Öz
Vitamin B12 deficiency may cause psychiatric manifestations preceding the hematological and neurological symptoms. Despite a variety of symptoms, data on the role of vitamin B12 deficiency in depression are sparse. We report a case with B12 deficiency that is diagnosed with psychotic depression and treated successively with vitamin B12 replacement instead of using conventional therapy. Future investigations should focus on the role of vitamin B12 status in depression and other neuropsychiatric disorders. J Clin Exp Invest 2011; 2 (4): 455-456
Anahtar Kelimeler
Kaynakça
- Herrmann W, Lorenzl S, Obeid R. Review of the role of hyperhomocysteinemia and B-vitamin deficiency in neurological and psychiatric disorders: current evidence and preliminary recommendations. Fortschr Neurol Psychiatr 2007; 75(9):515–27.
- Bottiglieri T, Laundy M, Crellin R, et al. Homocysteine, folate, methylation and monoamine metabolism in depression. J Neurol Nerosurg Psychiatry 2000; 69(2):228–32.
- Penninx BW, Guralnik JM, Ferrucci L, et al. Vitamin B(12) deficiency and depression in physically dis- abled older women: epidemiologic evidence from the Women’s Health and Aging Study. Am J Psychiatry 2000; 157(5):715–21.
- Baik HW, Russell RM. Vitamin B12 deficiency in the elderly. Annu Rev Nutr 1999; 19(1):357–77.
- Güzelcan Y, Van Loon P. Vitamin B12 status in patients of Turkish and Dutch descent with depression: a com- parative cross-sectional study. Ann Gen Psychiatry 2009; 8(1):18-22.
- Mischoulon D, Burger JK, Spillmann MK, Worthington JJ, Fava M, Alpert JE. Anemia and macrocytosis in the prediction of serum folate and vitamin B12 status, and treatment outcome in major depression. J Psy- chosom Res 2000; 49(3):183–7.
- Hintikka J, Tolmunen T, Tanskanen A, Viinamaki H. High vitamin B12 level and good treatment outcome may be associated in major depressive disorder. BMC Psychiatry 2003; 3(1):17-8.
Öz
B12 vitamin eksikliği, hematolojik ve nörolojik semptomlardan önce psikiyatrik tablolara neden olabilmektedir. Pek çok semptoma rağmen B12 vitamin eksikliğinin depresyondaki rolü ile ilgili veriler nadirdir. Biz, psikotik depresyon tanısı konulan, konvansiyonel tedavi yerine B12 replasmanı ile başarılı bir şekilde tedavi edilen B12 vitamin eksikliği olan bir vakayı sunuyoruz. Gelecekteki araştırmalar, B12 vitamininin depresyon ve diğer nöropsikiyatrik bozukluklar üzerindeki etkilerine odaklanmalıdır.
Anahtar Kelimeler
Kaynakça
- Herrmann W, Lorenzl S, Obeid R. Review of the role of hyperhomocysteinemia and B-vitamin deficiency in neurological and psychiatric disorders: current evidence and preliminary recommendations. Fortschr Neurol Psychiatr 2007; 75(9):515–27.
- Bottiglieri T, Laundy M, Crellin R, et al. Homocysteine, folate, methylation and monoamine metabolism in depression. J Neurol Nerosurg Psychiatry 2000; 69(2):228–32.
- Penninx BW, Guralnik JM, Ferrucci L, et al. Vitamin B(12) deficiency and depression in physically dis- abled older women: epidemiologic evidence from the Women’s Health and Aging Study. Am J Psychiatry 2000; 157(5):715–21.
- Baik HW, Russell RM. Vitamin B12 deficiency in the elderly. Annu Rev Nutr 1999; 19(1):357–77.
- Güzelcan Y, Van Loon P. Vitamin B12 status in patients of Turkish and Dutch descent with depression: a com- parative cross-sectional study. Ann Gen Psychiatry 2009; 8(1):18-22.
- Mischoulon D, Burger JK, Spillmann MK, Worthington JJ, Fava M, Alpert JE. Anemia and macrocytosis in the prediction of serum folate and vitamin B12 status, and treatment outcome in major depression. J Psy- chosom Res 2000; 49(3):183–7.
- Hintikka J, Tolmunen T, Tanskanen A, Viinamaki H. High vitamin B12 level and good treatment outcome may be associated in major depressive disorder. BMC Psychiatry 2003; 3(1):17-8.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Olgu Sunumu |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Aralık 2011 |
| Yayımlandığı Sayı | Yıl 2011 Cilt: 2 Sayı: 4 |