A case with chronic hepatitis B and anterior uveitis - Is there any connection?

Abstract

Acute anterior uveitis is an intraocular inflammation and the responsible factors of its pathogenesis are mostly unknown. Some viruses such as HSV, CMV and VZV may be implicated in the etiology. Noninfectious uveitis is thought to be autoimmune. Chronic hepatitis B virus (HBV) infection may cause multiple complications, which are thought to be immune system mediated. Recently, some studies suggested that HBV could be one of the triggers for uveitis. In this paper we present an anterior uveitis case developed in a woman who has had a chronic HBV infection. The reason for uveitis was unknown and we considered HBV as possible etiologic agent.

Keywords

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A case with chronic hepatitis B and anterior uveitis - Is there any connection?

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Kaynakça

1. Walsh K, Alexander GJ. Update on chronic viral hepatitis. Postgrad Med J 2001;77:498-505.
2. Singh DP, Kikuchi T, Singh VK, Shinohara T. A single amino acid substitution in core residues of S-antigen prevents ex- perimental autoimmune uveitis. J Immunol 1994;152: 4699- 4705.
3. Maya R, Gershwin ME, Shoenfeld Y. Hepatitis B virus (HBV) and autoimmune disease. Clin Rev Allergy Immunol 2008;34:85-102.
4. Grob PJ, Martenet AC, Witmer R. Nonspecific immune param- eters and hepatitis B antigens in patients with uveitis. Mod Probl Ophthalmol 1976; 16: 254-258.
5. Murray PI, Prasad J, Rahi AH. Status of hepatitis B virus in the aetiology of uveitis in Great Britain. Br J Ophthalmol 1983;67:685-687.
6. Murray PI, Waite J, Rahi AH, Tedder RS. Acute anterior uveitis and hepatitis B virus infection. Br J Ophthalmol 1984;68:595- 597.
7. Fraunfelder FW, Suhler EB, Fraunfelder FT. Hepatitis B vac- cine and uveitis: an emerging hypothesis suggested by re- view of 32 case reports. Cutan Ocul Toxicol 2010;29:26-29.
8. Lim LL, Scarborough JD, Thorne JE, et al. Uveitis in pa- tients with autoimmune hepatitis. Am J Ophthalmol 2009; 147:332-8 e1.

9. Damien Sène, Valérie Touitou, Bahram Bodaghi, et al. Intraoc- ular complications of IFN-α and ribavirin therapy in patients with chronic viral hepatitis C. World J Gastroenterol 2007; 13: 3137-3140.
10. Michael R. Narkewicz, Philip Rosenthal, Kathleen B Schwarz, et al. Ophthalmologic Complications In Children With Chronic Hepatitis C Treated With Pegylated Interferon. Pediatr Gas- troenterol Nutr 2010 ; 51: 183–186.
11. Sobaci G, Erdem U, Durukan AH, et al. Safety and effec- tiveness of Interferon Alpha-2a in treatment of patients with Behcet’s Uveitis refractory to conventional treatments. Oph- thalmology 2010; 117:1430-1435.