Araştırma Makalesi
BibTex RIS Kaynak Göster

Epidemiology of Hepatitis C Virus and Human Immunodeficiency Virus Co-Infection and Challenges in Their Diagnosis

Yıl 2017, Cilt: 07 Sayı: 04, 167 - 172, 01.12.2017
https://doi.org/10.5799/jmid.368504

Öz

Objective:
To screen HCV infection in HIV infected individuals and to
compare the genotype and viral load of HCV in these co infected patients versus
HIV negative individuals.



Methods:
Serum samples from 70 HIV infected patients and 70 HIV
negative individuals who enrolled in the ART center were retrospectively
analyzed for the presence of anti HCV antibodies and for HCV RNA. Genotyping
and viral load were further determined in HCV RNA positive patients.



Results:
HCV infection (either positive for anti HCV Ab, or HCV
RNA or both) was found in 8.57% HIV infected cases as compared to 2.85%
individuals in the HIV uninfected control group. HCV RNA levels were higher in
HIV infected subjects versus HIV negative individuals. Among the HIV positive
cases, out of the three HCV RNA positive cases, two individuals had genotype 3
and one individual was found to have mixed genotype (1+3) as compared to
genotype 1 and genotype 3 in HIV negative healthy controls.



Conclusion: In our study, HCV
infection was found more frequently in HIV infected individuals as compared to
HIV non infected individuals. Therefore a routine screening test followed by a
confirmatory test should be made mandatory in co infected patients. 

Kaynakça

  • REFERENCES 1. Jain M, Chakravarti A, Verma V, Bhalla P. Seroprevalence of hepatitis viruses in patients infected with the human immunodeficiency virus. J Pathol Microbiol 2009; 52:17-19. 2. Brau N. Treatment of chronic hepatitis C in human immunodeficiency virus/hepatitis C virus-coinfected patients in the era of pegylated interferon and ribavirin. Semin Liver Dis 2005; 25:33-51. 3. Wright TL, Hollander H, Pu X, et al. Hepatitis C in HIV-infected patients with and without AIDS: prevalence and relationship to patient survival. Hepatology 1994; 20:1152-1155. 4. Gerlach JT, Diepolder HM, Jung MC, et al. Recurrence of hepatitis C virus after loss of virus-specific CD4 (+) T-cell response in acute hepatitis C. Gastroenterology 1999; 117:933-941. 5. Antiretroviral therapy for HIV infection in adults and adolescents: Recommendation for a public health approach. World Health Organization 2010 Revision cited 2010 January. 6. Mellor J, Holmes EC, Jarvis LM, Yap PL, Simmonds P. Investigation of the pattern of hepatitis C virus sequence diversity in different geographical regions: implications for virus classification. The international HCV Collaborative Study group. J Gen Virol 1995; 76: 2493-2507. 7. Chinchai T, Labout J, Noppornpanth S, et al. Comparative study of different methods to genotype hepatitis C virus type 6 variants. J Virol Methods 2003; 109:195-201. 8. Yang JH, Lai JP, Douglas SD, Metzger D, Zhu XH, Ho WZ. Real time RT- PCR for quantitation of hepatitis C virus RNA. J Virol Method 2002; 102:119-128. 9. HIV Sentinel Surveillance and HIV estimation in India 2007: A Technical Brief. [Online]. 2008 [cited 2009 Apr 22]; Available from: URL: http://naco.gov.in/sites/default/files/HIV%20Sentinel%20Surveillance%20and%20HIV%20Estimation%202007_A%20Technical%20Brief.pdf 10. Gupta S, Singh S. Hepatitis B and C virus co-infections in human immunodeficiency virus positive north Indian patients. World J Gastroenterol 2006; 12:6879-6883. 11. George SL, Gebhardt J, Klinzman D, et al. Hepatitis C virus viremia in HIV infected individuals with negative HCV antibody tests. J Acquir Immun Defic Syndr 2002; 31:154-162. 12. Saha ML, Chakrabarty S, Panda S, et al. Prevalence of HIV and HBV infection amongst HIV seropositive intravenous drug users and heir non-injecting wives in Manipur, India. Indian J Med Res 2000; 111:37-39. 13. Saravanan S, Velu V, Kumarasamy N, et al. Coinfection of hepatitis B and hepatitis C virus in HIV infected patients in South India. World J Gastroenterol 2007; 13; 5015-5020. 14. Matthews-Greer JM, Caldito GC, Adley SD, et al. Comparision of hepatitis C viral loads in patients with or without Human Immunodeficiency Virus. Clin Diagn Lab Immun 2001; 8: 690-694. 15. Ponamgi S, Rahamathulla S, Kumar YN, et al. Prevalence of hepatitis C virus (HCV) coinfection in HIV infected individuals in South India and characterization of HCV genotypes. Indian J Med Microbiol 2009; 27:12-16. 16. Karchava M, Sharvadze L, Gatserelia L, Badridze N, Tsertsvadze T. Prevaling HCV genotypes and subtypes among HIV infected patients in Georgia. Georgian Med News 2009; 177:51-55. 17. Pukhrambam PD, Singh NB, Singh LH, Devi KhS. Pattern of hepatitis C virus genotypes in HIV infected patients in RIMS, Hospital, Imphal, Manipur. J Commun Dis 2007; 39:21-24. 18. Chakravarti A, Dogra G, Verma V, Srivastava AP. Distribution patterns of HCV genotypes and its association with viral load. Indian J Med Research 2011; 133:326-331. 19. Soriano V, Mocroft A, Rockstorh J, et al. spontaneous viral clearance, viral load and genotype distribution of hepatitis C virus (HCV) in HIV-infected patients with anti-HCV antibodies in Europe. JID 2008; 198:1337-1344. 20. Reuter S, Oette M, Wilhhelm FC, et al. Prevalence and characteristics of hepatitis B and C virus infections in treatment -naïve HIV-infected patients. Med Microbiol Immunol 2011; 200:39-49.
Yıl 2017, Cilt: 07 Sayı: 04, 167 - 172, 01.12.2017
https://doi.org/10.5799/jmid.368504

Öz

Kaynakça

  • REFERENCES 1. Jain M, Chakravarti A, Verma V, Bhalla P. Seroprevalence of hepatitis viruses in patients infected with the human immunodeficiency virus. J Pathol Microbiol 2009; 52:17-19. 2. Brau N. Treatment of chronic hepatitis C in human immunodeficiency virus/hepatitis C virus-coinfected patients in the era of pegylated interferon and ribavirin. Semin Liver Dis 2005; 25:33-51. 3. Wright TL, Hollander H, Pu X, et al. Hepatitis C in HIV-infected patients with and without AIDS: prevalence and relationship to patient survival. Hepatology 1994; 20:1152-1155. 4. Gerlach JT, Diepolder HM, Jung MC, et al. Recurrence of hepatitis C virus after loss of virus-specific CD4 (+) T-cell response in acute hepatitis C. Gastroenterology 1999; 117:933-941. 5. Antiretroviral therapy for HIV infection in adults and adolescents: Recommendation for a public health approach. World Health Organization 2010 Revision cited 2010 January. 6. Mellor J, Holmes EC, Jarvis LM, Yap PL, Simmonds P. Investigation of the pattern of hepatitis C virus sequence diversity in different geographical regions: implications for virus classification. The international HCV Collaborative Study group. J Gen Virol 1995; 76: 2493-2507. 7. Chinchai T, Labout J, Noppornpanth S, et al. Comparative study of different methods to genotype hepatitis C virus type 6 variants. J Virol Methods 2003; 109:195-201. 8. Yang JH, Lai JP, Douglas SD, Metzger D, Zhu XH, Ho WZ. Real time RT- PCR for quantitation of hepatitis C virus RNA. J Virol Method 2002; 102:119-128. 9. HIV Sentinel Surveillance and HIV estimation in India 2007: A Technical Brief. [Online]. 2008 [cited 2009 Apr 22]; Available from: URL: http://naco.gov.in/sites/default/files/HIV%20Sentinel%20Surveillance%20and%20HIV%20Estimation%202007_A%20Technical%20Brief.pdf 10. Gupta S, Singh S. Hepatitis B and C virus co-infections in human immunodeficiency virus positive north Indian patients. World J Gastroenterol 2006; 12:6879-6883. 11. George SL, Gebhardt J, Klinzman D, et al. Hepatitis C virus viremia in HIV infected individuals with negative HCV antibody tests. J Acquir Immun Defic Syndr 2002; 31:154-162. 12. Saha ML, Chakrabarty S, Panda S, et al. Prevalence of HIV and HBV infection amongst HIV seropositive intravenous drug users and heir non-injecting wives in Manipur, India. Indian J Med Res 2000; 111:37-39. 13. Saravanan S, Velu V, Kumarasamy N, et al. Coinfection of hepatitis B and hepatitis C virus in HIV infected patients in South India. World J Gastroenterol 2007; 13; 5015-5020. 14. Matthews-Greer JM, Caldito GC, Adley SD, et al. Comparision of hepatitis C viral loads in patients with or without Human Immunodeficiency Virus. Clin Diagn Lab Immun 2001; 8: 690-694. 15. Ponamgi S, Rahamathulla S, Kumar YN, et al. Prevalence of hepatitis C virus (HCV) coinfection in HIV infected individuals in South India and characterization of HCV genotypes. Indian J Med Microbiol 2009; 27:12-16. 16. Karchava M, Sharvadze L, Gatserelia L, Badridze N, Tsertsvadze T. Prevaling HCV genotypes and subtypes among HIV infected patients in Georgia. Georgian Med News 2009; 177:51-55. 17. Pukhrambam PD, Singh NB, Singh LH, Devi KhS. Pattern of hepatitis C virus genotypes in HIV infected patients in RIMS, Hospital, Imphal, Manipur. J Commun Dis 2007; 39:21-24. 18. Chakravarti A, Dogra G, Verma V, Srivastava AP. Distribution patterns of HCV genotypes and its association with viral load. Indian J Med Research 2011; 133:326-331. 19. Soriano V, Mocroft A, Rockstorh J, et al. spontaneous viral clearance, viral load and genotype distribution of hepatitis C virus (HCV) in HIV-infected patients with anti-HCV antibodies in Europe. JID 2008; 198:1337-1344. 20. Reuter S, Oette M, Wilhhelm FC, et al. Prevalence and characteristics of hepatitis B and C virus infections in treatment -naïve HIV-infected patients. Med Microbiol Immunol 2011; 200:39-49.
Toplam 1 adet kaynakça vardır.

Ayrıntılar

Konular Sağlık Kurumları Yönetimi
Bölüm Research Article
Yazarlar

Parul Punia Bu kişi benim

Anita Chakravarti Bu kişi benim

Anjar Ashraf Bu kişi benim

Yayımlanma Tarihi 1 Aralık 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 07 Sayı: 04

Kaynak Göster

APA Punia, P., Chakravarti, A., & Ashraf, A. (2017). Epidemiology of Hepatitis C Virus and Human Immunodeficiency Virus Co-Infection and Challenges in Their Diagnosis. Journal of Microbiology and Infectious Diseases, 07(04), 167-172. https://doi.org/10.5799/jmid.368504
AMA Punia P, Chakravarti A, Ashraf A. Epidemiology of Hepatitis C Virus and Human Immunodeficiency Virus Co-Infection and Challenges in Their Diagnosis. J Microbil Infect Dis. Aralık 2017;07(04):167-172. doi:10.5799/jmid.368504
Chicago Punia, Parul, Anita Chakravarti, ve Anjar Ashraf. “Epidemiology of Hepatitis C Virus and Human Immunodeficiency Virus Co-Infection and Challenges in Their Diagnosis”. Journal of Microbiology and Infectious Diseases 07, sy. 04 (Aralık 2017): 167-72. https://doi.org/10.5799/jmid.368504.
EndNote Punia P, Chakravarti A, Ashraf A (01 Aralık 2017) Epidemiology of Hepatitis C Virus and Human Immunodeficiency Virus Co-Infection and Challenges in Their Diagnosis. Journal of Microbiology and Infectious Diseases 07 04 167–172.
IEEE P. Punia, A. Chakravarti, ve A. Ashraf, “Epidemiology of Hepatitis C Virus and Human Immunodeficiency Virus Co-Infection and Challenges in Their Diagnosis”, J Microbil Infect Dis, c. 07, sy. 04, ss. 167–172, 2017, doi: 10.5799/jmid.368504.
ISNAD Punia, Parul vd. “Epidemiology of Hepatitis C Virus and Human Immunodeficiency Virus Co-Infection and Challenges in Their Diagnosis”. Journal of Microbiology and Infectious Diseases 07/04 (Aralık 2017), 167-172. https://doi.org/10.5799/jmid.368504.
JAMA Punia P, Chakravarti A, Ashraf A. Epidemiology of Hepatitis C Virus and Human Immunodeficiency Virus Co-Infection and Challenges in Their Diagnosis. J Microbil Infect Dis. 2017;07:167–172.
MLA Punia, Parul vd. “Epidemiology of Hepatitis C Virus and Human Immunodeficiency Virus Co-Infection and Challenges in Their Diagnosis”. Journal of Microbiology and Infectious Diseases, c. 07, sy. 04, 2017, ss. 167-72, doi:10.5799/jmid.368504.
Vancouver Punia P, Chakravarti A, Ashraf A. Epidemiology of Hepatitis C Virus and Human Immunodeficiency Virus Co-Infection and Challenges in Their Diagnosis. J Microbil Infect Dis. 2017;07(04):167-72.