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Role of miRNAs in Immune Regulation And Bacterial Infections

Yıl 2023, Cilt: 13 Sayı: 01, 1 - 7, 15.03.2023
https://doi.org/10.5799/jmid.1264855

Öz

Micro RNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the post-transcriptional level. The miRNA in the RNA-induced silencing complex acts as a guide strand and binds the target mRNA. Subsequently, the gene is silenced either by cleaving the target mRNA or repressing the translation. Since the discovery of the first miRNA three decades ago, more than 2000 human miRNAs have been discovered. It is known to regulate hundreds of genes in various physiological and pathophysiological processes, including the development and function of immunologically essential cells. miR-155 plays a vital role in the function of T helper 1, 17, and T regulatory cells. miR-24 positively regulates the function of T helper 1, 17, and T regulatory cells, whereas miR-23 and 27 have a negative regulatory effect. miR-223 regulates the differentiation of neutrophils and monocytes. The role of miRNAs in bacterial infections came to light in 2006 after discovering miR-163 as a negative regulator of defense response in Arabidopsis thaliana infected with Pseudomonas syringae. During bacterial infection in the host, aberrant expression of several miRNAs was discovered. miR-155 was found to be the most commonly dysregulated miRNA in bacterial infections such as Helicobacter pylori, Staphylococcus aureus, Listeria monocytogenes, Mycobacterium tuberculosis, and Chlamydia trachomatis. Therefore, miRNAs can be utilized as a diagnostic and prognostic tool for bacterial infections. J Microbiol Infect Dis 2022; 12(4):1-7.

Yıl 2023, Cilt: 13 Sayı: 01, 1 - 7, 15.03.2023
https://doi.org/10.5799/jmid.1264855

Öz

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Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Research Article
Yazarlar

P. Shaik Syed Alı Bu kişi benim

Yayımlanma Tarihi 15 Mart 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 13 Sayı: 01

Kaynak Göster

APA Alı, P. S. S. (2023). Role of miRNAs in Immune Regulation And Bacterial Infections. Journal of Microbiology and Infectious Diseases, 13(01), 1-7. https://doi.org/10.5799/jmid.1264855
AMA Alı PSS. Role of miRNAs in Immune Regulation And Bacterial Infections. J Microbil Infect Dis. Mart 2023;13(01):1-7. doi:10.5799/jmid.1264855
Chicago Alı, P. Shaik Syed. “Role of MiRNAs in Immune Regulation And Bacterial Infections”. Journal of Microbiology and Infectious Diseases 13, sy. 01 (Mart 2023): 1-7. https://doi.org/10.5799/jmid.1264855.
EndNote Alı PSS (01 Mart 2023) Role of miRNAs in Immune Regulation And Bacterial Infections. Journal of Microbiology and Infectious Diseases 13 01 1–7.
IEEE P. S. S. Alı, “Role of miRNAs in Immune Regulation And Bacterial Infections”, J Microbil Infect Dis, c. 13, sy. 01, ss. 1–7, 2023, doi: 10.5799/jmid.1264855.
ISNAD Alı, P. Shaik Syed. “Role of MiRNAs in Immune Regulation And Bacterial Infections”. Journal of Microbiology and Infectious Diseases 13/01 (Mart 2023), 1-7. https://doi.org/10.5799/jmid.1264855.
JAMA Alı PSS. Role of miRNAs in Immune Regulation And Bacterial Infections. J Microbil Infect Dis. 2023;13:1–7.
MLA Alı, P. Shaik Syed. “Role of MiRNAs in Immune Regulation And Bacterial Infections”. Journal of Microbiology and Infectious Diseases, c. 13, sy. 01, 2023, ss. 1-7, doi:10.5799/jmid.1264855.
Vancouver Alı PSS. Role of miRNAs in Immune Regulation And Bacterial Infections. J Microbil Infect Dis. 2023;13(01):1-7.