Difenhidramin HCl'nin Yüklenmesi ve Salımı için Diyatomit-Kitosan Kompozitlerinin Hazırlanması

Yıl 2023, Cilt: 4 Sayı: 2, 542 - 560, 26.12.2023

Zeynep Özkan , Muhammet Davut Arpa , Melih Özçatal , Hakan Çiftçi

https://doi.org/10.55546/jmm.1326482

Öz

Diyatomit cevherleri, doğada bol miktarda bulunmaları, biyouyumlulukları ve yüksek yüzey alanları nedeniyle adsorban ve ilaç taşıyıcı sistem olarak büyük potansiyele sahiptir. Bu çalışmanın ilk aşamasında ham diatomit cevheri öğütme ve kalsinasyon işlemleri ile zenginleştirilmiştir. Ham diyatomit için yüzey alanı 21.7 m2/g iken zenginleştirme sonrası kalsine diyatomit için 75.1 m2/g olarak bulunmuştur. Daha sonra, farklı bileşim oranlarına sahip bir dizi diatomit-kitosan kompoziti üretilmiştir. Antihistaminik ajan olan difenhidramin hidroklorürün (DPH) hazırlanan kompozitler üzerindeki yükleme (adsorpsiyon) performansları incelenmiştir. Hazırlanan DPH yüklü formülasyonlarda en yüksek yükleme kapasitesi 91.1 mg/g, en düşük yükleme kapasitesi 48.8 mg/g olmuştur. DPH yükleme çalışmalarından sonra DPH salım profilleri (desorpsiyon) ve kompozitlerden salım kinetikleri incelenmiştir. In vitro salım çalışmaları sonucunda kitosan polimeri içeren formülasyonların kitosan içermeyen formülasyonlara göre daha yavaş salım gösterdiği gözlemlenmiştir. Formülasyonların %70-90 aralığında kümülatif DPH salıma sahip olduğu ve salımın 45-90 dakika arasında tamamlandığı belirlenmiştir. Hazırlanan formülasyonların in vitro salım profilleri Higuchi kinetiği ile uyumlu olduğu belirlenmiştir.

Anahtar Kelimeler

Diyatomit, Kitosan, Difenhidramin

Proje Numarası

23.FEN.BIL.05

Teşekkür

This study was financially supported by Afyon Kocatepe University, Scientific Research Project (BAP), Project No: 23.FEN.BIL.05.

Preparation of Diatomite-Chitosan Composites for Loading and Release of Diphenhydramine HCl

Öz

Diatomite ores have great potential as an adsorbent and drug carrier system due to their natural abundance, biocompatible, and high surface area. In the first stage of this study, raw diatomite ore was enriched by grinding and calcination processes. As a result of the enrichment process, the surface area was found to be 21.7 m2/g for raw diatomite and 75.1 m2/g for calcined diatomite. Subsequently, a series of diatomite-chitosan composites with different composition ratios were produced. Then, the loading (adsorption) performances of diphenhydramine hydrochloride (DPH), an antihistaminic agent, were investigated on the prepared composites. The highest loading capacity was 91.1 mg/g, and the lowest loading capacity was 48.8 mg/g in the prepared DPH-loaded formulations. After DPH loading studies, DPH release profiles (desorption) and release kinetics from composites were investigated. As a result of in vitro release studies, it was observed that formulations containing chitosan polymer had slower release than chitosan free formulations. It was determined that the formulations had a cumulative release in the 70-90% range, and the release processes were completed between 45-90 minutes. In vitro release profiles of the prepared formulations were compatible with Higuchi kinetics.

Anahtar Kelimeler

Diatomite, Chitosan, Diphenhydramine, Release kinetic.

Destekleyen Kurum

Afyon Kocatepe University

Proje Numarası

23.FEN.BIL.05

Teşekkür

This study was financially supported by Afyon Kocatepe University, Scientific Research Project (BAP), Project No: 23.FEN.BIL.05.

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