Mitofaji ve Obezite

Yıl 2022, Cilt: 6 Sayı: 2, 55 - 60, 28.09.2022

Şermin Durak , Saadet Büşra Aksoyer Sezgin , Faruk Çelik , Aydın Çevik , İlhan Yaylım , Ümit Zeybek

https://doi.org/10.29228/JOHSE.22

Öz

Obezitede aşırı beslenme ve yüksek yağlı diyetler, enerji homeostazında ve aerobik solunumda bozulmalara, ROS üretiminde artışa ve inflamasyon durumu gibi bir çok metabolik değişikliğe sebep olmaktadır. Obezite aracılı meydana gelen oksidatif stres ve düşük seviyeli kronik inflamasyon, Tip 2 Diabetes Mellitus gibi metabolik sendromla ilişkili hastalıkların patofizyolojisinde rol oynayan mitokondriyal homeostazın bozulmasına neden olabilir. Mitokondri organeli enerji ve kalsiyum homeostazında, hücre metabolizmasında hatta kanser metabolizmasında etkin rol oynamaktadır. Mitokondriyal kurtarma operasyonu olarak bilinen mitofaji, obez hastalarda mitokondriyal hemostazın korunmasına ve hücresel anormalliklerin iyileşmesine büyük katkı sağlayan kritik bir faktör olarak düşünülmektedir. Bu derlemenin amacı, obezite patofizyolojisinde mitokondriyal disfonksiyon gelişiminin ve mitofajinin koruyucu etkisinin güncel ve kapsamlı bir özetini sunmaktır.

Anahtar Kelimeler

Mitophagy, Obesity, Mitochondriyal dysfunction, Adipose Tissue

Kaynakça

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