KADIN VE ERKEK BEYİNLERİ ARASINDAKİ YAPISAL, İŞLEVSEL VE BİLİŞSEL FARKLILIKLAR: NÖROBİLİMSEL BİR DERLEME

Yıl 2025, Cilt: 12 Sayı: 3, 94 - 97, 31.12.2025

Sibel Yamaç Tamkafa , Rıdvan Ekmekçi

https://doi.org/10.32739/jnbs.12.3.280

Öz

Bu derleme çalışması, kadın ve erkek beyinleri arasındaki yapısal, işlevsel ve bilişsel farklılıkları nörobilimsel bulgular doğrultusunda sistematik olarak incelemeyi amaçlamaktadır. Cinsiyet farklılaşması süreci, prenatal dönemde hormonal etkilerle başlamaktadır ve bu süreç, postnatal çevresel uyaranlarla şekillenmeye devam etmektedir. Literatür taramasına dayanan bu derlemede, nöroanatomik yapılar (örneğin korpus kallozum, hipokampus, amigdalalar), nöral iletişim örüntüleri ve bilişsel performans farklılıkları ele alınmıştır. Ayrıca, hormonların nörogelişimsel süreçler üzerindeki etkileri ve cinsiyet temelli bilişsel avantajların bireysel farklılıklarla ilişkisi tartışılmıştır. Bulgular, cinsiyetler arası farkların üstünlük değil, işlevsel tamamlayıcılık ve nöroçeşitlilik bağlamında değerlendirilmesi gerektiğini göstermektedir.

STRUCTURAL, FUNCTIONAL, AND COGNITIVE DIFFERENCES BETWEEN FEMALE AND MALE BRAINS: A NEUROSCIENTIFIC REVIEW

Öz

This review aims to systematically examine the structural, functional, and cognitive differences between male and female brains through neuroscientific findings. The process of sexual differentiation begins prenatally under hormonal influences and continues to be shaped by environmental stimuli after birth. Based on an extensive literature review, the study discusses neuroanatomical structures (e.g., corpus callosum, hippocampus, amygdalae), neural connectivity patterns, and cognitive performance variations. It also explores the influence of hormones on neurodevelopmental processes and the relationship between sex-based cognitive tendencies and individual differences. The findings indicate that gender-based distinctions should be interpreted within the framework of functional complementarity and neurodiversity, rather than superiority.

Anahtar Kelimeler

Sex Differences , Neuroscience , Brain Structure , Hormonal Influence , Cognitive Performance

Kaynakça

• 1. Benbow CP, Lubinski D, Shea DL, Eftekhari-Sanjani H. Sex differences in mathematical reasoning ability at age 13: Their status 20 years later. Psychol Sci. 2000;11(6):474–480. https://doi.org/10.1111/1467-9280.00291
• 2. Bleier R, Byne W, Siggelkow I. Cytoarchitectonic sexual dimorphisms of the medial preoptic and anterior hypothalamic areas in guinea pig, rat, hamster, and mouse. J Comp Neurol. 1982;212(2):118–130.https://doi.org/10.1002/cne.902120203
• 3. Brizendine L. The Female Brain (T. Yılmaz, Trans.). Say Yayınları. (Original work published 2006)
• 4. Cahill L. Why sex matters for neuroscience. Nat Rev Neurosci.2006;7(6):477–484. https://doi.org/10.1038/nrn1909
• 5. Cosgrove KP, Mazure CM, Staley JK. Evolving knowledge of sex differences in brain structure, function, and chemistry. Biol Psychiatry. 2007;62(8):847–855. https://doi.org/10.1016/j.biopsych.2007.03.001
• 6. Diamond MC, Dowling GA, Johnson RE. Morphologic cerebral cortical asymmetry in male and female rats. Exp Neurol. 1981;71(2):261–268. https://doi.org/10.1016/0014-4886(81)90029-0
• 7. Eliot L. Pink Brain, Blue Brain: How Small Differences Grow into Troublesome Gaps—and What We Can Do About It. Mariner Books; 2011.
• 8. Fine C. Delusions of Gender: How Our Minds, Society, and Neurosexism Create Difference. W. W. Norton & Company; 2013.
• 9. Fitch RH, Berrebi AS, Cowell PE, Schrott LM, Denenberg VH. Corpus callosum: Effects of neonatal hormones on sexual dimorphism in the rat. Brain Res. 1990;515(1–2):111–116. https://doi.org/10.1016/0006-8993(90)90566-C
• 10. Greenough WT, Carter CS, Steerman C, DeVoogd TJ. Sex differences in dendritic patterns in hamster preoptic area. Brain Res. 1977;126: 63–72. https://doi.org/10.1016/0006-8993(77)90861-4
• 11. Herlitz A, Airaksinen E, Nordström E. Sex differences in episodic memory: The impact of verbal and visuospatial ability. Neuropsychology. 1999;13(4):590–597. https://doi.org/10.1037/0894-4105.13.4.590
• 12. Henrich J, Heine SJ, Norenzayan A. The weirdest people in the world? Behav Brain Sci. 2010;33(2–3):61–83. https://doi.org/10.1017/S0140525X0999152X
• 13. Hines M. Prenatal testosterone and gender-related behaviour. Eur J Endocrinol. 2006;155(Suppl 1):S115–S121. https://doi.org/10.1530/eje.1.02272
• 14. Hyde JS. The gender similarities hypothesis. Am Psychol. 2005;60(6):581–592. https://doi.org/10.1037/0003-066X.60.6.581
• 15. Ingalhalikar M, Smith A, Parker D, et al. Sex differences in the structural connectome of the human brain. Proc Natl Acad Sci USA. 2014;111(2): 823–828. https://doi.org/10.1073/pnas.1316909110
• 16. Kimura D. Sex, sexual orientation, and sex hormones influence human cognitive function. Curr Opin Neurobiol. 1996;6(2):259–263. https://doi.org/10.1016/S0959-4388(96)80077-0
• 17. Luders E, Narr KL, Thompson PM, et al. Gender effects on cortical thickness and the influence of scaling. Hum Brain Mapp. 2009;30(7): 2197–2205. https://doi.org/10.1002/hbm.20674
• 18. Joel D, Berman Z, Tavor I, et al. Sex beyond the genitalia: The human brain mosaic. Proc Natl Acad Sci USA. 2015;112(50):15468–15473. https://doi.org/10.1073/pnas.1509654112
• 19. Matsumoto A, Arai Y. Male-female difference in synaptic organization of the ventromedial nucleus of the hypothalamus in the rat. Neuroendocrinology. 1986;42(3):232–236. https://doi.org/10.1159/000124419
• 20. McEwen BS, Milner TA. Understanding the broad influence of sex hormones and sex differences in the brain. J Neurosci Res. 2017;95 (1-2):24–39. https://doi.org/10.1002/jnr.23857
• 21. Ngun TC, Ghahramani N, Sánchez FJ, Bocklandt S, Vilain E. The genetics of sex differences in brain and behavior. Nat Neurosci. 2010;13(10):1022–1028. https://doi.org/10.1038/nn.2615
• 22. Pakkenberg B, Gundersen HJ. Neocortical neuron number in humans: Effect of sex and age. J Comp Neurol. 1997;384(2):312–320. https://doi.org/10.1002/(SICI)1096-9861(19970728)384:2<312::AID-CNE10>3.0.CO;2-Z
• 23. Rippon G. The Gendered Brain: The New Neuroscience That Shatters the Myth of the Female Brain. Bodley Head; 2019.
• 24. McCarthy MM, Arnold AP. Reframing sexual differentiation of the brain. Nat Neurosci. 2011;14(6):677–683. https://doi.org/10.1038/nn.2834
• 25. Ruigrok ANV, Salimi-Khorshidi G, Lai MC, et al. A meta-analysis of sex differences in human brain structure. Neurosci Biobehav Rev. 2014;39:34–50. https://doi.org/10.1016/j.neubiorev.2013.12.004
• 26. Savic I, Frisen L, Manzouri A. Role of testosterone and Y chromosome genes for the masculinization of the human brain. Hum Brain Mapp. 2017;38(4):1801–1814. https://doi.org/10.1002/hbm.23486
• 27. Seymour B, Dolan R. Emotion, decision making, and the amygdala. Neuron. 2008;58(5):662–671. https://doi.org/10.1016/j.neuron.2008.05.009
• 28. Swaab DF, Garcia-Falgueras A. Sexual hormones and the brain: An essential alliance for sexual identity and sexual orientation. Endocr Dev. 2010;17:22–35. https://doi.org/10.1159/000262525
• 29. Verma R, Howard D, Husain M, Banerjee A, Kesler SR. Neural correlates of sex differences in cognitive decline. Neuroimage Clin. 2013;3:113–122. https://doi.org/10.1016/j.nicl.2013.07.010
• 30. Voyer D, Voyer S, Bryden MP. Magnitude of sex differences in spatial abilities: A meta-analysis and consideration of critical variables. Psychol Bull. 1995;117(2):250–270. https://doi.org/10.1037/0033 -2909.117.2.250
• 31. Witelson SF, Glezer II, Kigar DL. Women have greater density of neurons in posterior temporal cortex. J Neurosci. 1995;15(5):3418–3428. https://doi.org/10.1523/JNEUROSCI.15-05-03418.1995