disease presented with mild to severe thrombocytopenia. The patient who followed with ITP diagnosis for 12 years underwent 2 times GBS attacks within 2-year interval. We would like to present this case due to rare association of ITP diagnosis & GBS attacks. J Clin Exp Invest 2012; 3(2): 284-286

Anahtar Kelimeler

Guillain-Barré syndrome, Idiopathic thrombocytopenic purpura, recurrent.

Recurrent Guillain-Barré syndrome associated with idiopathic thrombocytopenic purpura

Öz

Guillain-Barré sendromu (GBS), genellikle hızlı ve ilerleyici giden, asendan simetrik kuvvet kaybı ve arefleksi ile karakterize akut enflamatuar polinradikülonöropatidir. Klinik tablonun gelişim mekanizması tam olarak bilinmemekle birlikte immun faktörler suçlanmaktadır. GBS geçiren hastaların %1-10\'unda tekrarlama ihtimali vardır. İdiyopatik trombositopenik purpura (İTP), ortadan şiddetliye kadar değişebilen trombositopeninin eşlik ettiği edinsel sistemik bir hastalıktır. 12 yıldır İTP tanısıyla takip edilirken, 2 yıl arayla GBS geçiren olgu nadir gözlendiği için sunulacaktır.

Anahtar Kelimeler

Guillain-Barré sendromu, idiyopatik trombositopenik purpura, tekrarlayan

Kaynakça

• Winer JB. Guillain-Barré Syndrome. J Clin Pathol Mol Pathol 2001;54(2):381-5.
• Hughes RAC, Rees JH. Clinical and epidemiologic features of Guillain-Barré syndrome.Clin Infect Dis 1997;176(Suppl 2):S92-S98.
• Pithadia AB, Kakadia N. Guillain-Barré syndrome (GBS). Pharmacol Rep 2010;62(2):220-32.
• Baba M, Matsunaga M, Narita S, Liu H. Recurrent Guil- lain-Barré syndrome in Japan. Intern Med 1995;34: 1015-8.
• Combes A, Goulon M. Recurrence of Guillain-Barré syndrome. Ann Med Interne (Paris) 1992; 143: 515-8.
• Kuitwaard K, van Koningsveld R, Ruts L, Jacobs BC, van Doorn PA. Recurrent Guillain-Barré syndrome. J Neurol Neurosurg Psychiatry 2009;80(1):56-9.
• Gernsheimer T. Chronic idiopathic thrombocytopenic purpura: Mechanisms of Pathogenesis. Oncologist 2009;14(1):12–21
• Khaldi F, Larnaout A, Miladi N, Bennaceur B. Guillain- Barré syndrome and idiopathic thrombocytopenic pur- pura. Can J Neurol Sci 1990;17(1):95-6.
• Combarros O, Calleja J, Hernández L, Polo JM, Ber- ciano J. Guillain-Barré syndrome associated with idio- pathic thrombocytopenic purpura. J Neurol Neurosurg Psychiatry 1991;54(7):654-5.