An unusual cause of cervical lymphadenopathy: Kikuchi-Fujimoto disease

Yıl 2012, Cilt: 2 Sayı: 01, 21 - 25, 01.03.2012

Mehmet Uluğ Vahap Aslan

https://doi.org/10.5799/ahinjs.02.2012.01.0036

Öz

Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is an uncommon clinical and pathological self-limited feature of benign prognosis that may mimic many other diseases diagnosed chiefly in young adults. The etiology of the disease is unknown although several investigators postulate viral, parasitic and autoimmune etiologies. The most common symptoms are cervical lymphadenopathy and fever. Diagnosis is usually rendered with excisional biopsy of lymph nodes and through histopathological findings. Non-steroidal anti-inflammatory drugs are used for the treatment. In this report, two cases of KFD without any associated infectious and/or non-infectious conditions were presented.

Anahtar Kelimeler

Kikuchi Fujimoto Disease, histiocytic necrotizing lymphadenitis, lymphadenitis

An unusual cause of cervical lymphadenopathy: Kikuchi-Fujimoto disease

Öz

Anahtar Kelimeler

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Kaynakça

• Bosch X, Guilabert A. Kikuchi-Fujimoto Disease. Orphanet J Rare Dis 2006; 1: 18.
• Lee KY, Yeon YH, Lee BC. Kikuchi-Fujimoto disease with pro- longed fever in children. Pediatrics 2004; 114: e752-e756.
• Küçükardalı Y, Solmazgül E, Kunter E, Öncül O, Yıldırım Ş, Kaplan M. Kikuchi-Fujimoto Disease: analysis of 244 cases. Clin Rheumatol 2007; 26: 50-54.
• Duskin-Bitan H, Kivity S, Olchovsky D, Schiby G, Ezra D, Mouallem M. Kikuchi-Fujimoto disease. Isr Med Assoc J. 2010; 12: 617-621.
• Yılmaz M, Camcı C, Sarı I, et al. Histiocytic necrotizing lymph- adenitis (Kikuchi-Fujimoto’s Disease) mimicking Systemic Lupus Erythematosus: a review of two cases. Lupus 2006; 15:384-387.
• Köybasi S, Saydam L, Güngen Y. Histiocytic necrotizing lymph- adenitis of the neck. Am J Otolaryngol 2003; 24: 344-347.
• Altuntaş F, Sarı İ, Canöz Ö, et al. Kikuchi-Fujimoto Disease: A rare but important cause of fever and lymphadenopathy in pregnant women. Am J Hematol 2006; 81: 118-120.
• Tanaka T, Ohmori M, Yasunaga S, Ohshima K, Kikuchi M, Sa- sazuki T. DNA typing of HLA class II genes (HLA-DR, -DQ and -DP) in Japanese patients with histiocytic necrotizing lymphadenitis (Kikuchi’s disease). Tissue Antigens 1999; 54: 246-253.
• Primrose WJ, Napier SS, Primrose AJ. Kikuchi-Fujimoto dis- ease (cervical subacute necrotizing lymphadenitis): An im- portant benign disease often masquerading as lymphoma. Ulster Med J 2009; 78: 134-136.
• Ifeacho S, Aung T, Akinsola M. Kikuchi-Fujimoto’s Disease: A case report and review of the literature. Cases J 2008; 1: 187.
• Parappil A, Rifaath AA, Doi SAR, Pathan E, Surrun SK. Py- rexia of unknown origin: Kikuchi-Fujimoto’s Disease. Clin In- fect Dis 2004; 39: 138-143.
• Micozkadioglu SD, Erkan AN, Kocer NE. Necrotizing lymph- adenitis of the neck. B-ENT 2009; 5: 51-53.
• Kolodziej-Klek A, Orlowska-Florek R, Galazka K, Gryzwa M. Kikuchi-Fujimoto’s Disease. Pol Arch Med Wewn 2009; 119: 826-829.
• Sagit M, Akın I, Elverici BO, Yurdakul C. An unusual cause of cervical lymphadenopathies. Neth J Med 2008; 66: 262-263.
• Dane F, Öztürk MA, Tecimer T, et al. A case of Kikuchi-Fu- jimoto Disease misdiagnosed as hodgkin’s lymphoma: the importance of second opinion. J BUON 2009; 14: 1-3.
• Mahmood A, Mir R, Salama SR, Miarrostami RM, Lapidus C, Pujol F. Kikuchi’s disease: an unusual presentation and a therapeutic challenge. Yale J Biol Med 2006; 79: 27-33.