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Effects of intra articular tramadol on articular cartilage and synovium of rats

Yıl 2015, Cilt: 6 Sayı: 4, 337 - 342, 03.01.2016
https://doi.org/10.5799/ahinjs.01.2015.04.0546

Öz

Objective: To investigate the effects of intra articular tramadol injection on articular cartilage and synovium in rat knee joint.

Methods: After Animal Ethical Committee approval, a total of 20 Sprague-Dawley rats were used and divided into 4 groups. Each group was composed of 5 rats. 0.2 ml of tramadol HCl was injected into the right knee joints and left knee joints of all the rats were considered as control. Control side joints received saline injection. Rats were sacrificed with ketamin on 1st, 7th, 14th and 21st days and knee joints were removed. Obtained tissue samples were decalcified and were dyed with Hematoxylin-eosin and Masson’s trichrome stain and examined by light microscopy for the presence of inflammation in periarticular area and synovia.

Results: Congestion of synovial veins and perivascular cell infiltration were observed in tramadol group on days 1 and 7 (P < 0.05). The inflammation process was replaced by fibrosis on day 14 and fibrosis was significantly decreased on day 21.

Conclusion: Intra articular tramadol should be used cautiously, keeping in mind that it may cause synovial inflammation in early phases and fibrosis in late phases. J Clin Exp Invest 2015; 6 (4): 337-342

Key words: Analgesics, opioid, tramadol, rat, hyaline cartilage, arthroscopy

Kaynakça

  • McLoughlin C, McKinney MS, Fee J, et al. Diclofenac for day-care arthroscopy surgery: comparison with a standard opioid therapy. Br J Anaesth 1990;65:620-623.
  • Calmet J, Esteve C, Boada S, et al. Analgesic effect of intra articular ketorolac in knee arthroscopy: Comparison of morphine and bupivacaine. Knee Surg Sports Traumatol Arthrosc 2004;12:552-555.
  • Badner NH, Bourne RB, Rorabeck CH, et al. Intra articular
  • injection of bupivacaine in knee-replacement operations. Results of use for analgesia and for preemptive blockade. J Bone Surg 1996;78:734-738.
  • Moiniche S, Mikkelsen S, Wetterslev J, et al. A systematic review of intra articular local anesthesia for postoperative pain relief after arthroscopic knee surgery. Reg Anesth Pain Med 1999;24:430-437.
  • Convery PN, Milligan KR, Ouinn P, et al. Low-dose intra articular ketorolac for pain relief following arthroscopy of the knee joint. Anaesthesia 1998;53:1125-1129.
  • Tuncer B, Babacan CA, Arslan M. The pre-emptive analgesic effect of intra articular bupivacaine in arthroscopic knee surgery. Acta Anaesthesiol Scand 2005;49:1373-1377.
  • Reuben SS, Connelly NR. Postoperative analgesia for outpatient arthroscopic knee surgery with intra articular bupivacaine and ketorolac. Anesth Analg 1995;80:1154-1157.
  • Rosseland LA, Stubhaug A, Skoglund A, et al. Intra articular
  • morphine for pain relief after knee arthroscopy. Acta Anaesthesiol Scand 1999;43:252-257.
  • Saricaoglu F, Dal D, Atilla P, et al. Effect of intra articular
  • injection of lornoxicam on the articular cartilage & synovium in rat. Indian J Med Res 2008;127:367-370.
  • Denti M, Randelli P, Bigoni M, et al. Pre and postoperative intra articular analgesia for arthroscopic surgery of the knee and arthroscopy assisted anterior cruiciate ligament reconstruction. A double-blind randomized, prospective study. Knee Surg Sports Traumatol Arthrosc 1997;5:206-212.
  • Irwin MG, Cheung KMC, Nicholls JM, et al. Intra articular injection of ketorolac in the rat knee-joint: Effect on articular cartilage and synovium. Br J Anaesth 1998;80:837-839.
  • Fujii K, Tajiri K, Kajiwara T, et al. Effects of NSAID on collagen and proteoglycan synthesis of cultured chondrocytes. Br J Rheumatol Suppl 1989;18:28-31.
  • Romsing J, Moiniche S, Ostergaard D, et al. Local infiltration with NSAIDs for postoperative analgesia: Evidence for a peripheral analgesic action. Acta Anaesthesiol Scand 2000:44:672-683.
  • Kayhan Z. Klinik Anestezi. Logos Yayıncılık, Genişletilmiş üçüncü baskı, Ankara, 2004,p.106-107.
  • Alagöl A, Çalpur OU, Kaya G, et al. The use of intra articular tramadol for postoperative analgesia after arthroscopic knee surgery: a comparison of different intra articular and intravenous doses. Knee Surg Sports Traumatol Arthrosc 2004;12:184-188.
  • Likar R, Masthiaschitz K, Burtscher M, et al. Randomized-doubled-blind, comparative study of morphine and tramadol administered intraarticulary for postoperative analgesia following arthroscopic surgery. Clin Drug Invest 1995;10:10–17.
  • Garlicki J, Dorazil-Dudzik M, Wordliczek J, et al. Effect of intraarticular tramadol administration in the rat model of knee joint inflammation. Pharmacological Reports 2006;58:672-679.
  • Rahmat A. Fatahian Dehkordi RAF, Bigham-Sadegh A, Vajd N. The effects of intra-articular tramadol administration on histopathological indices in rat knee joint. Veterinarski Arhiv 2014;84:667-676.
  • Zimmermann M: Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983;16:109–110.
  • David MJ, Vignon E, Peschard MJ, et al. Effect of NSAIDs on glycosiltransferase activity from human osteoarthritic cartilage. Br J Rheumatol 1992;31:13-17.
  • Ozyuvacı H, Bilgic B, Ozyuvacı E, et al. Intra articular injection of tenoxicam in rats: assessment of the local effects on the articular cartilage and synovium. J Int Med Res 2004;32:312-316.
  • Balabanova RM, Fedina TP, Tsurko VV, et al. Dynamic
  • changes in synovitis activity after intra articular administration
  • of xefocam in patients with rheumatoid arthritis (according to clinical and device examinations). Ter Arkh 2003;75:33-35.

Eklem içine verilen tramadolün eklem kartilaj ve sinovyuma etkileri

Yıl 2015, Cilt: 6 Sayı: 4, 337 - 342, 03.01.2016
https://doi.org/10.5799/ahinjs.01.2015.04.0546

Öz

Amaç: Fare diz eklemine yapılan tramadolün kıkırdak ve sinovyuma etkilerinin incelenmesiYöntemler: Hayvan Etik Komite onayı alındıktan sonra, toplam 20 Sprague-Dawley fare dört eşit gruba ayrıldı. 0.2 ml tramadol HCl hayvanların sağ diz eklemine enjekte edildi ve sol dizler kontrol olarak kabul edildi. Kontrol tarafındaki eklemlere serum fizyolojik enjeksiyonu yapıldı. Birinci, 7., 14. ve 21. Günlerde ölümcül doz ketamin ile hayvanlar sakrifiye edilerek eklemler histopatolojik inceleme için çıkarıldı. Elde edilen doku örnekleri dekalsifiye edildikten sonra Hematoxilen-Eosin ve Masson’s trichrome boyası ile boyandı, periartikülar ve sinovyum çevresinde inflamasyon olup olmadığını araştırmak için ışık mikroskopu ile incelendi.Bulgular: 1. ve 7. gün tramadol grubunda sinovyal damarlarda genişleme ve perivasküler hücre infiltrasyonu gözlendi (p

Kaynakça

  • McLoughlin C, McKinney MS, Fee J, et al. Diclofenac for day-care arthroscopy surgery: comparison with a standard opioid therapy. Br J Anaesth 1990;65:620-623.
  • Calmet J, Esteve C, Boada S, et al. Analgesic effect of intra articular ketorolac in knee arthroscopy: Comparison of morphine and bupivacaine. Knee Surg Sports Traumatol Arthrosc 2004;12:552-555.
  • Badner NH, Bourne RB, Rorabeck CH, et al. Intra articular
  • injection of bupivacaine in knee-replacement operations. Results of use for analgesia and for preemptive blockade. J Bone Surg 1996;78:734-738.
  • Moiniche S, Mikkelsen S, Wetterslev J, et al. A systematic review of intra articular local anesthesia for postoperative pain relief after arthroscopic knee surgery. Reg Anesth Pain Med 1999;24:430-437.
  • Convery PN, Milligan KR, Ouinn P, et al. Low-dose intra articular ketorolac for pain relief following arthroscopy of the knee joint. Anaesthesia 1998;53:1125-1129.
  • Tuncer B, Babacan CA, Arslan M. The pre-emptive analgesic effect of intra articular bupivacaine in arthroscopic knee surgery. Acta Anaesthesiol Scand 2005;49:1373-1377.
  • Reuben SS, Connelly NR. Postoperative analgesia for outpatient arthroscopic knee surgery with intra articular bupivacaine and ketorolac. Anesth Analg 1995;80:1154-1157.
  • Rosseland LA, Stubhaug A, Skoglund A, et al. Intra articular
  • morphine for pain relief after knee arthroscopy. Acta Anaesthesiol Scand 1999;43:252-257.
  • Saricaoglu F, Dal D, Atilla P, et al. Effect of intra articular
  • injection of lornoxicam on the articular cartilage & synovium in rat. Indian J Med Res 2008;127:367-370.
  • Denti M, Randelli P, Bigoni M, et al. Pre and postoperative intra articular analgesia for arthroscopic surgery of the knee and arthroscopy assisted anterior cruiciate ligament reconstruction. A double-blind randomized, prospective study. Knee Surg Sports Traumatol Arthrosc 1997;5:206-212.
  • Irwin MG, Cheung KMC, Nicholls JM, et al. Intra articular injection of ketorolac in the rat knee-joint: Effect on articular cartilage and synovium. Br J Anaesth 1998;80:837-839.
  • Fujii K, Tajiri K, Kajiwara T, et al. Effects of NSAID on collagen and proteoglycan synthesis of cultured chondrocytes. Br J Rheumatol Suppl 1989;18:28-31.
  • Romsing J, Moiniche S, Ostergaard D, et al. Local infiltration with NSAIDs for postoperative analgesia: Evidence for a peripheral analgesic action. Acta Anaesthesiol Scand 2000:44:672-683.
  • Kayhan Z. Klinik Anestezi. Logos Yayıncılık, Genişletilmiş üçüncü baskı, Ankara, 2004,p.106-107.
  • Alagöl A, Çalpur OU, Kaya G, et al. The use of intra articular tramadol for postoperative analgesia after arthroscopic knee surgery: a comparison of different intra articular and intravenous doses. Knee Surg Sports Traumatol Arthrosc 2004;12:184-188.
  • Likar R, Masthiaschitz K, Burtscher M, et al. Randomized-doubled-blind, comparative study of morphine and tramadol administered intraarticulary for postoperative analgesia following arthroscopic surgery. Clin Drug Invest 1995;10:10–17.
  • Garlicki J, Dorazil-Dudzik M, Wordliczek J, et al. Effect of intraarticular tramadol administration in the rat model of knee joint inflammation. Pharmacological Reports 2006;58:672-679.
  • Rahmat A. Fatahian Dehkordi RAF, Bigham-Sadegh A, Vajd N. The effects of intra-articular tramadol administration on histopathological indices in rat knee joint. Veterinarski Arhiv 2014;84:667-676.
  • Zimmermann M: Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983;16:109–110.
  • David MJ, Vignon E, Peschard MJ, et al. Effect of NSAIDs on glycosiltransferase activity from human osteoarthritic cartilage. Br J Rheumatol 1992;31:13-17.
  • Ozyuvacı H, Bilgic B, Ozyuvacı E, et al. Intra articular injection of tenoxicam in rats: assessment of the local effects on the articular cartilage and synovium. J Int Med Res 2004;32:312-316.
  • Balabanova RM, Fedina TP, Tsurko VV, et al. Dynamic
  • changes in synovitis activity after intra articular administration
  • of xefocam in patients with rheumatoid arthritis (according to clinical and device examinations). Ter Arkh 2003;75:33-35.
Toplam 27 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Araştırma Yazısı
Yazarlar

Musa Kola Bu kişi benim

Sennur Uzun Bu kişi benim

Naciye Zeybek Bu kişi benim

Fatma Sarıcaoğlu Bu kişi benim

Seda Akıncı Bu kişi benim

Ülkü Aypar Bu kişi benim

Esin Asan Bu kişi benim

Yayımlanma Tarihi 3 Ocak 2016
Yayımlandığı Sayı Yıl 2015 Cilt: 6 Sayı: 4

Kaynak Göster

APA Kola, M., Uzun, S., Zeybek, N., Sarıcaoğlu, F., vd. (2016). Effects of intra articular tramadol on articular cartilage and synovium of rats. Journal of Clinical and Experimental Investigations, 6(4), 337-342. https://doi.org/10.5799/ahinjs.01.2015.04.0546
AMA Kola M, Uzun S, Zeybek N, Sarıcaoğlu F, Akıncı S, Aypar Ü, Asan E. Effects of intra articular tramadol on articular cartilage and synovium of rats. J Clin Exp Invest. Ocak 2016;6(4):337-342. doi:10.5799/ahinjs.01.2015.04.0546
Chicago Kola, Musa, Sennur Uzun, Naciye Zeybek, Fatma Sarıcaoğlu, Seda Akıncı, Ülkü Aypar, ve Esin Asan. “Effects of Intra Articular Tramadol on Articular Cartilage and Synovium of Rats”. Journal of Clinical and Experimental Investigations 6, sy. 4 (Ocak 2016): 337-42. https://doi.org/10.5799/ahinjs.01.2015.04.0546.
EndNote Kola M, Uzun S, Zeybek N, Sarıcaoğlu F, Akıncı S, Aypar Ü, Asan E (01 Ocak 2016) Effects of intra articular tramadol on articular cartilage and synovium of rats. Journal of Clinical and Experimental Investigations 6 4 337–342.
IEEE M. Kola, S. Uzun, N. Zeybek, F. Sarıcaoğlu, S. Akıncı, Ü. Aypar, ve E. Asan, “Effects of intra articular tramadol on articular cartilage and synovium of rats”, J Clin Exp Invest, c. 6, sy. 4, ss. 337–342, 2016, doi: 10.5799/ahinjs.01.2015.04.0546.
ISNAD Kola, Musa vd. “Effects of Intra Articular Tramadol on Articular Cartilage and Synovium of Rats”. Journal of Clinical and Experimental Investigations 6/4 (Ocak 2016), 337-342. https://doi.org/10.5799/ahinjs.01.2015.04.0546.
JAMA Kola M, Uzun S, Zeybek N, Sarıcaoğlu F, Akıncı S, Aypar Ü, Asan E. Effects of intra articular tramadol on articular cartilage and synovium of rats. J Clin Exp Invest. 2016;6:337–342.
MLA Kola, Musa vd. “Effects of Intra Articular Tramadol on Articular Cartilage and Synovium of Rats”. Journal of Clinical and Experimental Investigations, c. 6, sy. 4, 2016, ss. 337-42, doi:10.5799/ahinjs.01.2015.04.0546.
Vancouver Kola M, Uzun S, Zeybek N, Sarıcaoğlu F, Akıncı S, Aypar Ü, Asan E. Effects of intra articular tramadol on articular cartilage and synovium of rats. J Clin Exp Invest. 2016;6(4):337-42.