Araştırma Makalesi
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Yıl 2022, Cilt: 12 Sayı: 02, 38 - 46, 15.06.2022
https://doi.org/10.5799/jmid.1130058

Öz

Kaynakça

  • 1. Mei Y, Luo D, Wei S, Liao X, Pan Y, Yang X, Lin Y: Obstetric management of COVID-19 in pregnant women. Front Microbiol 2020, 11:1186.
  • 2. Di Mascio D, Khalil A, Saccone G, Rizzo G, Buca D, Liberati M, Vecchiet J, Nappi L, Scambia G, Berghella V: Outcome of coronavirus spectrum infections (SARS, MERS, COVID-19) during pregnancy: a systematic review and meta-analysis. American journal of obstetrics & gynecology MFM 2020, 2(2):100107.
  • 3. Wong SF, Chow KM, Leung TN, et al. Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome. Am J Obstetr Gynecol 2004, 191(1):292-297.
  • 4. Callaghan WM, Creanga AA, Jamieson DJ. Pregnancy-related mortality resulting from influenza in the United States during the 2009–2010 pandemic. Obstetr Gynecol 2015, 126(3):486.
  • 5. Thompson JL, Nguyen LM, Noble KN, Aronoff DM. COVID-19-related disease severity in pregnancy. Am J Reprod Immunol 2020, 84(5):e13339.
  • 6. Ellington S, Strid P, Tong VT, et al. Characteristics of women of reproductive age with laboratory-confirmed SARS-CoV-2 infection by pregnancy status-United States, January 22–June 7, 2020. MMWR 2020, 69(25):769.
  • 7. Li N, Han L, Peng M, Lv Y, et al: Maternal and Neonatal Outcomes of Pregnant Women With Coronavirus Disease 2019 (COVID-19) Pneumonia: A Case-Control Study. Clin Infect Dis 2020, 71(16):2035-2041.
  • 8. Clinical Spectrum of SARS-CoV-2 Infection [https://www.covid19treatmentguidelines.nih.gov/overview/clinical-spectrum/]
  • 9. Guan W-j, Ni Z-y, Hu Y, et al: Clinical Characteristics of Coronavirus Disease 2019 in China. N Eng J Med 2020, 382(18):1708-1720.
  • 10. Lu L, Zhong W, Bian Z, et al. A comparison of mortality-related risk factors of COVID-19, SARS, and MERS: A systematic review and meta-analysis. J Infect 2020.
  • 11. Vouga M, Favre G, Martinez-Perez O, Pomar L, Acebal LF, Abascal-Saiz A, Hernandez MRV, Hcini N, Lambert V, Carles G: Maternal outcomes and risk factors for COVID-19 severity among pregnant women. Scient Report 2021, 11(1):1-11.
  • 12. Wastnedge EAN, Reynolds RM, van Boeckel SR, et al. Pregnancy and COVID-19. Physiol Rev 2021, 101(1):303-318.
  • 13. Khalil A, Hill R, Ladhani S, Pattisson K, O’Brien P: Severe acute respiratory syndrome coronavirus 2 in pregnancy: symptomatic pregnant women are only the tip of the iceberg. Am J Obstetr Gynecol 2020, 223(2):296-297.
  • 14. Pineles BL, Goodman KE, Pineles L, et al. In-Hospital Mortality in a Cohort of Hospitalized Pregnant and Nonpregnant Patients With COVID-19. Ann Intern Med 2021.
  • 15. Villar J, Ariff S, Gunier RB, et al. Maternal and neonatal morbidity and mortality among pregnant women with and without COVID-19 infection: the INTERCOVID multinational cohort study. JAMA Pediatr 2021; 175(8):817-826.
  • 16. Blitz M, Rochelson B, Meirowitz N, Prasannan L, Rafael T: Maternal mortality among women with coronavirus disease 2019. Am J Obstetr Gynecol 2019; 223(4):595-599.e5.
  • 17. Chen L, Li Q, Zheng D, et al: Clinical Characteristics of Pregnant Women with Covid-19 in Wuhan, China. N Eng J Med 2020; 382(25):e100.
  • 18. Wu Z, McGoogan JM: Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA 2020; 323(13):1239-1242.
  • 19. Chen H, Guo J, Wang C, et al: Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet 2020; 395(10226):809-815.
  • 20. Barry M, Barry MA: Coronaviruses in pregnant women in Saudi Arabia: A systematic comparative review of MERS-CoV and SARS-CoV-2. Asian Pacific J Reproduct 2021; 10(3):97.
  • 21. Koyuncu K, Yasemin A, Sakin Ö, et al. COVID-19 in pregnant women-a retrospective cohort study. Samsun Sağlık Bilimleri Dergisi, 6(1):181-186. (Turkish)
  • 22. Özdemir YE, Balkan İİ, Bayramlar OF, et al: Clinical Characteristics of Mild-Moderate COVID-19 Patients and Risk Factors for the Development of Pneumonia. Mikrobiol Bullet 2021, 55(3):342-356.
  • 23. Abu-Amara J, Szpecht D, Al-Saad SR, Karbowski LM: Contracting COVID-19 in the first and second trimester of pregnancy: what we know–a concise qualitative systematic review. Arch Med Sci 2021;17(6):1548-1557.
  • 24. Zhu H, Wang L, Fang C, et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Transl Pediatr 2020; 9(1):51-60.
  • 25. Manal M, Abdelilah E, Mohammed M, Rajae A, Amine BM, Houssam B, Naima A, Brahim H: Lymphopenia in Covid-19: A single center retrospective study of 589 cases. Ann Med Surg (Lond) 2021; 69:102816.
  • 26. Tavakolpour S, Rakhshandehroo T, Wei EX, Rashidian M. Lymphopenia during the COVID-19 infection: What it shows and what can be learned. Immunol Lett 2020; 225:31-32.
  • 27. Terpos E, Ntanasis‐Stathopoulos I, Elalamy I, et al. Hematological findings and complications of COVID‐19. Am J Hematol 2020; 95(7):834-847.
  • 28. Karimi L, Makvandi S, Vahedian-Azimi A, Sathyapalan T, Sahebkar A: Effect of COVID-19 on Mortality of Pregnant and Postpartum Women: A Systematic Review and Meta-Analysis. J Pregnancy 2021; 2021:8870129.
  • 29. Takemoto MLS, Menezes MO, et al. The tragedy of COVID-19 in Brazil: 124 maternal deaths and counting. Int J Gynaecol Obstet 2020; 151(1):154-156.
  • 30. Ferrazzi E, Frigerio L, Savasi V, et al. Vaginal delivery in SARS‐CoV‐2‐infected pregnant women in Northern Italy: a retrospective analysis. BJOG: An Intern J of Obstetr Gynaecol 2020; 127(9):1116-1121.
  • 31. Zhang L, Jiang Y, Wei M, et al. Analysis of the pregnancy outcomes in pregnant women with COVID-19 in Hubei Province. Zhonghua Fu Chan Ke Za Zhi 2020; 55(3):166-171. (Chinese)

Clinical Manifestation and Characteristics of COVID-19 in Pregnants: A Retrospective, Single-Center Study

Yıl 2022, Cilt: 12 Sayı: 02, 38 - 46, 15.06.2022
https://doi.org/10.5799/jmid.1130058

Öz

Objectives: Along with the COVID-19 pandemic, pregnant women have experienced COVID-19 symptoms of varying severity. Therefore, we aimed to show the clinical, laboratory, and radiological findings for three different trimesters in pregnant women diagnosed with COVID-19.
Methods: All hospitalized pregnant women with positive SARS-CoV-2 nucleic acid tests were included in this study. The severity of the disease was classified using the NIH Classification of Severity of Disease.
Results: None of the 206 participants were vaccinated. The number of asymptomatic or presymptomatic patients, those with mild, moderate, and severe disease, was 73(35.4%), 59(28.6%), 68 (33.1%), and 6 (2.9%), respectively. The gestational age of symptomatic patients was lower than that of asymptomatic patients (29 vs. 37 weeks) (p= 0.001). The incidence of pneumonia increased with the trimester of pregnancy increased (p<0.001). Sixty-six of the pregnancies (32.0%) ended with term births, and 11 (0.5%) gave premature birth. Three pregnancies resulted in miscarriage (1.4%), and one(0.4%) resulted in intrauterine fetal death. Of the preterm deliveries, nine(64.3%) had pneumonia. There was no significant relationship between the disease severity and delivery time (p=0.075), but a significant relationship between the disease severity and the delivery mode. Expected vaginal delivery occurred in 18 asymptomatic patients (72%), whereas cesarian/section was performed in 75.6% (n=31) of symptomatic patients (p<0.001).
Conclusion: This study reflects the natural course of COVID-19 since our patients were not vaccinated. We think the results will be better with the increase in vaccination rates.

Kaynakça

  • 1. Mei Y, Luo D, Wei S, Liao X, Pan Y, Yang X, Lin Y: Obstetric management of COVID-19 in pregnant women. Front Microbiol 2020, 11:1186.
  • 2. Di Mascio D, Khalil A, Saccone G, Rizzo G, Buca D, Liberati M, Vecchiet J, Nappi L, Scambia G, Berghella V: Outcome of coronavirus spectrum infections (SARS, MERS, COVID-19) during pregnancy: a systematic review and meta-analysis. American journal of obstetrics & gynecology MFM 2020, 2(2):100107.
  • 3. Wong SF, Chow KM, Leung TN, et al. Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome. Am J Obstetr Gynecol 2004, 191(1):292-297.
  • 4. Callaghan WM, Creanga AA, Jamieson DJ. Pregnancy-related mortality resulting from influenza in the United States during the 2009–2010 pandemic. Obstetr Gynecol 2015, 126(3):486.
  • 5. Thompson JL, Nguyen LM, Noble KN, Aronoff DM. COVID-19-related disease severity in pregnancy. Am J Reprod Immunol 2020, 84(5):e13339.
  • 6. Ellington S, Strid P, Tong VT, et al. Characteristics of women of reproductive age with laboratory-confirmed SARS-CoV-2 infection by pregnancy status-United States, January 22–June 7, 2020. MMWR 2020, 69(25):769.
  • 7. Li N, Han L, Peng M, Lv Y, et al: Maternal and Neonatal Outcomes of Pregnant Women With Coronavirus Disease 2019 (COVID-19) Pneumonia: A Case-Control Study. Clin Infect Dis 2020, 71(16):2035-2041.
  • 8. Clinical Spectrum of SARS-CoV-2 Infection [https://www.covid19treatmentguidelines.nih.gov/overview/clinical-spectrum/]
  • 9. Guan W-j, Ni Z-y, Hu Y, et al: Clinical Characteristics of Coronavirus Disease 2019 in China. N Eng J Med 2020, 382(18):1708-1720.
  • 10. Lu L, Zhong W, Bian Z, et al. A comparison of mortality-related risk factors of COVID-19, SARS, and MERS: A systematic review and meta-analysis. J Infect 2020.
  • 11. Vouga M, Favre G, Martinez-Perez O, Pomar L, Acebal LF, Abascal-Saiz A, Hernandez MRV, Hcini N, Lambert V, Carles G: Maternal outcomes and risk factors for COVID-19 severity among pregnant women. Scient Report 2021, 11(1):1-11.
  • 12. Wastnedge EAN, Reynolds RM, van Boeckel SR, et al. Pregnancy and COVID-19. Physiol Rev 2021, 101(1):303-318.
  • 13. Khalil A, Hill R, Ladhani S, Pattisson K, O’Brien P: Severe acute respiratory syndrome coronavirus 2 in pregnancy: symptomatic pregnant women are only the tip of the iceberg. Am J Obstetr Gynecol 2020, 223(2):296-297.
  • 14. Pineles BL, Goodman KE, Pineles L, et al. In-Hospital Mortality in a Cohort of Hospitalized Pregnant and Nonpregnant Patients With COVID-19. Ann Intern Med 2021.
  • 15. Villar J, Ariff S, Gunier RB, et al. Maternal and neonatal morbidity and mortality among pregnant women with and without COVID-19 infection: the INTERCOVID multinational cohort study. JAMA Pediatr 2021; 175(8):817-826.
  • 16. Blitz M, Rochelson B, Meirowitz N, Prasannan L, Rafael T: Maternal mortality among women with coronavirus disease 2019. Am J Obstetr Gynecol 2019; 223(4):595-599.e5.
  • 17. Chen L, Li Q, Zheng D, et al: Clinical Characteristics of Pregnant Women with Covid-19 in Wuhan, China. N Eng J Med 2020; 382(25):e100.
  • 18. Wu Z, McGoogan JM: Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA 2020; 323(13):1239-1242.
  • 19. Chen H, Guo J, Wang C, et al: Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet 2020; 395(10226):809-815.
  • 20. Barry M, Barry MA: Coronaviruses in pregnant women in Saudi Arabia: A systematic comparative review of MERS-CoV and SARS-CoV-2. Asian Pacific J Reproduct 2021; 10(3):97.
  • 21. Koyuncu K, Yasemin A, Sakin Ö, et al. COVID-19 in pregnant women-a retrospective cohort study. Samsun Sağlık Bilimleri Dergisi, 6(1):181-186. (Turkish)
  • 22. Özdemir YE, Balkan İİ, Bayramlar OF, et al: Clinical Characteristics of Mild-Moderate COVID-19 Patients and Risk Factors for the Development of Pneumonia. Mikrobiol Bullet 2021, 55(3):342-356.
  • 23. Abu-Amara J, Szpecht D, Al-Saad SR, Karbowski LM: Contracting COVID-19 in the first and second trimester of pregnancy: what we know–a concise qualitative systematic review. Arch Med Sci 2021;17(6):1548-1557.
  • 24. Zhu H, Wang L, Fang C, et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Transl Pediatr 2020; 9(1):51-60.
  • 25. Manal M, Abdelilah E, Mohammed M, Rajae A, Amine BM, Houssam B, Naima A, Brahim H: Lymphopenia in Covid-19: A single center retrospective study of 589 cases. Ann Med Surg (Lond) 2021; 69:102816.
  • 26. Tavakolpour S, Rakhshandehroo T, Wei EX, Rashidian M. Lymphopenia during the COVID-19 infection: What it shows and what can be learned. Immunol Lett 2020; 225:31-32.
  • 27. Terpos E, Ntanasis‐Stathopoulos I, Elalamy I, et al. Hematological findings and complications of COVID‐19. Am J Hematol 2020; 95(7):834-847.
  • 28. Karimi L, Makvandi S, Vahedian-Azimi A, Sathyapalan T, Sahebkar A: Effect of COVID-19 on Mortality of Pregnant and Postpartum Women: A Systematic Review and Meta-Analysis. J Pregnancy 2021; 2021:8870129.
  • 29. Takemoto MLS, Menezes MO, et al. The tragedy of COVID-19 in Brazil: 124 maternal deaths and counting. Int J Gynaecol Obstet 2020; 151(1):154-156.
  • 30. Ferrazzi E, Frigerio L, Savasi V, et al. Vaginal delivery in SARS‐CoV‐2‐infected pregnant women in Northern Italy: a retrospective analysis. BJOG: An Intern J of Obstetr Gynaecol 2020; 127(9):1116-1121.
  • 31. Zhang L, Jiang Y, Wei M, et al. Analysis of the pregnancy outcomes in pregnant women with COVID-19 in Hubei Province. Zhonghua Fu Chan Ke Za Zhi 2020; 55(3):166-171. (Chinese)
Toplam 31 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Research Article
Yazarlar

Esmeray Mutlu Yılmaz Bu kişi benim

Eda Koksal Bu kişi benim

Gökhan Unver Bu kişi benim

Sercan Serin

Yayımlanma Tarihi 15 Haziran 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 12 Sayı: 02

Kaynak Göster

APA Mutlu Yılmaz, E., Koksal, E., Unver, G., Serin, S. (2022). Clinical Manifestation and Characteristics of COVID-19 in Pregnants: A Retrospective, Single-Center Study. Journal of Microbiology and Infectious Diseases, 12(02), 38-46. https://doi.org/10.5799/jmid.1130058
AMA Mutlu Yılmaz E, Koksal E, Unver G, Serin S. Clinical Manifestation and Characteristics of COVID-19 in Pregnants: A Retrospective, Single-Center Study. J Microbil Infect Dis. Haziran 2022;12(02):38-46. doi:10.5799/jmid.1130058
Chicago Mutlu Yılmaz, Esmeray, Eda Koksal, Gökhan Unver, ve Sercan Serin. “Clinical Manifestation and Characteristics of COVID-19 in Pregnants: A Retrospective, Single-Center Study”. Journal of Microbiology and Infectious Diseases 12, sy. 02 (Haziran 2022): 38-46. https://doi.org/10.5799/jmid.1130058.
EndNote Mutlu Yılmaz E, Koksal E, Unver G, Serin S (01 Haziran 2022) Clinical Manifestation and Characteristics of COVID-19 in Pregnants: A Retrospective, Single-Center Study. Journal of Microbiology and Infectious Diseases 12 02 38–46.
IEEE E. Mutlu Yılmaz, E. Koksal, G. Unver, ve S. Serin, “Clinical Manifestation and Characteristics of COVID-19 in Pregnants: A Retrospective, Single-Center Study”, J Microbil Infect Dis, c. 12, sy. 02, ss. 38–46, 2022, doi: 10.5799/jmid.1130058.
ISNAD Mutlu Yılmaz, Esmeray vd. “Clinical Manifestation and Characteristics of COVID-19 in Pregnants: A Retrospective, Single-Center Study”. Journal of Microbiology and Infectious Diseases 12/02 (Haziran 2022), 38-46. https://doi.org/10.5799/jmid.1130058.
JAMA Mutlu Yılmaz E, Koksal E, Unver G, Serin S. Clinical Manifestation and Characteristics of COVID-19 in Pregnants: A Retrospective, Single-Center Study. J Microbil Infect Dis. 2022;12:38–46.
MLA Mutlu Yılmaz, Esmeray vd. “Clinical Manifestation and Characteristics of COVID-19 in Pregnants: A Retrospective, Single-Center Study”. Journal of Microbiology and Infectious Diseases, c. 12, sy. 02, 2022, ss. 38-46, doi:10.5799/jmid.1130058.
Vancouver Mutlu Yılmaz E, Koksal E, Unver G, Serin S. Clinical Manifestation and Characteristics of COVID-19 in Pregnants: A Retrospective, Single-Center Study. J Microbil Infect Dis. 2022;12(02):38-46.