Interesting Case of Leptospirosis Presenting as Jaundice and Acute Renal Failure in North East Tennessee

Yıl 2018, Cilt: 08 Sayı: 02, 80 - 82, 20.06.2018

İmran Khan Muhammad Khalid Jonathan Moorman Lamis Ibrahim Dima Youssef

https://doi.org/10.5799/jmid.434637

Öz

Leptospirosis
is a worldwide zoonotic infection common in the tropics especially during the
hurricanes and floods seasons. Most common clinical presentation is rash,
fatigue, weakness, malaise, fever, headache just like viral prodromal symptoms,
but clinical presentation of jaundice liver and kidney dysfunction in severe
cases can result in multiorgan failure. Diagnosis need serology and cultures
which are usually positive early in course of the disease but require special
media to grow i.e. Fletcher’s media. Treatment is usually with Penicillin or
doxycycline. We present a case of leptospirosis presenting with jaundice along
with acute liver and renal involvement in the form of Weil’s disease which is
one of the severe form of presentation. Diagnosis was made by positive
leptospirosis serology. Patient was treated with oral doxycycline. Patient had
good response to antibiotics with resolution of symptoms on follow up
outpatient. J Microbiol Infect Dis 2018; 8(2):80-82.

Anahtar Kelimeler

Leptospirosis, renal Failure, jaundice, Weil’s disease

Kaynakça

• REFERENCES 1) Anderson DC, Holland DS, Fox MD, Patton CM, Kaufman AF. Leptospirosis: a common source outbreak due to leptospires of the grippotyphosa serogroup. Am J Epidemiol 1978;107:538-549. 2) O'Toole SM1, Pathak N2, Toms GC2, Gelding SV2, Sivaprakasam V3. Fever, jaundice and acute renal failure. Clin Med (Lond). 2015; 15(1):58-60. 3) Pothuri P, Ahuja K, Kumar V, Lal S, Tumarinson T, Mahmood K. Leptospirosis Presenting with Rapidly Progressing Acute Renal Failure and Conjugated Hyperbilirubinemia: A Case Report. Am J Case Rep 2016; 17:567-569. 4) Chakrabarti A, Nandy M, Pal D, Mallik S. A rare case of Weil's disease with alveolar haemorrhage. Asian Pac J Trop Biomed 2014; 4 (Suppl 1): S66-S69. 5) Rathinam SR, Rathnam S, Selvaraj S, et al. Uveitis associated with an epidemic outbreak of leptospirosis. Am J Ophthalmol 1997; 124:71–79. 6) Wysocki J, Liu Y, Shores N. Leptospirosis with acute liver injury. Proceedings (Baylor University Medical Center) 2014; 27(3):257-258. 7) Hurst FP, Neff RT, Katz AR, et al. Acute Kidney injury requiring hemodialysis in patients with anicteric leptospirosis. Clin Nephrol 2009; 72:186-192. 8) Cetin BD, Harmankaya O, Hasman H, et al. Acute renal failure: A common manifestation of leptospirosis. Ren Fail 2004; 26:655-661. 9) Alventosa Mateu C, Plana Campos L, Larrey Ruíz L, et al. Gastrointestinal bleeding and acute hepatic failure by leptospirosis: an entity that should not be forgotten]. Rev Gastroenterol Peru 2017; 37:96-99. 10) Esen S, Sunbul M, Leblebicioglu H, Eroglu C, Turan D. Impact of clinical and laboratory findings on prognosis in leptospirosis. Swiss Med Wkly 2004 Jun 12; 134(23-24):347-352. 11) Dupont H, Dupont-Perdrizet D, Perie JL, Zehner-Hansen S, Jarrige B, Daijardin JB. Leptospirosis: prognostic factors associated with mortality. Clin Infect Dis. 1997; 25(3):720-724. 12) Chawla V1, Trivedi TH, Yeolekar ME. Epidemic of leptospirosis: an ICU experience. J Assoc Physicians India 2004; 52:619-22.