SPERMATOGENESİS AND DYNAMİC STEM CELLS

Yıl 2018, , 857 - 864, 10.01.2019

Şamil Öztürk , Suat Çakına Hayrunnisa Yeşil , M. İbrahim Tuğlu

https://doi.org/10.26809/joa.2018548697

Öz

Stem cell shave a tremendous therapeutic potential
with their ability to continually renew themselves and their ability to
transform into almost all mature cells in our body. In the male reproductive
system, a dynamic group of stem cells proliferates and prevents in fertility.
This process is called spermatogenesis in mammals and the testis occurs in
seminiferous tubules. Testicular stem cells, called germ stem cells (GKH) are
capable of rapid regeneration after self-renewal and injury during adult life. How
did spermatocytes occur dynamically in the later stages of old age? which is an
indispensable element of the male reproductive system and is necessary for the
continuation of the next generation. There has always been a question I asked
and the answer was sought. In our review study, the changes of spermatogonium
proliferating with mitosis in seminiferous tubules up to spermatozoa with
meiosis and stem cell reserves are discussed.

Anahtar Kelimeler

Germ stem cells, Spermatogonium, Spermatogenesis.

SPERMATOGENEZİS VE DİNAMİK KÖK HÜCRELER

Öz

Kök hücreler kendilerini sürekli yenileyebilme yetenekleri ve
vücudumuzda bulunan hemen tüm erişkin hücrelere dönüşebilme yetenekleri ile
muazzam bir terapötik potansiyele sahiptirler. Erkek üreme sisteminde dinamik
bir kök hücre grubu sürekli çoğalarak infertilite oluşumunu engellemektedir. Bu
süreç memelilerde spermatogenezis olarak adlandırılır ve testis seminifer
tübüllerinde gerçekleşir. Germ kök hücreleri (GKH) olarak adlandırılan testis
kök hücreleri, erişkinlik hayatı boyunca kendini yenileme ve hasarlanma sonrası
hızlı rejenerasyon yeteneğine sahiptirler. Erkek üreme sisteminin vazgeçilmez
unsuru olan ve bir sonraki neslin devamı için gerekli olan süreçte
spermatogenezin dinamik bir şekilde yaşlılığın ilerleyen dönemine kadar nasıl gerçekleştiği?
Her zaman sorulan ve yanıtı aranan soru olmuştur. Derleme çalışmamızda
seminifer tübüllerde mitozla çoğalan spermatogonyumların mayozla spermatid
oluncaya kadar ki değişimleri ve kök hücre rezervleri ele alınmıştır.

Anahtar Kelimeler

Germ kök hücreleri, Sprematogonyum, Spermatogenezis

Kaynakça

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