BibTex RIS Kaynak Göster

Investigation of intrauterine transmission of Hepatitis B Virus to children from HBsAg-positive pregnant women

Yıl 2011, Cilt: 1 Sayı: 01, 14 - 16, 01.03.2011
https://doi.org/10.5799/ahinjs.02.2011.01.0004

Öz

Objectives: Hepatitis B virus is reported to cause fetal and neonatal hepatitis, with a high rate of vertical transmission. The aim of this study was to determine the rate of vertical transmission during the intrauterine period by determining HBsAg positivity in the cord blood of newborns whose mothers were hepatitis B carriers. Materials and methods: Pregnant women, who were admitted at the Obstetrics and Gynecology Unit for delivery, were included. HBsAg, hepatitis B virus antigen (HBeAg), and antibody against hepatitis B virus antigen (anti-HBe) tests were performed from the pregnant women before delivery. Cord bloods of newborns whose mothers were HBsAg-positive were tested for HBsAg immediately after delivery. HBsAg, HBeAg and anti-HBe tests were conducted. Results: Of the 1,570 pregnant women included in the study, 45 (2.9%) were positive for HBsAg. HBeAg was also found to be positive in 7 (15.6%) of the pregnant women, who were positive for HBsAg, while 38 (84.4%) of HBsAg-positive women were positive for anti-HBe. None of the newborns whose mother was HBsAg-positive was found to be HBsAg-positive. Conclusion: Vertical intrauterine transmission of hepatitis B virus is rare. Screening of all pregnant women for hepatitis B should be recommended in Turkey since the country is of moderate endemicity for HBV seroprevalence. Newborns of HBV positive pregnant women should be vaccinated and hepatitis B immunoglobulin should be given after birth to prevent transmission of hepatitis B.

Kaynakça

  • Harma M, Kafali H, Gungen N, Demir N. Hepatitis B Carrier Status Of Pregnant Women And Vertical Transmission To The Newborn. Perinatal Journal 2003;11(2):29-32.
  • Balik I. Epidemiology of Hepatitis B. In: Kilicturgay K. Viral Hepatitis 94. Istanbul: Nobel Medical Bookstore 1994;91- 101.
  • Hai-Xia Su, et al. High Conservation of Hepatitis B Virus Sur- face Genes during Maternal Vertical Transmission despite Active and Passive Vaccination. Intervirology 2011;54:122- 130.
  • Tasyaran MA. Epidemiology of HBV infection. In: Kilicturgay K, Badur S. Viral Hepatitis 2001. Viral Hepatitis Prevention Society 2001;121-128.
  • Tram T. Tran. Hepatitis B and Pragnancy. Current Hepatitis Reports 2009;8:59-65.
  • Ngui SL, O’Connell S, Elgin RP, et al. Low detection rate and maternal provenance of hepatitis B virüs S gene mutants in cases of failed postnatal immunoprophylaxis in England and Wales. J infect Dis 1997;176:1360-1365.
  • Lee SD, Lo KJ, Tsai YT. Maternal Hepatitis B virus DNA in mother-infant transmission. Lancet 1989;1:719.
  • Karthigesu VD, Allison LM, Ferguson M. A hepatitis B virus variant found in the sera of immunised children induces a conformational change in the HBsAg “a” determinant. J Med Virol 1999;58:346-352.
  • Xu DZ, Yan YP, Choi BC. Risk factors and mechanism of trans- placental transmission of hepatitis B virus: a case-control study. J Med Virol 2002;67:20-26.
  • Kaleli B, Kaleli I, Aktan E, Ozen N, Aksit F. Hbs Ag in Preg- nants And In The Cord Blood Of Their Infants. Perinatal J 1997;5:42-44.
  • Abacı İM, Dusunsel R, Patiroglu T, Cetin N, Kilic H. Hepatitis virus markers in pregnant women and infants and the rela- tionship of tissue antigens. Bull Microbiol 1995;29:170-178.
  • Lin HH, Hsu HY, Hsieh RP, Chen PS, Chen DS. Age spesific prevalence of hepatits B surface and e antigenemia in preg- nant women in Taiwan. Asian Oceania J Obstet Gynecol 1994;20:141-145.
  • Harry TO, Bajani MD, Moses AE. Hepatitis B virus infection among blood donors and pregnant women in Moiduguri, Ni- geira. East Afr Med J 1994;71:596-7.
  • Schweitzer IL. Vertical transmission of the hepatitis B surface antigen. Am J Med Sci 1975;270:287-91.
  • Elefsiniotis IS, Papadakis M, Vlahos G, Daskalakis G, Sa- roglou G, Antsaklis A. Clinical Significance of Hepatitis B surface antigen in cord blood of hepatitis B e-Antigen-nega- tive chronic hepatitis B virus-infected mothers. Intervirology 2009;52:132-134.

Investigation of intrauterine transmission of Hepatitis B Virus to children from HBsAg-positive pregnant women

Yıl 2011, Cilt: 1 Sayı: 01, 14 - 16, 01.03.2011
https://doi.org/10.5799/ahinjs.02.2011.01.0004

Öz

Kaynakça

  • Harma M, Kafali H, Gungen N, Demir N. Hepatitis B Carrier Status Of Pregnant Women And Vertical Transmission To The Newborn. Perinatal Journal 2003;11(2):29-32.
  • Balik I. Epidemiology of Hepatitis B. In: Kilicturgay K. Viral Hepatitis 94. Istanbul: Nobel Medical Bookstore 1994;91- 101.
  • Hai-Xia Su, et al. High Conservation of Hepatitis B Virus Sur- face Genes during Maternal Vertical Transmission despite Active and Passive Vaccination. Intervirology 2011;54:122- 130.
  • Tasyaran MA. Epidemiology of HBV infection. In: Kilicturgay K, Badur S. Viral Hepatitis 2001. Viral Hepatitis Prevention Society 2001;121-128.
  • Tram T. Tran. Hepatitis B and Pragnancy. Current Hepatitis Reports 2009;8:59-65.
  • Ngui SL, O’Connell S, Elgin RP, et al. Low detection rate and maternal provenance of hepatitis B virüs S gene mutants in cases of failed postnatal immunoprophylaxis in England and Wales. J infect Dis 1997;176:1360-1365.
  • Lee SD, Lo KJ, Tsai YT. Maternal Hepatitis B virus DNA in mother-infant transmission. Lancet 1989;1:719.
  • Karthigesu VD, Allison LM, Ferguson M. A hepatitis B virus variant found in the sera of immunised children induces a conformational change in the HBsAg “a” determinant. J Med Virol 1999;58:346-352.
  • Xu DZ, Yan YP, Choi BC. Risk factors and mechanism of trans- placental transmission of hepatitis B virus: a case-control study. J Med Virol 2002;67:20-26.
  • Kaleli B, Kaleli I, Aktan E, Ozen N, Aksit F. Hbs Ag in Preg- nants And In The Cord Blood Of Their Infants. Perinatal J 1997;5:42-44.
  • Abacı İM, Dusunsel R, Patiroglu T, Cetin N, Kilic H. Hepatitis virus markers in pregnant women and infants and the rela- tionship of tissue antigens. Bull Microbiol 1995;29:170-178.
  • Lin HH, Hsu HY, Hsieh RP, Chen PS, Chen DS. Age spesific prevalence of hepatits B surface and e antigenemia in preg- nant women in Taiwan. Asian Oceania J Obstet Gynecol 1994;20:141-145.
  • Harry TO, Bajani MD, Moses AE. Hepatitis B virus infection among blood donors and pregnant women in Moiduguri, Ni- geira. East Afr Med J 1994;71:596-7.
  • Schweitzer IL. Vertical transmission of the hepatitis B surface antigen. Am J Med Sci 1975;270:287-91.
  • Elefsiniotis IS, Papadakis M, Vlahos G, Daskalakis G, Sa- roglou G, Antsaklis A. Clinical Significance of Hepatitis B surface antigen in cord blood of hepatitis B e-Antigen-nega- tive chronic hepatitis B virus-infected mothers. Intervirology 2009;52:132-134.
Toplam 15 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Makaleler
Yazarlar

Özcan Deveci Bu kişi benim

Erkan Yula Bu kişi benim

Turkan Toka Özer Bu kişi benim

Alicem Tekin Bu kişi benim

Bulent Korkut Bu kişi benim

Süleyman Durmaz Bu kişi benim

Süleyman Durmaz Bu kişi benim

Yayımlanma Tarihi 1 Mart 2011
Yayımlandığı Sayı Yıl 2011 Cilt: 1 Sayı: 01

Kaynak Göster

APA Deveci, Ö., Yula, E., Özer, T. T., Tekin, A., vd. (2011). Investigation of intrauterine transmission of Hepatitis B Virus to children from HBsAg-positive pregnant women. Journal of Microbiology and Infectious Diseases, 1(01), 14-16. https://doi.org/10.5799/ahinjs.02.2011.01.0004
AMA Deveci Ö, Yula E, Özer TT, Tekin A, Korkut B, Durmaz S, Durmaz S. Investigation of intrauterine transmission of Hepatitis B Virus to children from HBsAg-positive pregnant women. J Microbil Infect Dis. Mart 2011;1(01):14-16. doi:10.5799/ahinjs.02.2011.01.0004
Chicago Deveci, Özcan, Erkan Yula, Turkan Toka Özer, Alicem Tekin, Bulent Korkut, Süleyman Durmaz, ve Süleyman Durmaz. “Investigation of Intrauterine Transmission of Hepatitis B Virus to Children from HBsAg-Positive Pregnant Women”. Journal of Microbiology and Infectious Diseases 1, sy. 01 (Mart 2011): 14-16. https://doi.org/10.5799/ahinjs.02.2011.01.0004.
EndNote Deveci Ö, Yula E, Özer TT, Tekin A, Korkut B, Durmaz S, Durmaz S (01 Mart 2011) Investigation of intrauterine transmission of Hepatitis B Virus to children from HBsAg-positive pregnant women. Journal of Microbiology and Infectious Diseases 1 01 14–16.
IEEE Ö. Deveci, “Investigation of intrauterine transmission of Hepatitis B Virus to children from HBsAg-positive pregnant women”, J Microbil Infect Dis, c. 1, sy. 01, ss. 14–16, 2011, doi: 10.5799/ahinjs.02.2011.01.0004.
ISNAD Deveci, Özcan vd. “Investigation of Intrauterine Transmission of Hepatitis B Virus to Children from HBsAg-Positive Pregnant Women”. Journal of Microbiology and Infectious Diseases 1/01 (Mart 2011), 14-16. https://doi.org/10.5799/ahinjs.02.2011.01.0004.
JAMA Deveci Ö, Yula E, Özer TT, Tekin A, Korkut B, Durmaz S, Durmaz S. Investigation of intrauterine transmission of Hepatitis B Virus to children from HBsAg-positive pregnant women. J Microbil Infect Dis. 2011;1:14–16.
MLA Deveci, Özcan vd. “Investigation of Intrauterine Transmission of Hepatitis B Virus to Children from HBsAg-Positive Pregnant Women”. Journal of Microbiology and Infectious Diseases, c. 1, sy. 01, 2011, ss. 14-16, doi:10.5799/ahinjs.02.2011.01.0004.
Vancouver Deveci Ö, Yula E, Özer TT, Tekin A, Korkut B, Durmaz S, Durmaz S. Investigation of intrauterine transmission of Hepatitis B Virus to children from HBsAg-positive pregnant women. J Microbil Infect Dis. 2011;1(01):14-6.