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Yıl 2020, , 110 - 120, 15.09.2020

Uzair Ahmed Usman Ali Ashfaq Saba Khaliq Muhammad Qasim Shah Jahan Muhammad Shareef Masoud

https://doi.org/10.5799/jmid.790198
Cited By: 1

Öz

Kaynakça

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Current trends and possible therapeutic options against COVID-19

Yıl 2020, , 110 - 120, 15.09.2020

Uzair Ahmed Usman Ali Ashfaq Saba Khaliq Muhammad Qasim Shah Jahan Muhammad Shareef Masoud

https://doi.org/10.5799/jmid.790198
Cited By: 1

Öz

COVID-19 is a highly contagious disease, caused by SARS-CoV-2, which can be transmitted from person to person. SARS-CoV-2 has thought to be originated in bats and transmitted to humans. SARS-CoV-2 has ssRNA genome that is about 30kb in length and it enters lung epithelial cells using spikes (S) by binding with Angiotensin‐converting enzyme 2 (ACE-2). Till date, there is no definitive treatment available for COVID-19 and currently, only symptomatic treatments are available. There is no vaccine developed to combat COVID-19 but scientists are working on developing different types of vaccines including nucleic acid vaccines, subunit vaccines and whole virus vaccines, that are effective and safe to use. Broad spectrum antivirals like ribavirin, lopinavir, ritonavir, arbidol, favipiravir, remdesivir are being test to lessen the viral load. Recently, ivermectin (anti-parasitic drug), has been administered in vitro and showed 99.8% reduction in SARS-CoV-2 in cultured cells in 48 hours. Convalescent plasma (CP) treatments are also being used in order to treat critical cases, nevertheless, no drug has been approved yet. This review focuses on the transmission, clinical features, prevention, current treatments and future possible approaches that can be used to develop therapeutic options against COVID-19. J Microbiol Infect Dis 2019; 9(3):110-120.

Anahtar Kelimeler

SARS-CoV-2 clinical features therapeutic options antivirals vaccines

Kaynakça

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  • 3.Channappanavar R, Zhao J, Perlman S. T cell-mediated immune response to respiratory coronaviruses. Immunologic Research 2014; 59: 118–128.
  • 4.Chan JFW, Lau SKP, To KKW, et al. Middle East Respiratory syndrome coronavirus: Another zoonotic betacoronavirus causing SARS-like disease. Clin Microbiol Rev 2015; 28: 465–522.
  • 5.Cheng VCC, Lau SKP, Woo PCY, et al. Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection. Clinical Microbiology Reviews 2007; 20: 660–694.
  • 6.Gralinski LE, Baric RS. Molecular pathology of emerging coronavirus infections. J Pathol 2015; 235: 185–195.
  • 7.Drosten C, Günther S, Preiser W, et al. Identification of a Novel Coronavirus in Patients with Severe Acute Respiratory Syndrome. N Engl J Med 2003; 348: 1967–1976.
  • 8.Gretebeck LM, Subbarao K. Animal models for SARS and MERS coronaviruses. Current Opinion in Virology 2015; 13: 123–129.
  • 9.Liu J, Zheng X, Tong Q, et al. Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS‐CoV, MERS‐CoV, and 2019‐nCoV. J Med Virol 2020; 92: 491–494.
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  • 15. Zhou P, Yang X Lou, Wang XG, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020; 579: 270–273.
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  • 23. Kuba K, Imai Y, Rao S, et al. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat Med 2005; 11: 875–879.
  • 24. Oudit GY, Kassiri Z, Jiang C, et al. SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS. Eur J Clin Invest 2009; 39: 618–625.
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  • 28. Graham Carlos W, Dela Cruz CS, Cao B, et al. Novel Wuhan (2019-NCoV) coronavirus. American Journal of Respiratory and Critical Care Medicine 2020; 201: P7–P8.
  • 29. Wu P, Hao X, Lau EHY, et al. Real-time tentative assessment of the epidemiological characteristics of novel coronavirus infections in Wuhan, China, as at 22 January 2020. Euro Surveill; 25. Epub ahead of print 1 January 2020. DOI: 10.2807/1560-7917.ES.2020.25.3.2000044.
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  • 31. Wan Y, Shang J, Graham R, et al. Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS. J Virol; 94. Epub ahead of print 29 January 2020. DOI: 10.1128/jvi.00127-20.
  • 32. Jaimes JA, Millet JK, Stout AE, et al. A Tale of Two Viruses: The Distinct Spike Glycoproteins of Feline Coronaviruses. Viruses 2020; 12: 83.
  • 33. Wu Z, McGoogan JM. Characteristics of and Important Lessons from the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72314 Cases from the Chinese Center for Disease Control and Prevention. JAMA - J Am Med Assoc. Epub ahead of print 2020. DOI: 10.1001/jama.2020.2648.
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  • 36. Chan JFW, Yuan S, Kok KH, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet 2020; 395: 514–523.
  • 37. Li Q, Guan X, Wu P, et al. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia. N Engl J Med. Epub ahead of print 29 January 2020. DOI: 10.1056/nejmoa2001316.
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  • 41. Zhang C, Huang S, Zheng F, et al. Controversial treatments: an updated understanding of the Coronavirus Disease 2019. J Med Virol 2020; n/a: 0–2.
  • 42. Chang D, Xu H, Rebaza A, et al. Protecting health-care workers from subclinical coronavirus infection. The Lancet Respiratory Medicine 2020; 8: e13.
  • 43. Walls AC, Park Y-J, Tortorici MA, et al. Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein. Cell. Epub ahead of print 6 March 2020. DOI: 10.1016/j.cell.2020.02.058.
  • 44. Tian X, Li C, Huang A, et al. Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody. Emerging Microbes and Infections 2020; 9: 382–385.
  • 45. Zheng M, Song L. Novel antibody epitopes dominate the antigenicity of spike glycoprotein in SARS-CoV-2 compared to SARS-CoV. Cell Mol Immunol 2020; 1–3.
  • 46. Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. Epub ahead of print 5 March 2020. DOI: 10.1016/j.cell.2020.02.052.
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  • 48. Wang H, Yang P, Liu K, et al. SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway. Cell Res 2008; 18: 290–301.
  • 49. Inoue Y, Tanaka N, Tanaka Y, et al. Clathrin-Dependent Entry of Severe Acute Respiratory Syndrome Coronavirus into Target Cells Expressing ACE2 with the Cytoplasmic Tail Deleted. J Virol 2007; 81: 8722–8729.
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  • 51. Wang M, Cao R, Zhang L, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Research 2020; 30: 269–271.
  • 52. Gao J, Tian Z, Yang X. Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies. Biosci Trends 2020; 14: 72–73.
  • 53. Yao X, Ye F, Zhang M, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. Epub ahead of print 2020. DOI: 10.1093/cid/ciaa237/5801998.
  • 54. Savarino A, Boelaert JR, Cassone A, et al. Effects of chloroquine on viral infections: An old drug against today’s diseases? Lancet Infectious Diseases 2003; 3: 722–727.
  • 55. Vincent MJ, Bergeron E, Benjannet S, et al. Chloroquine is a potent inhibitor of SARS coronavirus infection and spread. Virol J 2005; 2: 1–10.
  • 56. Golden EB, Cho HY, Hofman FM, et al. Quinoline-based antimalarial drugs: A novel class of autophagy inhibitors. Neurosurg Focus; 38. Epub ahead of print 2015. DOI: 10.3171/2014.12.FOCUS14748.
  • 57. Martinez MA. Compounds with therapeutic potential against novel respiratory 2019 coronavirus. Antimicrob Agents Chemother 2020; 1–18.
  • 58. Gordon CJ, Tchesnokov EP, Feng JY, et al. The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus. J Biol Chem 2020; jbc.AC120.013056.
  • 59. Li G, De Clercq E. Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nature reviews. Drug discovery 2020; 19: 149–150.
  • 60. Morse JS, Lalonde T, Xu S, et al. Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019‐nCoV. ChemBioChem 2020; 21: 730–738.
  • 61. Li Y, Zhang J, Wang N, et al. Therapeutic Drugs Targeting 2019-nCoV Main Protease by High-Throughput Screening. bioRxiv 2020; 2020.01.28.922922.
  • 62. Caly L, Druce JD, Catton MG, et al. The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro. Antiviral Res 2020; 104787.
  • 63. Nguyen TM, Zhang Y, Pandolfi PP. Virus against virus: a potential treatment for 2019-nCov (SARS-CoV-2) and other RNA viruses. Cell Research 2020; 30: 189–190.
  • 64. Russell CD, Millar JE, Baillie JK. Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury. The Lancet 2020; 395: 473–475.
  • 65. Zhou W, Liu Y, Tian D, et al. Potential benefits of precise corticosteroids therapy for severe 2019-nCoV pneumonia. Signal Transduction and Targeted Therapy 2020; 5: 1–3.
  • 66. Zhou Y, Fu B, Zheng X, et al. Aberrant pathogenic GM-CSF+ T cells and inflammatory CD14+CD16+ monocytes in severe pulmonary syndrome patients of a new coronavirus. bioRxiv 2020; 2020.02.12.945576.
  • 67. Fu Y, Cheng Y, Wu Y. Understanding SARS-CoV-2-Mediated Inflammatory Responses: From Mechanisms to Potential Therapeutic Tools. Virologica Sinica 2020; 1–6.
  • 68. Marano G, Vaglio S, Pupella S, et al. Convalescent plasma: New evidence for an old therapeutic tool? Blood Transfusion 2016; 14: 152–157.
  • 69. Chen L, Xiong J, Bao L, et al. Convalescent plasma as a potential therapy for COVID-19. Lancet Infect Dis 2020; 20: 398–400.
  • 70. Garraud O, Heshmati F, Pozzetto B, et al. Plasma therapy against infectious pathogens, as of yesterday, today and tomorrow. Transfus Clin Biol 2016; 23: 39–44.
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  • 74. Pang J, Wang MX, Ang IYH, et al. Potential Rapid Diagnostics, Vaccine and Therapeutics for 2019 Novel Coronavirus (2019-nCoV): A Systematic Review. J Clin Med 2020; 9: 623.
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  • 80. Biopharmaceuticals C. Clover Initiates Development of Recombinant Subunit-Trimer Vaccine for Wuhan Coronavirus (2019-nCoV) | Vaccines | News Channels, https://pipelinereview.com/index.php/2020012873644/Vaccines/Clover-Initiates-Development-of-Recombinant-Subunit-Trimer-Vaccine-for-Wuhan-Coronavirus-2019-nCoV.html (2020, accessed 3 April 2020).
  • 81. Smith J. CureVac Bids to Develop First mRNA Coronavirus Vaccine Let’ s Continue the Conversation, https://www.labiotech.eu/medical/curevac-coronavirus-outbreak-cepi/ (2020, accessed 3 April 2020).
  • 82. Pharmaceuticals I. Inovio Pharmaceuticals, Inc. - Inovio Collaborating with Beijing Advaccine To Advance INO-4800 Vaccine Against New Coronavirus In China, http://ir.inovio.com/news-and-media/news/press-release-details/2020/Inovio-Collaborating-With-Beijing-Advaccine-To-Advance-INO-4800-Vaccine-Against-New-Coronavirus-In-China/default.aspx (2020, accessed 3 April 2020).
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  • 87. SINOPHARM, http://www.sinopharm.com/1156.html (2020, accessed 24 July 2020). 8. SINOVAC - Supply Vaccines to Eliminate Human Diseases, http://www.sinovac.com/ (2020, accessed 24 July 2020).
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  • 90. CanSino Biologics Inc, http://www.cansinotech.com/ (2020, accessed 24 July 2020).
Toplam 89 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Derleme
Yazarlar

Uzair Ahmed Bu kişi benim

Usman Ali Ashfaq Bu kişi benim

Saba Khaliq Bu kişi benim

Muhammad Qasim Bu kişi benim

Shah Jahan Bu kişi benim

Muhammad Shareef Masoud Bu kişi benim

Yayımlanma Tarihi 15 Eylül 2020
Yayımlandığı Sayı Yıl 2020

Kaynak Göster

APA Ahmed, U., Ashfaq, U. A., Khaliq, S., Qasim, M., vd. (2020). Current trends and possible therapeutic options against COVID-19. Journal of Microbiology and Infectious Diseases, 10(03), 110-120. https://doi.org/10.5799/jmid.790198
AMA Ahmed U, Ashfaq UA, Khaliq S, Qasim M, Jahan S, Masoud MS. Current trends and possible therapeutic options against COVID-19. J Microbil Infect Dis. Eylül 2020;10(03):110-120. doi:10.5799/jmid.790198
Chicago Ahmed, Uzair, Usman Ali Ashfaq, Saba Khaliq, Muhammad Qasim, Shah Jahan, ve Muhammad Shareef Masoud. “Current Trends and Possible Therapeutic Options Against COVID-19”. Journal of Microbiology and Infectious Diseases 10, sy. 03 (Eylül 2020): 110-20. https://doi.org/10.5799/jmid.790198.
EndNote Ahmed U, Ashfaq UA, Khaliq S, Qasim M, Jahan S, Masoud MS (01 Eylül 2020) Current trends and possible therapeutic options against COVID-19. Journal of Microbiology and Infectious Diseases 10 03 110–120.
IEEE U. Ahmed, U. A. Ashfaq, S. Khaliq, M. Qasim, S. Jahan, ve M. S. Masoud, “Current trends and possible therapeutic options against COVID-19”, J Microbil Infect Dis, c. 10, sy. 03, ss. 110–120, 2020, doi: 10.5799/jmid.790198.
ISNAD Ahmed, Uzair vd. “Current Trends and Possible Therapeutic Options Against COVID-19”. Journal of Microbiology and Infectious Diseases 10/03 (Eylül 2020), 110-120. https://doi.org/10.5799/jmid.790198.
JAMA Ahmed U, Ashfaq UA, Khaliq S, Qasim M, Jahan S, Masoud MS. Current trends and possible therapeutic options against COVID-19. J Microbil Infect Dis. 2020;10:110–120.
MLA Ahmed, Uzair vd. “Current Trends and Possible Therapeutic Options Against COVID-19”. Journal of Microbiology and Infectious Diseases, c. 10, sy. 03, 2020, ss. 110-2, doi:10.5799/jmid.790198.
Vancouver Ahmed U, Ashfaq UA, Khaliq S, Qasim M, Jahan S, Masoud MS. Current trends and possible therapeutic options against COVID-19. J Microbil Infect Dis. 2020;10(03):110-2.

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Current advancements and future prospects of COVID-19 vaccines and therapeutics: a narrative review
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https://doi.org/10.1177/25151355221097559