A COMMON GENETIC ETIOLOGY FOR IMPULSIVITY AND OVEREATING

Abstract

In its most basic form impulsivity, a heritable trait, is defined as a tendency to act without control and has been implicated in the onset, symptomatic expression, and maintenance of overeating. Specifically, high impulsivity and its related constructs such as poor inhibitory control and high sensitivity for reward and environmental cues have been shown to perpetuate binging and overeating. Thus, several studies have been conducted to investigate the possible common genetic etiologies for high impulsivity and overeating. The purpose of this review is to summarize the genetic findings indicating an association between impulsivity and overeating.

Keywords

• Overeating,Impulsivity,Polymorphism,Genetic,Impulse control,Binge eating

References

1. Aarts, E., Roelofs, A., Franke, B., Rijpkema, M., Fernández, G., Helmich, R.C., Cools, R. (2010). Striatal dopamine mediates the interface between motivational and cognitive control in humans: evidence from genetic imaging. Neuropsychopharmacology, 35(9), 1943-1951.
2. Asghari, V., Sanyal, S., Buchwaldt, S., Paterson, A., Jovanovic, V., Van Tol, H.H.M. (1995). Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. Journal of Neurochemistry, 65(3), 1157-1165.
3. Batterink, L., Yokum, S., Stice, E. (2010). Body mass correlates inversely with inhibitory control in response to food among adolescent girls: an fMRI study. Neuroimage, 52(4), 1696-1703.
4. Bevilacqua, L., Goldman, D. (2013). Genetics of impulsive behaviour. Philosophical Transactions of the Royal Society of London B: Biological Sciences, 368(1615), 1-12.
5. Bilder, R.M., Volavka, J., Lachman, H.M., Grace, A.A. (2004). The catechol-O methyltransferase polymorphism: relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes. Neuropsychopharmacology, 29(11), 1943-1961.
6. Blaiss, C.A., Janak, P.H. (2009). The nucleus accumbens core and shell are critical for theexpression, but not the consolidation, of Pavlovian conditioned approach. Behavioural Brain Research, 200(1), 22-32.
7. Chan, T.W.S., Bates, J.E., Lansford, J.E., Dodge, K.A., Pettit, G.S., Dick, D.M., Latendresse, S.J. (2014). Impulsivity and genetic variants in DRD2 and ANKK1 moderate longitudinal associations between sleep problems and overweight from ages 5 to 11. International Journal of Obesity, 38(3), 404-410.
8. Chen, T.J., Blum, K., Kaats, G., Braverman, E., Pullin, D., Downs, B.W., Martinez-Pons, M., Blum, S.H., Mengucci, J., Bagchi, D., Bagchi M., Robarge, A., Meshkin, B., Arcuri, V., Varshavskiy, M., Notaro, A., Comings, D.E., White, L. (2007). Reviewing the role of putative candidate genes in “neurobesigenics,” a clinical subtype of reward deficiency syndrome (RDS). Gene Therapy and Molecular Biology, 11, 61-74.

9. Chuang, Y.F., Tanaka, T., Beason-Held, L.L., An, Y., Terracciano, A., Sutin, A.R., Kraut, M., Singleton, A.B., Resnick, S.M., Thambisetty, M. (2015). FTO genotype and aging: pleiotropic longitudinal effects on adiposity, brain function, impulsivity and diet. Molecular Psychiatry, 20(1), 140-147.
10. Davis, C.A., Levitan, R.D., Reid, C., Carter, J.C., Kaplan, A.S., Patte, K.A., King, N., Curtis, C., Kennedy, J.L. (2009). Dopamine for “wanting” and opioids for “liking”: a comparison of obese adults with and without binge eating. Obesity, 17(6), 1220-1225.
11. Davis, C., Levitan, R.D., Yilmaz, Z., Kaplan, A.S., Carter, J.C., Kennedy, J.L. (2012). Binge eating disorder and the dopamine D2 receptor: genotypes and sub-phenotypes. Progress in Neuro- Psychopharmacology and Biological Psychiatry, 38(2), 328-335.
12. Depue, B.E., Olson-Madden, J.H., Smolker, H.R., Rajamani, M., Brenner, L.A., Banich, M.T. (2014). Reduced amygdala volume is associated with deficits in inhibitory control: a voxel-and surface-based morphometric analysis of comorbid PTSD/mild TBI. BioMed Research International, BioMed Research International, 2014, 1-11.
13. Dong, D., Wang, Y., Jackson, T., Chen, S., Wang, Y., Zhou, F., Chen, H. (2016). Impulse controland restrained eating among young women: Evidence for compensatory cortical activation duringa chocolate-specific delayed discounting task. Appetite, 105, 477-486.
14. Epstein, L.H., Temple, J.L., Neaderhiser, B.J., Salis, R.J., Erbe, R.W., Leddy, J.J. (2007). Food reinforcement, the dopamine D2 receptor genotype, and energy intake in obese and nonobese humans. Behavioral Neuroscience, 121(5), 877-868.
15. Erritzoe, D., Frokjaer, V.G., Haugbol, S., Marner, L., Svarer, C., Holst, K., Baaré, W.F., Rasmussen, P.M., Madsen, J., Paulson, O.B., Knudsen, G.M. (2009). Brain serotonin 2A receptor binding: relations to body mass index, tobacco and alcohol use. NeuroImage, 46(1), 23-30.
16. Felsted, J.A., Ren, X., Chouinard-Decorte, F., Small, D.M. (2010). Genetically determined differences in brain response to a primary food reward. Journal of Neuroscience, 30(7), 2428-2432.
17. Fields, S.A., Sabet, M., Reynolds, B. (2013). Dimensions of impulsive behavior in obese, overweight, and healthy-weight adolescents. Appetite, 70, 60-66.
18. Geliebter, A., Ladell, T., Logan, M., Schweider, T., Sharafi, M., Hirsch, J. (2006). Responsivity to food stimuli in obese and lean binge eaters using functional MRI. Appetite, 46(1), 31-35.
19. Heinzel, S., Dresler, T., Baehne, C.G., Heine, M., Boreatti-Hummer, A., Jacob, C.P., Renner, T.J., Reif, A., Lesch, K.P., Fallgatter, A.J., Ehlis, A.C. (2012). COMT× DRD4 epistasis impacts prefrontal cortex function underlying response control. Cerebral Cortex, 23(6), 1453-1462.
20. Hersrud, S.L., Stoltenberg, S.F. (2009). Epistatic interaction between COMT and DAT1 genes on eating behavior: a pilot study. Eating Behaviors, 10(2), 131-133.
21. Hess, M.E., Hess, S., Meyer, K.D., Verhagen, L.A., Koch, L., Bronneke, H.S., Dietrich, M.O., Jordan, S.D., Saletore, Y., Elemento, O., Belgardt, B.F., Franz, T., Horvath, T.L., Rüther, U., Jaffrey, S.R., Kloppenburg, P., Brüning, J.C. (2013). The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. Nature Neuroscience, 16(8), 1042-1048.
22. Ho, A.J., Stein, J.L., Hua, X., Lee, S., Hibar, D.P., Leow, A.D., Dinov, I.D., Toga, A.W., Saykin, A.J., Shen, L., Foroud, T., Pankratz, N., Huentelman, M.J., Craig, D.W., Gerber, J.D., Allen, A.N., Corneveaux, J.J., Stephan, D.A., DeCarli, C.S., DeChairo, B.M., Potkin, S.G., Jack, C.R. Jr., Weiner, M.W., Raji, C.A., Lopez, O.L., Becker, J.T., Carmichael, O.T., Thompson, P.M. (2010). A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly. Proceedings of the National Academy of Sciences, 107(18), 8404-8409.
23. Jansen, A., Vanreyten, A., van Balveren, T., Roefs, A., Nederkoorn, C., Havermans, R. (2008). Negative affect and cue-induced overeating in non-eating disordered obesity. Appetite, 51(3), 556-562.
24. Jonsson, E.G., Nothen, M.M., Grunhage, F., Farde, L., Nakashima, Y., Propping, P., Sedvall, G.C. (1999). Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers. Molecular Psychiatry, 4(3), 290-296. Kakoschke, N., Kemps, E. Tiggemann, M. (2015). Combined effects of cognitive bias for food cues and poor inhibitory control on unhealthy food intake. Appetite, 87, 358-364.
25. Kuikka, J.T., Tammela, L., Karhunen, L., Rissanen, A., Bergstrom, K.A., Naukkarinen, H., Vanninen, E., Karhu, J., Lappalainen, R., Repo-Tiihonen, E., Tiihonen, J., Uusitupa, M. (2001). Reduced serotonin transporter binding in binge eating women. Psychopharmacology, 155(3), 310-314.
26. Lancaster, T.M., Linden, D.E., Heerey, E.A. (2012). COMT val158met predicts reward responsiveness in humans. Genes, Brain and Behavior, 11(8), 986-992.
27. Leehr, E.J., Schag, K., Bruckmann, C., Plewnia, C., Zipfel, S., Nieratschker, V., Giel, K.E. (2016). A putative association of COMT Val (108/158) Met with impulsivity in binge eating disorder. European Eating Disorders Review, 24(2), 169-173.
28. Meule, A., Blechert, J. (2017). Indirect effects of trait impulsivity on body mass. Eating Behaviors, 26, 66-69.
29. Meule, A., de Zwaan, M., Muller, A. (2017). Attentional and motor impulsivity interactively predict ‘food addiction’ in obese individuals. Comprehensive Psychiatry, 72, 83-87.
30. Nederkoorn, C., Jansen, E., Mulkens, S., Jansen, A. (2007). Impulsivity predicts treatment outcome in obese children. Behaviour Research and Therapy, 45(5), 1071-1075. Nederkoorn, C., Coelho, J.S., Guerrieri, R., Houben, K., Jansen, A. (2012). Specificity of the failure to inhibit responses in overweight children. Appetite, 59(2), 409-413.
31. Neville, M.J., Johnstone, E.C., Walton, R.T. (2004). Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23. 1. Human Mutation, 23(6), 540-545. Pietrzykowski, A.Z., Spijker, S. (2014). Impulsivity and comorbid traits: a multi-step approach for finding putative responsible microRNAs in the amygdala. Frontiers in Neuroscience, 8, 389.
32. Rapuano, K.M., Zieselman, A.L., Kelley, W.M., Sargent, J.D., Heatherton, T.F., Gilbert- Diamond, D. (2017). Genetic risk for obesity predicts nucleus accumbens size and responsivity to real-world food cues. Proceedings of the National Academy of Sciences, 114(1), 160-165.
33. Schag, K., Schonleber, J., Teufel, M., Zipfel, S., Giel, K.E. (2013). Food-related impulsivity in obesity and Binge Eating Disorder–a systematic review. Obesity Reviews, 14(6), 477-495.
34. Schmitz, F., Naumann, E., Biehl, S., Svaldi, J. (2015). Gating of attention towards food stimuli in binge eating disorder. Appetite, 95, 368-374.
35. Selleck, R.A., Lake, C., Estrada, V., Riederer, J., Andrzejewski, M., Sadeghian, K., Baldo, B.A. (2015). Endogenous opioid signaling in the medial prefrontal cortex is required for the expression of hunger-induced impulsive action. Neuropsychopharmacology, 40(10), 2464-2474.
36. Steiger, H., Thaler, L., Gauvin, L., Joober, R., Labbe, A., Israel, M., Kucer, A. (2016). Epistatic interactions involving DRD2, DRD4, and COMT polymorphisms and risk of substance abuse in women with binge-purge eating disturbances. Journal of Psychiatric Research, 77, 8-14.
37. Stice, E., Spoor, S., Bohon, C., Veldhuizen, M.G., Small, D.M. (2008a). Relation of reward from food intake and anticipated food intake to obesity: a functional magnetic resonance imaging study. Journal of Abnormal Psychology, 117(4), 924.
38. Stice, E., Spoor, S., Bohon, C., Small, D.M. (2008b). Relation between obesity and blunted striatal response to food is moderated by TaqIA A1 allele. Science, 322(5900), 449-452.
39. Stoeckel, L.E., Weller, R.E., Cook, E.W., Twieg, D.B., Knowlton, R.C., Cox, J.E. (2008). Widespread reward-system activation in obese women in response to pictures of high-calorie foods. NeuroImage, 41(2), 636-647.
40. Stoltenberg, S.F., Christ, C.C., Highland, K.B. (2012). Serotonin system gene polymorphisms are associated with impulsivity in a context dependent manner. Progress in Neuro- Psychopharmacology and Biological Psychiatry, 39(1), 182-191.
41. Tammela, L.I., Rissanen, A., Kuikka, J.T., Karhunen, L.J., Bergstrom, K.A., Repo-Tiihonen, E., Naukkarinen, H., Vanninen, E., Tiihonen, J., Uusitupa, M. (2003). Treatment improves serotonin transporter binding and reduces binge eating. Psychopharmacology, 170(1), 89-93.
42. Uher, R., Treasure, J. (2005). Brain lesions and eating disorders. Journal of Neurology, Neurosurgery & Psychiatry, 76(6), 852-857.
43. Volkow, N.D., Baler, R.D. (2015). NOW vs LATER brain circuits: implications for obesity and addiction. Trends in Neurosciences, 38(6), 345-352.
44. Wallace, D.L., Aarts, E., Uquillas, F.D.O., Dang, L.C., Greer, S.M., Jagust, W.J., D'Esposito, M. (2015). Genotype status of the dopamine-related catechol-O-methyltransferase (COMT) gene corresponds with desirability of “unhealthy” foods. Appetite, 92, 74-80.
45. Wang, G.J., Volkow, N.D., Logan, J., Pappas, N.R., Wong, C.T., Zhu, W., Netusll, N., Fowler, J.S. (2001). Brain Dopamine and Obesity. The Lancet, 357(9253), 354-357.
46. Weygandt, M., Mai, K., Dommes, E., Ritter, K., Leupelt, V., Spranger, J., Haynes, J.D. (2015). Impulse control in the dorsolateral prefrontal cortex counteracts post-diet weight regain in obesity. NeuroImage, 109, 318-327.
47. Wonderlich, S.A., Crosby, R.D., Joiner, T., Peterson, C.B., Bardone-Cone, A., Klein, M., Crow, S., Mitchell, J.E., Le Grange, D., Steiger, H., Kolden, G., Johnson, F., Vrshek, S. (2005). Personality subtyping and bulimia nervosa: psychopathological and genetic correlates. Psychological Medicine, 35(05), 649-657.
48. Yacubian, J., Sommer, T., Schroeder, K., Glascher, J., Kalisch, R., Leuenberger, B., Braus, D.T., Büchel, C. (2007). Gene–gene interaction associated with neural reward sensitivity. Proceedings of the National Academy of Sciences, 104(19), 8125-8130.
49. Zhao, J., Goldberg, J., Vaccarino, V. (2013). Promoter methylation of serotonin transporter gene is associated with obesity measures: a monozygotic twin study. International Journal of Obesity, 37(1), 140-145.