Sistematik Derlemeler ve Meta Analiz
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Bağırsak Mikrobiotası, İnsulin Direnci ve Diyabet İlişkisi

Yıl 2022, Cilt: 4 Sayı: 2, 31 - 39, 31.12.2022

Ayşe Betül Cingöz

Öz

ÖZET
Amaç: Bu çalışmada bağırsak mikrobiyotası insulin direnci ve diyabet arasındaki ilişki araştırılmıştır. Son yıllarda bağırsak mikrobiyotası, insulin direnci ve diyabet ilişkisi ile ilgili yapılan çalışmalar incelenmiştir. Bağırsak mikrobiyotası diyabet ilişkisinin altında yatan potansiyel mekanizmalar hakkında verilmiş ve bu ilişkiye dayanarak diyabeti ve insulin direncini önlemede kullanılabilecek yöntemler araştırılmıştır.
Yöntemler: Pubmed ve Google Scholar gibi veri tabanları kullanılarak son yıllarda bağırsak mikrobiyotası, insulin direnci ve diyabet ile ilgili yapılan çalışmalar incelenmiş ve derleme halinde sunulmuştur.
Bulgular: Diyabet dünya çapında milyonlarca insanı etkileyen kronik metabolik bir hastalıktır. Diyabetin nedenleri, etkileri, önleme stratejileri sürekli araştırılmaktadır. Yapılan çalışmalar araştırmacılara yeni bakış açıları kazandırmaktadır. İnsulin direnci veya diyabeti olan hastalarda bağırsak mikrobiyotasında sağlıklı insanlara göre değişiklikler olduğu gözlenmiştir. Bağırsak mikrobiyota çeşitliliği ile insulin direnci ve diyabet arasında dikkate değer bir ilişki mevcuttur ve kısa zincirli yağ asitleri bu ilişkide önemli bir rol üstlenmektedir.
Sonuç: Bağırsak mikrobiyotasının çeşitliliği diyabet ve insulin direncini önlemede önemli bir strateji olabilir. Mikrobiyotanın olumlu yönde değiştirilmesi (prebiyotik ve probiyotik tüketimi, fekal mikrobiyom transferi vb.) obezite, insulin direnci ve diyabeti önleme veya tedavi yöntemlerinden biri olabilir. Bağırsak mikrobiyotası ile diyabet ilişkisini ve mikrobiyotanın terapötik potansiyelini anlamak için daha fazla araştırmaya ihtiyaç vardır.
Anahtar kelimeler: bağırsak mikrobiyotası, diyabet, insulin direnci, prebiyotik probiyotik, kısa zincirli yağ asitleri

Anahtar Kelimeler

bağırsak mikrobiyotası diyabet insulin direnci prebiyotik probiyotik kısa zincirli yağ asitleri bağırsak mikrobiyotası, diyabet, insulin direnci, prebiyotik probiyotik, kısa zincirli yağ asitleri gut microbiota diabetes insulin resistance prebiotic probiotic short chain fatty acids

Kaynakça

  • Bellikci Koyu, E., & Büyüktuncer Demirel, Z. (2018). Fonksiyonel Bir Besin: Kefir. Journal of Nutrition and Dietetics, 46(2), 166–175. https://doi.org/10.33076/2018.bdd.301
  • Chen, Z., Radjabzadeh, D., Chen, L., Kurilshikov, A., Kavousi, M., Ahmadizar, F., Ikram, M. A., Uitterlinden, A. G., Zhernakova, A., Fu, J., Kraaij, R., & Voortman, T. (2021). Association of Insulin Resistance and Type 2 Diabetes with Gut Microbial Diversity: A Microbiome-Wide Analysis from Population Studies. JAMA Network Open, 4(7). https://doi.org/10.1001/jamanetworkopen.2021.18811
  • Hou, K., Wu, Z. X., Chen, X. Y., Wang, J. Q., Zhang, D., Xiao, C., Zhu, D., Koya, J. B., Wei, L., Li, J., & Chen, Z. S. (2022). Microbiota in health and diseases. In Signal transduction and targeted therapy (Vol. 7, Issue 1, p. 135). NLM (Medline). https://doi.org/10.1038/s41392-022-00974-4
  • International Diabetes Federation (IDF). “Diabetes Atlas 10th edition.” 08.12.2022. www.diabetesatlas.org International Diabetes Federation (IDF). “Turkey-diabetes-report.” 08.12.2022.https://diabetesatlas.org/data/en/country/203/tr.html
  • Kayacan Y, Kola AZ, Guandalini S, Yazar H, Söğüt MÜ. (2022). The Use of Probiotics Combined with Exercise Affects Thiol/Disulfide Homeostasis, an Oxidative Stress Parameter. Nutrients. 2022 Aug 29;14(17):3555. doi: 10.3390/nu14173555. PMID: 36079815; PMCID: PMC9460532.
  • Kim, C. H. (2018). Microbiota or short-chain fatty acids: Which regulates diabetes? Cellular and Molecular Immunology, 15(2), 88–91. https://doi.org/10.1038/cmi.2017.57 Kılıç Ü, Altındiş M. (2017). Antibiyotik Kullanımı ve Mikrobiyota: J Biotechnol and Strategic Health Res (Special issue):39-43
  • Kumar, A., Arora, A., Sharma, P., Anikhindi, S. A., Bansal, N., Singla, V., Khare, S., & Srivastava, A. (2020). Is diabetes mellitus associated with mortality and severity of COVID-19? A meta-analysis. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 14(4), 535–545. https://doi.org/10.1016/j.dsx.2020.04.044
  • Lange, K., Buerger, M., Stallmach, A., & Bruns, T. (2016). Effects of Antibiotics on Gut Microbiota. In Digestive Diseases (Vol. 34, Issue 3, pp. 260–268). S. Karger AG. https://doi.org/10.1159/000443360
  • Leong, K. S. W., Jayasinghe, T. N., Wilson, B. C., Derraik, J. G. B., Albert, B. B., Chiavaroli, V., Svirskis, D. M., Beck, K. L., Conlon, C. A., Jiang, Y., Schierding, W., Vatanen, T., Holland, D. J., O’Sullivan, J. M., & Cutfield, W. S. (2020). Effects of Fecal Microbiome Transfer in Adolescents With Obesity: The Gut Bugs Randomized Controlled Trial. JAMA Network Open, 3(12), e2030415. https://doi.org/10.1001/jamanetworkopen.2020.30415
  • Morrison, D. J., & Preston, T. (2016). Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. In Gut Microbes (Vol. 7, Issue 3, pp. 189–200). Taylor and Francis Inc. https://doi.org/10.1080/19490976.2015.1134082
  • Mueller, N. T., Differding, M. K., Zhang, M., Maruthur, N. M., Juraschek, S. P., Miller, E. R., Appel, L. J., & Yeh, H. C. (2021). Metformin affects gut microbiome composition and function and circulating short-chain fatty acids: A randomized trial. Diabetes Care, 44(7), 1462–1471. https://doi.org/10.2337/dc20-2257
  • Sağlık Bakanlığı. “2020 Sağlık İstatistikleri Yıllığı” syf. 194. https://www.saglik.gov.tr/TR,89801/saglik-istatistikleri-yilligi-2020-yayinlanmistir.html erişim 08.12.2022
  • Sanna, S., van Zuydam, N. R., Mahajan, A., Kurilshikov, A., Vich Vila, A., Võsa, U., Mujagic, Z., Masclee, A. A. M., Jonkers, D. M. A. E., Oosting, M., Joosten, L. A. B., Netea, M. G., Franke, L., Zhernakova, A., Fu, J., Wijmenga, C., & McCarthy, M. I. (2019). Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases. In Nature Genetics (Vol. 51, Issue 4, pp. 600–605). Nature Publishing Group. https://doi.org/10.1038/s41588-019-0350-x
  • Sender, R., Fuchs, S., & Milo, R. (2016). Revised Estimates for the Number of Human and Bacteria Cells in the Body. PLoS Biology, 14(8). https://doi.org/10.1371/journal.pbio.1002533
  • Tao, Y. W., Gu, Y. L., Mao, X. Q., Zhang, L., & Pei, Y. F. (2020). Effects of probiotics on type II diabetes mellitus: A meta-analysis. In Journal of Translational Medicine (Vol. 18, Issue 1). BioMed Central. https://doi.org/10.1186/s12967-020-02213-2
  • Wang, H., Lu, Y., Yan, Y., Tian, S., Zheng, D., Leng, D., Wang, C., Jiao, J., Wang, Z., & Bai, Y. (2020). Promising Treatment for Type 2 Diabetes: Fecal Microbiota Transplantation Reverses Insulin Resistance and Impaired Islets. Frontiers in Cellular and Infection Microbiology, 9. https://doi.org/10.3389/fcimb.2019.00455
  • Wang, B., Zhang, L., Wang, Y., Dai, T., Qin, Z., Zhou, F., & Zhang, L. (2022). Alterations in microbiota of patients with COVID-19: potential mechanisms and therapeutic interventions. In Signal Transduction and Targeted Therapy (Vol. 7, Issue 1). Springer Nature. https://doi.org/10.1038/s41392-022-00986-0
  • World Health Organization (WHO). 08.12.2022. https://www.who.int/health-topics/diabetes#tab=tab_1
  • Wu, H., Tremaroli, V., Schmidt, C., Lundqvist, A., Olsson, L. M., Krämer, M., Gummesson, A., Perkins, R., Bergström, G., & Bäckhed, F. (2020). The Gut Microbiota in Prediabetes and Diabetes: A Population-Based Cross-Sectional Study. Cell Metabolism, 32(3), 379-390.e3. https://doi.org/10.1016/j.cmet.2020.06.011
  • Quigley, E. M. M. (2019). Prebiotics and Probiotics in Digestive Health. In Clinical Gastroenterology and Hepatology (Vol. 17, Issue 2, pp. 333–344). W.B. Saunders. https://doi.org/10.1016/j.cgh.2018.09.028
  • Yeoh, Y. K., Zuo, T., Lui, G. C. Y., Zhang, F., Liu, Q., Li, A. Y. L., Chung, A. C. K., Cheung, C. P., Tso, E. Y. K., Fung, K. S. C., Chan, V., Ling, L., Joynt, G., Hui, D. S. C., Chow, K. M., Ng, S. S. S., Li, T. C. M., Ng, R. W. Y., Yip, T. C. F., … Ng, S. C. (2021). Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19. Gut, 70(4), 698–706. https://doi.org/10.1136/gutjnl-2020-323020
  • Zhao, L., Zhang, F., Ding, X., Wu, G., Lam, Y. Y., Wang, X., Fu, H., Xue, X., Lu, C., Ma, J., Yu, L., Xu, C., Ren, Z., Xu, Y., Xu, S., Shen, H., Zhu, X., Shi, Y., Shen, Q., … Zhang, † Chenhong. (2018). Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes. http://science.sciencemag.org/

GUT MICROBIOTA AND INSULIN RESISTANCE,DIABETES

Yıl 2022, Cilt: 4 Sayı: 2, 31 - 39, 31.12.2022

Ayşe Betül Cingöz

Öz

ABSTRACT
Objective: In this study, the association of intestinal microbiota with insulin resistance and diabetes was investigated. Recent studies have examined the association of intestinal microbiota with insulin resistance, and diabetes. The potential mechanisms underlying this association were discussed, and methods for preventing diabetes and insulin resistance were investigated based on this association.
Methods: Using databases such as Pubmed and Google Scholar, studies on gut microbiota, insulin resistance and diabetes in recent years have been reviewed and presented in a review.
Results: Diabetes is a chronic metabolic disease that affects millions of people worldwide. The causes, effects, and prevention strategies of diabetes are constantly being researched. The research conducted provides researchers with new aspects. It has been observed that there are changes in the gut microbiota in patients with insulin resistance or diabetes compared to healthy people. There is a remarkable association between intestinal microbiota diversity and insulin resistance; short-chain fatty acids also play an important role in this relationship.
Conclusion: The diversity of the gut microbiota could be an important preventive strategy for diabetes and insulin resistance. Modification of microbiota (prebiotic and probiotic consumption, fecal microbiome transfer, etc.) can be used to prevent or treat insulin resistance, obesity, and diabetes. The relationship between the gut microbiota and diabetes, as well as the microbiota's therapeutic potential, both require further investigation.
Keywords: gut microbiota, diabetes, insulin resistance, prebiotic probiotic, short chain fatty acids

Anahtar Kelimeler

gut microbiota diabetes insulin resistance prebiotic probiotic short chain fatty acids gut microbiota, diabetes, insulin resistance, prebiotic probiotic, short chain fatty acids

Kaynakça

  • Bellikci Koyu, E., & Büyüktuncer Demirel, Z. (2018). Fonksiyonel Bir Besin: Kefir. Journal of Nutrition and Dietetics, 46(2), 166–175. https://doi.org/10.33076/2018.bdd.301
  • Chen, Z., Radjabzadeh, D., Chen, L., Kurilshikov, A., Kavousi, M., Ahmadizar, F., Ikram, M. A., Uitterlinden, A. G., Zhernakova, A., Fu, J., Kraaij, R., & Voortman, T. (2021). Association of Insulin Resistance and Type 2 Diabetes with Gut Microbial Diversity: A Microbiome-Wide Analysis from Population Studies. JAMA Network Open, 4(7). https://doi.org/10.1001/jamanetworkopen.2021.18811
  • Hou, K., Wu, Z. X., Chen, X. Y., Wang, J. Q., Zhang, D., Xiao, C., Zhu, D., Koya, J. B., Wei, L., Li, J., & Chen, Z. S. (2022). Microbiota in health and diseases. In Signal transduction and targeted therapy (Vol. 7, Issue 1, p. 135). NLM (Medline). https://doi.org/10.1038/s41392-022-00974-4
  • International Diabetes Federation (IDF). “Diabetes Atlas 10th edition.” 08.12.2022. www.diabetesatlas.org International Diabetes Federation (IDF). “Turkey-diabetes-report.” 08.12.2022.https://diabetesatlas.org/data/en/country/203/tr.html
  • Kayacan Y, Kola AZ, Guandalini S, Yazar H, Söğüt MÜ. (2022). The Use of Probiotics Combined with Exercise Affects Thiol/Disulfide Homeostasis, an Oxidative Stress Parameter. Nutrients. 2022 Aug 29;14(17):3555. doi: 10.3390/nu14173555. PMID: 36079815; PMCID: PMC9460532.
  • Kim, C. H. (2018). Microbiota or short-chain fatty acids: Which regulates diabetes? Cellular and Molecular Immunology, 15(2), 88–91. https://doi.org/10.1038/cmi.2017.57 Kılıç Ü, Altındiş M. (2017). Antibiyotik Kullanımı ve Mikrobiyota: J Biotechnol and Strategic Health Res (Special issue):39-43
  • Kumar, A., Arora, A., Sharma, P., Anikhindi, S. A., Bansal, N., Singla, V., Khare, S., & Srivastava, A. (2020). Is diabetes mellitus associated with mortality and severity of COVID-19? A meta-analysis. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 14(4), 535–545. https://doi.org/10.1016/j.dsx.2020.04.044
  • Lange, K., Buerger, M., Stallmach, A., & Bruns, T. (2016). Effects of Antibiotics on Gut Microbiota. In Digestive Diseases (Vol. 34, Issue 3, pp. 260–268). S. Karger AG. https://doi.org/10.1159/000443360
  • Leong, K. S. W., Jayasinghe, T. N., Wilson, B. C., Derraik, J. G. B., Albert, B. B., Chiavaroli, V., Svirskis, D. M., Beck, K. L., Conlon, C. A., Jiang, Y., Schierding, W., Vatanen, T., Holland, D. J., O’Sullivan, J. M., & Cutfield, W. S. (2020). Effects of Fecal Microbiome Transfer in Adolescents With Obesity: The Gut Bugs Randomized Controlled Trial. JAMA Network Open, 3(12), e2030415. https://doi.org/10.1001/jamanetworkopen.2020.30415
  • Morrison, D. J., & Preston, T. (2016). Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. In Gut Microbes (Vol. 7, Issue 3, pp. 189–200). Taylor and Francis Inc. https://doi.org/10.1080/19490976.2015.1134082
  • Mueller, N. T., Differding, M. K., Zhang, M., Maruthur, N. M., Juraschek, S. P., Miller, E. R., Appel, L. J., & Yeh, H. C. (2021). Metformin affects gut microbiome composition and function and circulating short-chain fatty acids: A randomized trial. Diabetes Care, 44(7), 1462–1471. https://doi.org/10.2337/dc20-2257
  • Sağlık Bakanlığı. “2020 Sağlık İstatistikleri Yıllığı” syf. 194. https://www.saglik.gov.tr/TR,89801/saglik-istatistikleri-yilligi-2020-yayinlanmistir.html erişim 08.12.2022
  • Sanna, S., van Zuydam, N. R., Mahajan, A., Kurilshikov, A., Vich Vila, A., Võsa, U., Mujagic, Z., Masclee, A. A. M., Jonkers, D. M. A. E., Oosting, M., Joosten, L. A. B., Netea, M. G., Franke, L., Zhernakova, A., Fu, J., Wijmenga, C., & McCarthy, M. I. (2019). Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases. In Nature Genetics (Vol. 51, Issue 4, pp. 600–605). Nature Publishing Group. https://doi.org/10.1038/s41588-019-0350-x
  • Sender, R., Fuchs, S., & Milo, R. (2016). Revised Estimates for the Number of Human and Bacteria Cells in the Body. PLoS Biology, 14(8). https://doi.org/10.1371/journal.pbio.1002533
  • Tao, Y. W., Gu, Y. L., Mao, X. Q., Zhang, L., & Pei, Y. F. (2020). Effects of probiotics on type II diabetes mellitus: A meta-analysis. In Journal of Translational Medicine (Vol. 18, Issue 1). BioMed Central. https://doi.org/10.1186/s12967-020-02213-2
  • Wang, H., Lu, Y., Yan, Y., Tian, S., Zheng, D., Leng, D., Wang, C., Jiao, J., Wang, Z., & Bai, Y. (2020). Promising Treatment for Type 2 Diabetes: Fecal Microbiota Transplantation Reverses Insulin Resistance and Impaired Islets. Frontiers in Cellular and Infection Microbiology, 9. https://doi.org/10.3389/fcimb.2019.00455
  • Wang, B., Zhang, L., Wang, Y., Dai, T., Qin, Z., Zhou, F., & Zhang, L. (2022). Alterations in microbiota of patients with COVID-19: potential mechanisms and therapeutic interventions. In Signal Transduction and Targeted Therapy (Vol. 7, Issue 1). Springer Nature. https://doi.org/10.1038/s41392-022-00986-0
  • World Health Organization (WHO). 08.12.2022. https://www.who.int/health-topics/diabetes#tab=tab_1
  • Wu, H., Tremaroli, V., Schmidt, C., Lundqvist, A., Olsson, L. M., Krämer, M., Gummesson, A., Perkins, R., Bergström, G., & Bäckhed, F. (2020). The Gut Microbiota in Prediabetes and Diabetes: A Population-Based Cross-Sectional Study. Cell Metabolism, 32(3), 379-390.e3. https://doi.org/10.1016/j.cmet.2020.06.011
  • Quigley, E. M. M. (2019). Prebiotics and Probiotics in Digestive Health. In Clinical Gastroenterology and Hepatology (Vol. 17, Issue 2, pp. 333–344). W.B. Saunders. https://doi.org/10.1016/j.cgh.2018.09.028
  • Yeoh, Y. K., Zuo, T., Lui, G. C. Y., Zhang, F., Liu, Q., Li, A. Y. L., Chung, A. C. K., Cheung, C. P., Tso, E. Y. K., Fung, K. S. C., Chan, V., Ling, L., Joynt, G., Hui, D. S. C., Chow, K. M., Ng, S. S. S., Li, T. C. M., Ng, R. W. Y., Yip, T. C. F., … Ng, S. C. (2021). Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19. Gut, 70(4), 698–706. https://doi.org/10.1136/gutjnl-2020-323020
  • Zhao, L., Zhang, F., Ding, X., Wu, G., Lam, Y. Y., Wang, X., Fu, H., Xue, X., Lu, C., Ma, J., Yu, L., Xu, C., Ren, Z., Xu, Y., Xu, S., Shen, H., Zhu, X., Shi, Y., Shen, Q., … Zhang, † Chenhong. (2018). Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes. http://science.sciencemag.org/
Toplam 22 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Halk Sağlığı, Çevre Sağlığı
Bölüm Derlemeler
Yazarlar

Ayşe Betül Cingöz

Yayımlanma Tarihi 31 Aralık 2022
Gönderilme Tarihi 15 Aralık 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 4 Sayı: 2

Kaynak Göster

APA Cingöz, A. B. (2022). Bağırsak Mikrobiotası, İnsulin Direnci ve Diyabet İlişkisi. Doğal Yaşam Tıbbı Dergisi, 4(2), 31-39.
AMA Cingöz AB. Bağırsak Mikrobiotası, İnsulin Direnci ve Diyabet İlişkisi. DYT. Aralık 2022;4(2):31-39.
Chicago Cingöz, Ayşe Betül. “Bağırsak Mikrobiotası, İnsulin Direnci Ve Diyabet İlişkisi”. Doğal Yaşam Tıbbı Dergisi 4, sy. 2 (Aralık 2022): 31-39.
EndNote Cingöz AB (01 Aralık 2022) Bağırsak Mikrobiotası, İnsulin Direnci ve Diyabet İlişkisi. Doğal Yaşam Tıbbı Dergisi 4 2 31–39.
IEEE A. B. Cingöz, “Bağırsak Mikrobiotası, İnsulin Direnci ve Diyabet İlişkisi”, DYT, c. 4, sy. 2, ss. 31–39, 2022.
ISNAD Cingöz, Ayşe Betül. “Bağırsak Mikrobiotası, İnsulin Direnci Ve Diyabet İlişkisi”. Doğal Yaşam Tıbbı Dergisi 4/2 (Aralık 2022), 31-39.
JAMA Cingöz AB. Bağırsak Mikrobiotası, İnsulin Direnci ve Diyabet İlişkisi. DYT. 2022;4:31–39.
MLA Cingöz, Ayşe Betül. “Bağırsak Mikrobiotası, İnsulin Direnci Ve Diyabet İlişkisi”. Doğal Yaşam Tıbbı Dergisi, c. 4, sy. 2, 2022, ss. 31-39.
Vancouver Cingöz AB. Bağırsak Mikrobiotası, İnsulin Direnci ve Diyabet İlişkisi. DYT. 2022;4(2):31-9.
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