Prognostic value of mean platelet volume and neutrophil to lymphocyte ratio in patients with Crimean-Congo Hemorrhagic Fever

Abstract

Objective: Crimean-Congo hemorrhagic fever (CCHF) virus, a Nairovirus within the family Bunyaviridae, causes severe disease in humans. Pancytopenia, organ failures and disseminated intravascular coagulation may occur as a result of CCHF infection. The aim of this study was to determine whether there is a change in the mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), and whether these might be predictors for the duration of hospitalization.

Methods: A total of 50 CCHF patients (27 M and 23 F) and a similar age group of 47 healthy individuals (27 M and 20 F) were included in the study. Hematologic and biochemical tests inclusive of C-reactive protein were conducted on patients and controls. To determine the independent predictors of the duration of hospitalization, a multivariate logistic regression analysis was performed.

Results: The MPV was higher in patients than that of the controls [8.4 (min/max 6.4-9.4) fL vs. 7.0 (min/max 6.0-8.7) fL, p<0.001]. The NLR and PLR were similar in both groups. The predictors of the length of hospitalization included decreased white blood (WBC) cell and platelet counts (p<0.001 and p=0.002, respectively), together with elevated pro­thrombin time (PT) (p=0.013) creatinine (p=0.033) and glucose levels (p=0.044).

Conclusion: The MPV was higher in patients but NLR and PLR were similar in both groups. The MPV, NLR and PLR did not serve as predictors of hospitalization length. However, elevation of PT, creatinine, glucose, along with decreased WBC and platelets counts were found to be predictors of hospitalization period. J Microbiol Infect Dis 2015;5(2): 51-56

Ayşe Ertürk, Erkan Cüre, Emine Parlak, Medine Cumhur Cüre, Süleyman Yüce, Zulal Özkurt

Prognostic value of mean platelet volume and neutrophil to lymphocyte ratio in patients with Crimean-Congo Hemorrhagic Fever Ayşe Ertürk, Erkan Cüre, Emine Parlak, Medine Cumhur Cüre, Süleyman Yüce, Zulal Özkurt  Recep Tayyip Erdogan University, School of Medicine, Department of Infectious Disease, Rize, Turkey. J Microbiol Infect Dis 2015; 5(2): 51-56 doi: 10.5799/ahinjs.02.2015.02.0176

Key words: Crimean-Congo hemorrhagic fever; mean platelet volume; neutrophil-to-lymphocyte ratio; platelet-tolymphocyte ratio; hospitalization period.

Keywords

• Crimean-Congo hemorrhagic fever; mean platelet volume; neutrophil-to-lymphocyte ratio; platelet-tolymphocyte ratio; hospitalization period

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Öz

Amaç: Kırım-Kongo Kanamalı Ateşi (KKHA) virüsü, Bunyaviridae ailesine üye Nairovirus olup insanlarda ciddi hastalığa neden olur. KKKA enfeksiyonunda pansitopeni, organ yetersizliği ve yaygın damar-içi pıhtılaşma ortaya çıkabilir. Bu çalışmanın amacı, ortalama trombosit hacmi (MPV), nötrofil-lenfosit oranı (NLR) ve trombosit-lenfosit oranı (PLR)’nda bir değişiklik olup olmadığını ve bu parametrelerin hastanede kalış süresi için prediktör olup olamayacağını belirlemektir.Yöntem: Toplam 50 KKHA hastalığı bulunan (27 M ve 23 F) ve benzer yaş grubunda toplam 47 (27 M ve 20 F) sağlıklı birey çalışmaya alındı. Hematolojik ve biyokimyasal testleri ile C-reaktif protein (CRP), hasta ve kontrollerde çalışıldı. Hastanede kalış süresi üzerinde bağımsız prediktörleri belirlemek amacıyla çok değişkenli lojistik regresyon analizi yapıldı.Bulgular: MPV, hastalarda kontrollerden daha yüksek [8.4 (min / maks 6,4-9,4) fL vs 7.0 (min/maks 6,0-8,7) fL, p <0.001] idi. NLR ve PLR her iki grupta benzerdi. Hastanede kalış süresi prediktörleri: düşük beyaz kan hücreleri (WBC) ve trombosit sayısı (p <0.001 ve p=0.002 sırasıyla), bunlar yanı sıra uzamış protrombin zamanı (PT) (p=0.013), yüksek kreatinin (p=0.033) ve glukoz (p=0.044) düzeyleri olarak saptandı.Sonuç: MPV hasta grubunda daha yüksek olup NLR ve PLR oranları kontrol grubu ile benzerdi. MPV, NLR ve PLR hastanede kalış uzunluğu belirleyicisi olarak tespit edilmedi. Ancak, azalmış lökosit ve trombosit sayımı ile birlikte uzamış PT, artmış kreatinin ve glukoz düzeyleri, hospitalizasyon süresini predikte ettiği bulundu

Anahtar Kelimeler

• Kırım-Kongo Kanamalı Ateşi; ortalama trombosit hacmi; nötrofil/lenfosit oranı; trombosit/lenfosit oranı; hastanede yatış süresi

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