Relationships between anthropometric measurements, leptin and IGF-1 levels in Turkish healthy newborns

Yıl 2015, Cilt: 6 Sayı: 3, 214 - 219, 25.10.2015

Sacide Karakaş Ayfer Tellioğlu , Güzel Dişcigil Aslıhan B. Karul Münevver Türkmen

https://doi.org/10.5799/ahinjs.01.2015.03.0521

Cited By: 1

Öz

Objective: The aim of the present study is to determine anthropometric measurements of a group of healthy newborns and evaluate their association with the serum levels of leptin and insulin-like growth factor 1(IGF-1).

Methods: Extremity lengths, skinfold thickness, body circumference measurements of 113 heathy newborns were taken by appropriate methods. Of the total 113 newborns, 55 were male and 58 were female. Serum leptin and IGF-1 levels were measured.

Results: Leptin levels had moderately positive correlations with body mass index (BMI), weight and suprailiac skinfold thickness (p<0.05). There was no significant relationship between anthropometric measurements and IGF-1 levels (p>0.05).

Conclusion: Anthropometric measurements of newborns will be of guidance for the growth and development of their future life. J Clin Exp Invest 2015; 6 (3): 214-219

Key words: Anthropometry, newborn, leptin, insulin-like growth factor 1(IGF-1)

Anahtar Kelimeler

Anthropometry, newborn, leptin, insulin-like growth factor 1(IGF-1)

Sağlıklı Türk yenidoğanlarda antropometrik ölçümlerin leptin ve IGF-1 seviyeleriyle ilişkisi

Öz

Amaç: Bu çalışmanın amacı, sağlıklı yenidoğanların antropometrik ölçümlerini yapmak ve ölçümlerin serum leptin ve insulin benzeri büyüme faktörü 1(IGF-1) düzeyleriyle ilişkisini araştırmaktır.Yöntemler: Toplam 113(55 erkek, 58 kız) sağlıklı yenidoğanda, ekstremite uzunlukları, deri kıvrım kalınlığı, vücut çevre ölçümleri uygun yöntemler kullanılarak ölçüldü. Serum leptin ve IGF-1 seviyelerine bakıldı.Bulgular: Antropometrik ölçümlerden vücut kitle indeksi, vücut ağırlığı ve suprailiac deri kıvrım kalınlığı ile serum leptin seviyesi arasında orta düzeyde pozitif korelasyon saptandı (p<0.05). IGF seviyesi ve antropometrik ölçüm sonuçları arasında anlamlı bir ilişki saptanmadı (p>0.05).Sonuç: Bebeklerin antropometrik ölçümleri gelecekteki büyüme ve gelişme düzeyleri konusunda rehberlik edecektir. Leptin büyüme üzerine etkili bir hormondur

Anahtar Kelimeler

antropometri, yenidoğan, leptin, insulin benzeri büyüme faktörü 1(IGF-1)

Kaynakça

• Hayran O. Çocuklarda beslenme ve büyümenin değerlendirilmesi
• açısından antropometrik ölçümlerin anlamı ve yorumu. Beslenme ve Diet Dergisi 1990;19:237-243.
• Madhulika Kabra SK, Barar V, Puriot A et al. Upper and lower limb standards in newborn. Indian Pediatr 1989;26:667–670.
• Puliyel JM. Upper and Lower Limb Standards in Newborns. Indian Pediatr 1990;27:643–645.
• Schmelzle HR, Fusch C. Body fat in neonates and young ınfants: validation of skinfold thickness versus dual-energy x-ray absorptiometry. Am J Clin Nutr 2002;76:1096-1100.
• WHO. Physical Status: The Use and Interpretation of Anthropometry. Report of a Technical Committee. GenevaTechnical
• Report Series 1995; No:854.
• Tung WK, Lin SJ, Hwang YS, et al. Association of cord plasma leptin with birth size in term newborns. Pediatr Neonatol 2009;50:255-260.
• Tsai PJ, Yu CH, Hsu SP, et al. Cord plasma concentrations of adiponectin and leptin in healthy term neonates: positive correlation with birthweight and neonatal adiposity. Clinical Endocrinol 2004;61:88–93.
• Ong K, Kratzsch J, Kiess W, et al. Circulating IGF-I levels in childhood are related to both current body composition and early postnatal growth rate. J Clin Endocrinol Metab 2002;87:1041-1044.
• Yüksel B, Özbek MN, Mungan NÖ, et al. Serum IGF-1 and IGFBP-3 levels in healthy children between 0 and 6 years of age. J Clin Res Pediatr Endocrinol 2011;3:84-88.
• Nasr MR, Ebrahim NA, Ramadan MS, et al. Growth pattern in children with beta-thalassemia major and its relation with serum ferritin, IGF1 and IGFBP3. J Clin Exp Invest 2012;3:157-163.
• Hall JG, Foster Iskenius UG, Allanson JE. Handbook Of Normal Physical Measurements, New York: Oxford University Press, 1989.
• Heyward VH, Atolarczyk LM. Applied Body Composition Assessment. Champaign: Human Kinetics, 1996:1-221
• Yoshioka T, Kawada K, Shimada T, et al. Lipid peroxidation in maternal and cord blood and protective mechanism against activated-oxygen toxicity in the blood. Am J Obstet Gynecol 1979;135:372-376.
• Kratsch J, Schubring C, Stitzel B, et al. Inverse changes in the serum levels of the soluble leptin receptor and leptin in neonates- relations to anthropometric data. J Clin Endocrinol Metab 2005;90:2212-2217.
• Yildiz L, Avci B, Ingeç M. Umbilical cord and maternal blood leptin concentrations in ıntrauterine growth retardation. Clin Chem Lab Med 2002;40:1114-1117.
• Yeung LP, Wong AC, Wang X, et al. Different relationship between anthropometric markers and umbilical cord plasma leptin in asian and caucasian neonates. Pediatr Res 2003;53:1019-1024.
• Savino F, Fissore MF, Grassino EC, et al. Ghrelin, leptin and IGF-1 in breast-fed and formula-fed infants in the first years of life. Acta Paediatr 2005;94:531-537.
• LakhoGR, Haq Z, Chundrigar T, et al. Cord blood leptin levels in Pakistani newborns: relationship with birth weight, length and occipitofrontal circumference. J Coll Physicians Surg Pak 2006;16:393-395.
• Christou H, Connors JM, Ziotopoulou M, et al. Cord blood leptin and ınsulin–like growth factor levels are ındependet predictors of fetal growth. J Clin Endocrinol Metab 2001;86:935-938.
• Cho GJ, Yoo SW, Hong SC, et al. Correlations between umbilical and maternal serum resistin levels and neonatal birth weight.Acta Obstet Gynecol Scand 2006;85:1051-1056.
• Pathmaperuma AN, Tennekoon KH, Senanayake L, et al. Maternal and cord blood levels of insulin-like growth factors-I and-II and insulin-like growth factor binding protein-1: correlation with birth weight and maternal anthropometric indices. Ceylon Med J 2007;52:48-52.
• Tennekoon KH, Poopalapillai J, Karunanayake AG, et al. Association of cord blood leptin, soluble leptin receptor, insulin-like growth factor-I and insulinlike growth factor-binding protein-1 on birth indices in healthy full term newborns. Horm Res Paediatr
• ;81:232-238.
• Rohrmann S, Sutcliffe CG, Bienstock JL, et al. Racial variation in sex steroid hormones and the insulin-like growth factor axis in umbilical cord blood of male neonates. Cancer Epidemiol Biomarkers Prev 2009;18:1484-1491.
• Taeusch H W. Initial Evaluations: History and Physical Examination of Newborn. In: Taeusch HW, Ballord RA, Avery ME. Diseases of Newborn. Philadelphia. W.B. Saunders Company 1991:207-224.
• Fok TF, Hon KL, Wong E, et al. Trunk Anthropometry of Hong Kong Chinese Infants. Early Hum Dev 2005;81:781-790.
• Halder D, Dharap AS, Than M. Normal values for total hand length, palm length and middle finger length in malaysian newborns from 34-42 weeks of gestation. Anthropol Anz 1999;57:69-75.
• Laccerda, C. A. M. Foot length growth related to crown-rump ength gestational age and weigth in human staged fresh fetuses. Surg Radiol Anatomy 1990;12:103-107.
• Sreeramareddy CT, Chuni N, Patil R,et al. Anthropometric
• surrogate to ıdentify low birth weight nepalese newborns: a hospital-based study. BMC Pediatrics 2008;8:1-8.
• Samal GC, Swain AK. Calf circumference as an alternative to birth weight for ıdentification of low birth weight babies. Indian Pediatrics 2001;38:275-277.
• Ahmed FU, Karim E, Bhuiyan SN. Mid-arm circumference at birth as predictor of low birth weight and neonatal mortality. J Biosoc Sci 2000;32:487-493.
• Das JC, Afroze A, Khanam ST, et al. Mid-arm circumference:an alternative measure for screening low birth weight babies. Bangladesh Med Res Counc Bull 2005;31:1-6.
• Iroha EO, Ezeaka VC, Akinsulie AO, et al. Maternal HIV ınfection and ıntrauterine growth: a prospective study in Lagos, Nigeria. West Afr J Med 2007;26:121-125.
• Şehla İhsan. 9-72 aylık çocuklarda antropometrik ölçümler ve antropometrik ölçümlere etki eden parametrelerin araştırılması. Uzmanlık Tezi, T.C. SağlıkBakanlığı Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi, İstanbul,2006:1-84.
• Rodriguez G, Samper M, Olivares J, et al. Skinfold measurements at birth: sex and anthropometric influence. Arch Dis Child Fetal Neonatal Ed 2005;90:273-275.
• Guihard-Costa A M, Grange G, Larroche JC, et al. Sexual differences in anthropometric measurements in French newborns. Biol Neonate 1997;72:156-164.
• Shah D, Sachdev HP, Gupta R, et al. Secular change in newborn adiposity in an urban hospital. Indian Pediatrics 2004;41:1-5.