BibTex RIS Kaynak Göster

Invasive orbital aspergillosis in an apparently immunocompetent host without evidence sinusitis

Yıl 2012, Cilt: 2 Sayı: 03, 113 - 116, 01.09.2012
https://doi.org/10.5799/ahinjs.02.2012.03.0054

Öz

Jennifer Primeggia, George Cyriac, Princy Kumar Invasive aspergillosis is uncommon in healthy individuals. We report a case of Aspergillus fumigatus orbital cellulitis with intracranial extension in an apparently immunocompetent patient with a history of benign lymphoid hyperplasia of the lacrimal gland. A 68 year-old man with no signiicant past medical history underwent orbitotomy and biopsy of a lacrimal gland mass. Pathology showed benign lymphoid hyperplasia of the lacrimal gland and he completed radiation therapy. Three months after orbitotomy and one month after completion of radiation therapy, he presented with orbital cellulitis. Brain magnetic resonance imaging demonstrated invasion into the frontal lobe. Clinical and radiographic indings failed to improve with prolonged antibiotic therapy; transcranial orbitotomy with right frontal craniotomy for abscess drainage and orbit washout was performed. Intraoperative cultures grew Aspergillus fumigatus. The patient completed a six month course of therapy with oral voriconazole and has remained free from relapse with long-term follow-up. Eficacy of voriconazole was guided by serial imaging and voriconazole trough levels. Aspergillus may cause invasive disease in immunocompetent hosts, even without evidence of sinusitis, and should be considered in the dif- ferential diagnosis when patients do not demonstrate clinical improvement with antibiotic therapy.

Kaynakça

  • Segal BH, Walsh TJ. Current approaches to diagnosis and treatment of invasive aspergillosis. Am J Respir Crit Care Med 2006; 173:707-717.
  • Liu IT, Kao SC, Wang AG, Tsai CC, Liang CK, Hsu WM. Pre- septal and orbital cellulitis: a 10-year review of hospitalized patients. J Chin Med Assoc 2006; 69:415-422.
  • Segal BH. Aspergillosis. N Eng J Med 2009;360:1870-1884.
  • Knop E and Knop N. The role of eye-associated lymphoid tis- sue in corneal immune protection. J Anat 2005; 206:271-285.
  • Carlisle RT, Fredrick GT. Preseptal and orbital cellulitis. Hospi- tal Physician 2006; 42:15-19.
  • Levin LA, Avery R, Shore JW, Woog JJ, Baker AS. The spec- trum of orbital aspergillosis: a clinicopathological review. Surv Ophthalmol 1996; 41:142-154.
  • Polito E, Leccisotti A. Prognosis of orbital lymphoid hyperpla- sia. Graefes Arch Clin Exp Ophthalmol 1996; 234:150-154.
  • Kennerdell JS, Flores NE, Hartsock RJ. Low-dose radiothera- py for lymphoid lesions of the orbit and ocular adnexa. Oph- thal Plast Reconstr Surg 1999; 15:129-133.
  • De Cicco L, Cella L, Liuzzi R, Solla R, Farella A, Punzo G, et al. Radiation therapy in primary orbital lymphoma: a single institution retrospective analysis. Radiat Oncol 2009; 4:60.
  • Nicolle MC, Benet T, Thiebaut A, et al. Invasive aspergil- losis in patients with hematologic malignancies: incidence and description of 127 cases enrolled in a single institution prospective survey from 2004 to 2009. Haematologica 2011; 96:1685-1691.
  • Pagano L, Caira M, Candoni A, et al. The epidemiology of fungal infections in patients with hematologic malignancies: the SEIFEM-2004 study. Haematologica 2006; 91:1068- 1075.
  • Herbrecht R, Moghaddam A, Mahmal L, Natarajan-Ame S, Fornecker LM, Letscher-Bru V. Invasive aspergillosis in the hematologic and immunologic patient: new findings and key questions in leukemia. Med Mycol 2005; 43:S239-S242.
  • Lortholary O, Ascioglu S, Moreau P, et al. Invasive aspergil- losis as an opportunistic infection in nonallografted patients with multiple myeloma: a European organization for research and treatment of cancer. Clin Infect Dis 2000; 30:41-46.
  • Perfect JR, Cox GM, Lee JY, et al. The impact of culture isolation of aspergillus species: a hospital-based survey of aspergillosis 2001; 33:1824-1833.
  • Clancy CJ, Nguyen MH. Invasive sinus aspergillosis in ap- parently immunocompetent hosts. J Infect 1998; 37:229-240.
  • Siddiqui AA, Shah AA, Bashir SH. Craniocerebral aspergil- losis of sinonasal origin in immunocompetent patients: clini- cal spectrum and outcome in 25 cases. Neurosurgery; 2004; 55:602-611.
  • Schwartz S, Reisman A, Troke PF. The efficacy of voricon- azole treatment of 192 fungal central nervous system infec- tions: a retrospective analysis. Infection 2011; 39:201-210.

Invasive orbital aspergillosis in an apparently immunocompetent host without evidence sinusitis

Yıl 2012, Cilt: 2 Sayı: 03, 113 - 116, 01.09.2012
https://doi.org/10.5799/ahinjs.02.2012.03.0054

Öz

Kaynakça

  • Segal BH, Walsh TJ. Current approaches to diagnosis and treatment of invasive aspergillosis. Am J Respir Crit Care Med 2006; 173:707-717.
  • Liu IT, Kao SC, Wang AG, Tsai CC, Liang CK, Hsu WM. Pre- septal and orbital cellulitis: a 10-year review of hospitalized patients. J Chin Med Assoc 2006; 69:415-422.
  • Segal BH. Aspergillosis. N Eng J Med 2009;360:1870-1884.
  • Knop E and Knop N. The role of eye-associated lymphoid tis- sue in corneal immune protection. J Anat 2005; 206:271-285.
  • Carlisle RT, Fredrick GT. Preseptal and orbital cellulitis. Hospi- tal Physician 2006; 42:15-19.
  • Levin LA, Avery R, Shore JW, Woog JJ, Baker AS. The spec- trum of orbital aspergillosis: a clinicopathological review. Surv Ophthalmol 1996; 41:142-154.
  • Polito E, Leccisotti A. Prognosis of orbital lymphoid hyperpla- sia. Graefes Arch Clin Exp Ophthalmol 1996; 234:150-154.
  • Kennerdell JS, Flores NE, Hartsock RJ. Low-dose radiothera- py for lymphoid lesions of the orbit and ocular adnexa. Oph- thal Plast Reconstr Surg 1999; 15:129-133.
  • De Cicco L, Cella L, Liuzzi R, Solla R, Farella A, Punzo G, et al. Radiation therapy in primary orbital lymphoma: a single institution retrospective analysis. Radiat Oncol 2009; 4:60.
  • Nicolle MC, Benet T, Thiebaut A, et al. Invasive aspergil- losis in patients with hematologic malignancies: incidence and description of 127 cases enrolled in a single institution prospective survey from 2004 to 2009. Haematologica 2011; 96:1685-1691.
  • Pagano L, Caira M, Candoni A, et al. The epidemiology of fungal infections in patients with hematologic malignancies: the SEIFEM-2004 study. Haematologica 2006; 91:1068- 1075.
  • Herbrecht R, Moghaddam A, Mahmal L, Natarajan-Ame S, Fornecker LM, Letscher-Bru V. Invasive aspergillosis in the hematologic and immunologic patient: new findings and key questions in leukemia. Med Mycol 2005; 43:S239-S242.
  • Lortholary O, Ascioglu S, Moreau P, et al. Invasive aspergil- losis as an opportunistic infection in nonallografted patients with multiple myeloma: a European organization for research and treatment of cancer. Clin Infect Dis 2000; 30:41-46.
  • Perfect JR, Cox GM, Lee JY, et al. The impact of culture isolation of aspergillus species: a hospital-based survey of aspergillosis 2001; 33:1824-1833.
  • Clancy CJ, Nguyen MH. Invasive sinus aspergillosis in ap- parently immunocompetent hosts. J Infect 1998; 37:229-240.
  • Siddiqui AA, Shah AA, Bashir SH. Craniocerebral aspergil- losis of sinonasal origin in immunocompetent patients: clini- cal spectrum and outcome in 25 cases. Neurosurgery; 2004; 55:602-611.
  • Schwartz S, Reisman A, Troke PF. The efficacy of voricon- azole treatment of 192 fungal central nervous system infec- tions: a retrospective analysis. Infection 2011; 39:201-210.
Toplam 17 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Olgu Sunumu
Yazarlar

Jennifer Primeggia Bu kişi benim

George Cyriac Bu kişi benim

Princy Kumar Bu kişi benim

Yayımlanma Tarihi 1 Eylül 2012
Yayımlandığı Sayı Yıl 2012 Cilt: 2 Sayı: 03

Kaynak Göster

APA Primeggia, J., Cyriac, G., & Kumar, P. (2012). Invasive orbital aspergillosis in an apparently immunocompetent host without evidence sinusitis. Journal of Microbiology and Infectious Diseases, 2(03), 113-116. https://doi.org/10.5799/ahinjs.02.2012.03.0054
AMA Primeggia J, Cyriac G, Kumar P. Invasive orbital aspergillosis in an apparently immunocompetent host without evidence sinusitis. J Microbil Infect Dis. Eylül 2012;2(03):113-116. doi:10.5799/ahinjs.02.2012.03.0054
Chicago Primeggia, Jennifer, George Cyriac, ve Princy Kumar. “Invasive Orbital Aspergillosis in an Apparently Immunocompetent Host Without Evidence Sinusitis”. Journal of Microbiology and Infectious Diseases 2, sy. 03 (Eylül 2012): 113-16. https://doi.org/10.5799/ahinjs.02.2012.03.0054.
EndNote Primeggia J, Cyriac G, Kumar P (01 Eylül 2012) Invasive orbital aspergillosis in an apparently immunocompetent host without evidence sinusitis. Journal of Microbiology and Infectious Diseases 2 03 113–116.
IEEE J. Primeggia, G. Cyriac, ve P. Kumar, “Invasive orbital aspergillosis in an apparently immunocompetent host without evidence sinusitis”, J Microbil Infect Dis, c. 2, sy. 03, ss. 113–116, 2012, doi: 10.5799/ahinjs.02.2012.03.0054.
ISNAD Primeggia, Jennifer vd. “Invasive Orbital Aspergillosis in an Apparently Immunocompetent Host Without Evidence Sinusitis”. Journal of Microbiology and Infectious Diseases 2/03 (Eylül 2012), 113-116. https://doi.org/10.5799/ahinjs.02.2012.03.0054.
JAMA Primeggia J, Cyriac G, Kumar P. Invasive orbital aspergillosis in an apparently immunocompetent host without evidence sinusitis. J Microbil Infect Dis. 2012;2:113–116.
MLA Primeggia, Jennifer vd. “Invasive Orbital Aspergillosis in an Apparently Immunocompetent Host Without Evidence Sinusitis”. Journal of Microbiology and Infectious Diseases, c. 2, sy. 03, 2012, ss. 113-6, doi:10.5799/ahinjs.02.2012.03.0054.
Vancouver Primeggia J, Cyriac G, Kumar P. Invasive orbital aspergillosis in an apparently immunocompetent host without evidence sinusitis. J Microbil Infect Dis. 2012;2(03):113-6.