Araştırma Makalesi
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Yıl 2019, Cilt: 09 Sayı: 04, 137 - 143, 15.12.2019
https://doi.org/10.5799/jmid.657846

Öz

Kaynakça

  • REFERENCES 1. Chien YL, Huang FL, Huang CM, Chen PY. Clinical approach to fever of unknown origin in children. J Microbiol Immunol Infect 2017; 50(6):893-898. 2. Mouaket AE, el-Ghanim MM, Abd-el-Al YK, al-Quod N. Prolonged unexplained pyrexia: a review of 221 paediatric cases from Kuwait. Infection 1990; 18(4):226–229. 3. Cho CY, Lai CC, Lee ML, et al. Clinical analysis of fever of unknown origin in children: A 10-year experience in a northern Taiwan medical center. J Microbiol. Immunol Infect 2017; 50(1):40-45. 4. Chouchane S, Chouchane CH, Ben Meriem CH, et al. Prolonged fever in children.Retrospective study of 67 cases. Archives de Pediatrie 2004; 11(11):1319-1325. 5. Cunha BA, Lortholary O, Cunha CB. Fever of unknown origin: a clinical approach. Am J Med 2015; 128(10):1138.e1-1138.e15. 6. Nield LS, Kamat D. Fever. In: Kliegman RM, Stanton BF, St Geme JW, Schor NF, Behrman RF, editors. Nelson Textbook of Pediatrics. 19th ed. Philadelphia, PA: Saunders Elsevier; 2011, pp. e169-1-e169-3. 7. Durrack DT, Streat AC. Fever of unknown origin reexamined and redefined. Curr Clin Top infect Dis 1991; 11:35-51. 8. Tezer H, Ceyhan M, Kara A, Cengiz AB, Devrim İ, Seçmeer G. Fever of unknown origin in children: the experience of one center in Turkey. Turk J Pediatr 2012; 54(6):583–589. 9. Hassan RH, Fouda AE, Kandil SM. Fever of Unknown Origin in Children: A 6 year- Experience in a Tertiary Pediatric Egyptian Hospital. Int J Health Sci (Qassim) 2014; 8(1):13-19. 10. Cogulu O, Koturoglu G, Kurugol Z, Ozkinay F, Vardar F, Ozkinay C. Evaluation of 80 children with prolonged fever. Pediatr Int. 2003; 45(5):564-569. 11. Harrison's Fever of unknown origin. In: Longo D, Fauci A, Kasper D (Eds). Principles of Internal Medicine, 18th edition. McGraw Hill; 2012, pp:158-164. 12. Cruz Guerrero G, Navarro González J, Cintado Bueno C. [Fever of unknown origin in children]. An Esp Pediatr 1978; 11(10):683-692. [article in Spanish]. 13. Sandoval C, Pinochet C, Peña A, Rabello M, Prado A, Viviani T. Fever of unknown origin: a challenge for the pediatric infectious diseases specialist. Rev Chilena Infectol 2014; 31(1):87-91 [Abstract only, article in Spanish]. 14. Kejariwal D, Sarkar N, Chakraborti SK, Agarwal V, Roy S. Pyrexia of unknown origin: a prospective study of 100 cases. J Postgrad Med 2001; 47(2):104-107. 15. Joshi N, Rajeshwari K, Dubey AP, Singh T, Kaur R. Clinical spectrum of fever of unknown origin among Indian children. Ann Trop Paediatr 2008; 28(4):261-266. 16. Ciftdoğan DY, Bayram N, Vardar F. Brucellosis as a cause of fever of unknown origin in children admitted to a tertiary hospital in the Aegean region of Turkey. Vector Borne Zoonotic Dis 2011; 11(8):1037-1040. 17. Kim YS, Kim KR, Kang JM, Kim JM, Kim YJ. Etiology and clinical characteristics of fever of unknown origin in children: a 15-year experience in a single center. Korean J Pediatr 2017; 60(3):77-85. 18. Landge AA, Singhal T. Etiology of Fever of Unknown Origin in Children from Mumbai, India. Indian Pediatr 2018; 55(1):71-72. 19. Crump JA, Morrissey AB, Nicholson WL, et al. Etiology of Severe Non-malaria Febrile Illness in Northern Tanzania: A Prospective Cohort Study. Picardeau M, ed. PLoS Negl Trop Dis 2013; 7(7):e2324. 20. Xie T, Pan J-H, Zhang X. [Value of combined measurement of C-reactive protein, erythrocyte sedimentation rate, lactate dehydrogenase and serum ferritin in etiological diagnosis of fever of unknown origin in children]. Zhongguo Dang Dai Er Ke Za Zhi 2015;17(9):950-955. 21. Labrador J, Pérez-López E, Martín A, Cabrero M, Puig N, Díez-Campelo M. Diagnostic utility of bone marrow examination for the assessment of patients with fever of unknown origin: a 10-year single-centre experience. Intern Med J. 2014; 44(6):610-612. 22. Steele RW, Jones SM, Lowe BA, Glasier CM. Usefulness of scanning procedures for diagnosis of fever of unknown origin in children. J Pediatr 1991; 119(4):526-530.

Profile of Fever of Unknown Origin in Children and the Role of Investigation: An Observational Study

Yıl 2019, Cilt: 09 Sayı: 04, 137 - 143, 15.12.2019
https://doi.org/10.5799/jmid.657846

Öz

ABSTRACT
Objectives: Fever of Unknown Origin (FUO) in children remains difficult to diagnose. This prospective, observational study aimed to determine the clinico-etiological profile and the role of clinical procedures in establishing the diagnosis.
Methods: Children (1 month-16 years) with prolonged fever meeting the criteria of FUO were included. A detailed medical history, physical examination and laboratory tests were conducted according to an algorithm (phase I-III). Clinical procedures that were useful in obtaining final etiology were evaluated.
Results: In total, 69 children were enrolled, categorized into five groups based on etiology of FUO. Infections (31.8%) were the leading cause followed by malignancy (20.2%), connective tissue disorder and miscellaneous conditions (14.5%); undiagnosed patients (18.8%) had either a spontaneous resolution or incomplete workup. Duration of fever was 20-60 days, longer in malignancies, least in infections and mean ± SD duration between admission and a definitive diagnosis was 5.65 ± 1.06 days. Tuberculosis was the most common among the infections, systemic onset juvenile idiopathic arthritis and Common acute lymphoblastic leukemia antigen positive B cell acute lymphoblastic leukemia were common causes of connective tissue disorder and malignancy, respectively.
The diagnosis was established by Phase II (33.3%) and Phase III (34.8%) investigations. Non-invasive and invasive investigations were useful in 56.3%, and 43.7 %, respectively.
Conclusions: Infections are the most common cause of FUO in children followed by malignancy. A stepwise approach is useful in diagnosis. Infections and connective tissue disorders are diagnosed by non-invasive investigations while malignancy and miscellaneous conditions by invasive investigations. Focused clinical and diagnostic approach is mandated. J Microbiol Infect Dis 2019; 9(3):137-143.

Kaynakça

  • REFERENCES 1. Chien YL, Huang FL, Huang CM, Chen PY. Clinical approach to fever of unknown origin in children. J Microbiol Immunol Infect 2017; 50(6):893-898. 2. Mouaket AE, el-Ghanim MM, Abd-el-Al YK, al-Quod N. Prolonged unexplained pyrexia: a review of 221 paediatric cases from Kuwait. Infection 1990; 18(4):226–229. 3. Cho CY, Lai CC, Lee ML, et al. Clinical analysis of fever of unknown origin in children: A 10-year experience in a northern Taiwan medical center. J Microbiol. Immunol Infect 2017; 50(1):40-45. 4. Chouchane S, Chouchane CH, Ben Meriem CH, et al. Prolonged fever in children.Retrospective study of 67 cases. Archives de Pediatrie 2004; 11(11):1319-1325. 5. Cunha BA, Lortholary O, Cunha CB. Fever of unknown origin: a clinical approach. Am J Med 2015; 128(10):1138.e1-1138.e15. 6. Nield LS, Kamat D. Fever. In: Kliegman RM, Stanton BF, St Geme JW, Schor NF, Behrman RF, editors. Nelson Textbook of Pediatrics. 19th ed. Philadelphia, PA: Saunders Elsevier; 2011, pp. e169-1-e169-3. 7. Durrack DT, Streat AC. Fever of unknown origin reexamined and redefined. Curr Clin Top infect Dis 1991; 11:35-51. 8. Tezer H, Ceyhan M, Kara A, Cengiz AB, Devrim İ, Seçmeer G. Fever of unknown origin in children: the experience of one center in Turkey. Turk J Pediatr 2012; 54(6):583–589. 9. Hassan RH, Fouda AE, Kandil SM. Fever of Unknown Origin in Children: A 6 year- Experience in a Tertiary Pediatric Egyptian Hospital. Int J Health Sci (Qassim) 2014; 8(1):13-19. 10. Cogulu O, Koturoglu G, Kurugol Z, Ozkinay F, Vardar F, Ozkinay C. Evaluation of 80 children with prolonged fever. Pediatr Int. 2003; 45(5):564-569. 11. Harrison's Fever of unknown origin. In: Longo D, Fauci A, Kasper D (Eds). Principles of Internal Medicine, 18th edition. McGraw Hill; 2012, pp:158-164. 12. Cruz Guerrero G, Navarro González J, Cintado Bueno C. [Fever of unknown origin in children]. An Esp Pediatr 1978; 11(10):683-692. [article in Spanish]. 13. Sandoval C, Pinochet C, Peña A, Rabello M, Prado A, Viviani T. Fever of unknown origin: a challenge for the pediatric infectious diseases specialist. Rev Chilena Infectol 2014; 31(1):87-91 [Abstract only, article in Spanish]. 14. Kejariwal D, Sarkar N, Chakraborti SK, Agarwal V, Roy S. Pyrexia of unknown origin: a prospective study of 100 cases. J Postgrad Med 2001; 47(2):104-107. 15. Joshi N, Rajeshwari K, Dubey AP, Singh T, Kaur R. Clinical spectrum of fever of unknown origin among Indian children. Ann Trop Paediatr 2008; 28(4):261-266. 16. Ciftdoğan DY, Bayram N, Vardar F. Brucellosis as a cause of fever of unknown origin in children admitted to a tertiary hospital in the Aegean region of Turkey. Vector Borne Zoonotic Dis 2011; 11(8):1037-1040. 17. Kim YS, Kim KR, Kang JM, Kim JM, Kim YJ. Etiology and clinical characteristics of fever of unknown origin in children: a 15-year experience in a single center. Korean J Pediatr 2017; 60(3):77-85. 18. Landge AA, Singhal T. Etiology of Fever of Unknown Origin in Children from Mumbai, India. Indian Pediatr 2018; 55(1):71-72. 19. Crump JA, Morrissey AB, Nicholson WL, et al. Etiology of Severe Non-malaria Febrile Illness in Northern Tanzania: A Prospective Cohort Study. Picardeau M, ed. PLoS Negl Trop Dis 2013; 7(7):e2324. 20. Xie T, Pan J-H, Zhang X. [Value of combined measurement of C-reactive protein, erythrocyte sedimentation rate, lactate dehydrogenase and serum ferritin in etiological diagnosis of fever of unknown origin in children]. Zhongguo Dang Dai Er Ke Za Zhi 2015;17(9):950-955. 21. Labrador J, Pérez-López E, Martín A, Cabrero M, Puig N, Díez-Campelo M. Diagnostic utility of bone marrow examination for the assessment of patients with fever of unknown origin: a 10-year single-centre experience. Intern Med J. 2014; 44(6):610-612. 22. Steele RW, Jones SM, Lowe BA, Glasier CM. Usefulness of scanning procedures for diagnosis of fever of unknown origin in children. J Pediatr 1991; 119(4):526-530.
Toplam 1 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Research Article
Yazarlar

P. Aparna Reddy Bu kişi benim

M. Shravani Reddy Bu kişi benim

Yayımlanma Tarihi 15 Aralık 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 09 Sayı: 04

Kaynak Göster

APA Reddy, P. A., & Reddy, M. S. (2019). Profile of Fever of Unknown Origin in Children and the Role of Investigation: An Observational Study. Journal of Microbiology and Infectious Diseases, 09(04), 137-143. https://doi.org/10.5799/jmid.657846
AMA Reddy PA, Reddy MS. Profile of Fever of Unknown Origin in Children and the Role of Investigation: An Observational Study. J Microbil Infect Dis. Aralık 2019;09(04):137-143. doi:10.5799/jmid.657846
Chicago Reddy, P. Aparna, ve M. Shravani Reddy. “Profile of Fever of Unknown Origin in Children and the Role of Investigation: An Observational Study”. Journal of Microbiology and Infectious Diseases 09, sy. 04 (Aralık 2019): 137-43. https://doi.org/10.5799/jmid.657846.
EndNote Reddy PA, Reddy MS (01 Aralık 2019) Profile of Fever of Unknown Origin in Children and the Role of Investigation: An Observational Study. Journal of Microbiology and Infectious Diseases 09 04 137–143.
IEEE P. A. Reddy ve M. S. Reddy, “Profile of Fever of Unknown Origin in Children and the Role of Investigation: An Observational Study”, J Microbil Infect Dis, c. 09, sy. 04, ss. 137–143, 2019, doi: 10.5799/jmid.657846.
ISNAD Reddy, P. Aparna - Reddy, M. Shravani. “Profile of Fever of Unknown Origin in Children and the Role of Investigation: An Observational Study”. Journal of Microbiology and Infectious Diseases 09/04 (Aralık 2019), 137-143. https://doi.org/10.5799/jmid.657846.
JAMA Reddy PA, Reddy MS. Profile of Fever of Unknown Origin in Children and the Role of Investigation: An Observational Study. J Microbil Infect Dis. 2019;09:137–143.
MLA Reddy, P. Aparna ve M. Shravani Reddy. “Profile of Fever of Unknown Origin in Children and the Role of Investigation: An Observational Study”. Journal of Microbiology and Infectious Diseases, c. 09, sy. 04, 2019, ss. 137-43, doi:10.5799/jmid.657846.
Vancouver Reddy PA, Reddy MS. Profile of Fever of Unknown Origin in Children and the Role of Investigation: An Observational Study. J Microbil Infect Dis. 2019;09(04):137-43.