Comparison of HOMA-IR Values in Covid-19 Negative and Positive Patients

Öz

Objective: This study compared the HOMA-IR values of COVID-19 patients with COVID-19-negative patients. Method: A total of 2116 COVID-19 + patients, 1186 men and 850 women, and 1127 COVID-19 - patients, 313 men and 814 women, were included in the study. The study was conducted on patients with definite COVID-19 + and - between June 1, 2020 and July 31, 2020. The patients' data were obtained retrospectively from the hospital information management system. The diagnosis of COVID-19 in the included patients was made by a real-time polymerase chain reaction and computed tomography lung scanning. The relationship between the HOMA IR values of COVID-19 + and - patients was compared. Results: The HOMA IR value of patients who were positive without gender discrimination was found to be significantly higher in patients with COVİD-19 + patients. No significant gender differences were detected in HOMA IR values in COVİD-19 + patients. The HOMA IR values of men were found to be significantly higher in patients with COVID-19 – patients in differences according to gender. A positive correlation was found between age and HOMA IR in COVID-19 patients. No significant relationship was found between age and HOMA IR in COVİD-19 + patients. Conclusion: It was determined that there was no significant difference in HOMA-IR values in COVID-19 + patients according to gender, and the HOMA-IR values of patients with COVID-19 + were found to be significantly higher without gender discrimination.

Anahtar Kelimeler

• COVID-19
• HOMA IR
• hospital information management system

Kaynakça

1. Bakris GL. (1995). Pathogenesis of hypertension in diabetes. Diabetes Reviews, 3:460-76.
2. Beşirbellioğlu BA. (2007). SARS kuşkulu ve damlacık çekirdeği ile bulaşan infeksiyonlarda DAS yönetimi. 5. Ulusal Sterilizasyon Dezenfeksiyon Kongresi. 4-8 Nisan 2007. 502-504. 8.
3. Brufsky A. (2020). Hyperglycemia, hydroxychloroquine, and the COVID- 19 pandemic. J. Med. Virol, 92(7):770–775.
4. Cascella M, Rajnik M, Aleem A, Dulebohn SC, Di Napoli R. (2023). Features, Evaluation, and Treatment of Coronavirus (COVID-19). 2023 Jan 9. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 32150360.
5. Çelik D, Köse Ş. (2020). Erişkinlerde COVID-19: Klinik bulgular. Tepecik Eğit. ve Araşt. Hast. Dergisi, 30 (Ek sayı):43-48.
6. De Fronzo RA, Goldberg M, Agus ZS. (1976). The effects of glucose and insulin on renal electrolyte transport. J Clin Invest., 58(1):83-90. https://doi.org/10.1172/JCI108463
7. Despres JP, Lamarche B, Mauriege P, et al. (1996). Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med, 334(15):952-7. https://doi.org/10.1056/ NEJM199604113341504
8. Fu L, Wang B, Yuan T. (2020). Clinical characteristics of coronavirus disease 2019 (COVID 19) In China: A systematic review and meta-analysis. J Infect, 80(6):656-665. doi:10.1016/j.jinf.2020.03.041

9. Guo W, Li M, Dong Y, et al. (2020). Diabetes is a risk factor for theprogression and prognosis of COVID-19. Diabetes Metab Res Rev, 31;36(7):e3319. doi: 10.1002/dmrr.3319.
10. Gupta R, Ghosh A, Singh AK, Misra A. (2020). Clinical considerations for diabetes in times of COVID-19 epidemic. Diabetes Metab Syndr, 14(3):211-212. doi: 10.1016/j.dsx.2020.03.002.
11. Hill MA, Mantzoros C, Sowers JR. (2020). Commentary: COVID-19 in patients with diabetes. Metabolism, 107:154217. doi: 10.1016/j.metabol.2020.154217.
12. Kutlutürk F. (2020). COVID-19 Pandemisi ve Diabetes Mellitus. Türk Diyab Obez, 2:130-137.
13. Sheu WH, Jeng CY, Young MS, et al. (2000). Coronary artery disease risk predicted by insulin resistance, plasma lipids, and hypertension in people without diabetes. Am J Med Sci, 319(2):84-8. https://doi.org/10.1097/00000441- 200002000-00003
14. Reaven GM. (1988). Role of insulin resistance in human disease. Diabetes, 37:1595-607. https://doi.org/10.2337/diab.37.12.1595.
15. Scott M, Grundy MD, James I, et al.(2005). Diagnosis and management of the metabolic syndrome. Circulation, 112(17):2735-52.
16. Soliman AT, Al-Amri M, Alleethy K, Alaaraj N, Hamed N, De Sanctis V. (2020). Newly-onset type 1 diabetes mellitus precipitated by COVID- 19 in an 8-month-old infant. Acta Biomed, 91(3):ahead of print. doi: 10.23750/abm.v91i3.10074.
17. Yazar H, Kayacan Y, Özdin M. (2021). Investigation of C-reactive Protein and D-dimer Findings in Patients with COVID-19. Bezmialem Science, 9(Supplement 1):4-8.
18. Zhu L, She ZG, Cheng X, Qin JJ, Zhang XJ, Cai J, et al. (2020). Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes. Cell Metab, 31(6):1068-1077.