Covid-19 Reinfection Dynamics-Is Immunity Short Lasting? Case Series of Healthcare Workers

Öz

The rapidly spreading Covid-19 pandemic resulted in more than 4.7 million cases diagnosed and 78,727 deaths on September 14, 2020. SARS-CoV-2 was first expected to induce a monophasic disease with at least transient immunity. Here we report a case series of five cases of RT-PCR proved reinfection of Covid-19 in health care workers. On returning to work they might experience a Covid-19 “recurrence” or “reactivation” with increased severity of symptoms after a median symptom-free interval requiring hospitalization which raises the question is the immunity short-lasting. Further studies are required to fully understand the effect of Covid-19 on the immunity of humans in the community. J Microbiol Infect Dis 2021; 11(2):105-107.

Anahtar Kelimeler

• Covid-19
• Severe acute respiratory syndrome coronavirus 2
• Pandemic
• Recurrence
• Coronavirus infection

Kaynakça

1. 1. Kiyuka PK, Agoti CN, Munywoki PK, et al. Human coronavirus NL63 molecular epidemiology and evolutionary patterns in rural coastal Kenya. J Infect Dis. 2018; 217(11):1728-1739.
2. 2. Tang F, Quan Y, Xin ZT, et al. Lack of peripheral memory B cell responses in recovered patients with severe acute respiratory syndrome: a six-year follow-up study. J Immunol. 2011; 186(12):7264-7268.
3. 3. Ye G, Pan Z, Pan Y, et al. Clinical characteristics of severe acute respiratory syndrome coronavirus 2 reactivation. J Infect 2020 80(5):e14-e17.
4. 4. Grifoni A, Weiskopf D, Ramirez SI, et al. Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals. Cell 2020;181(7):1489-1501.e15.
5. 5. Xiao AT, Tong YX, Zhang S. Profile of RT-PCR for SARS-CoV-2: a preliminary study from 56 COVID-19 patients. Clin Infect Dis 2020; 19;71(16):2249-2251.
6. 6. Gousseff M, Penot P, Gallay L, et al. Clinical recurrences of COVID-19 symptoms after recovery: viral relapse, reinfection or inflammatory rebound? J Infect 2020; 81(5):816-846.
7. 7. Zhao J, Yuan Q, Wang H, et al. Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019. Clin Infect Dis. 2020; 71(16):2027-2034.
8. 8. Ling Y, Xu SB, Lin YX, et al. Persistence and clearance of viral RNA in 2019 novel coronavirus disease rehabilitation patients. Chin Med J (Engl) 2020; 133(9):1039-1043.