Serum Vitamin D Concentrations and Covid-19 In Pregnant Women, Does Vitamin D Supplementation Impact Results? A Comprehensive Study

Öz

Aim: Low vitamin D levels were related to an increased risk of upper respiratory tract infection and pneumonia. Vitamin D might therefore protect against symptoms of the Covid 19. The present study aims to evaluate the relationship between the acquisition and course of Covid 19 and serum vitamin D levels and investigate the prophylactic efficacy of vitamin D supplementation in pregnant women. Materials and Methods: This case-control study was conducted on 318 pregnant women admitted to our tertiary clinic to give birth between March 2020 and December 2021. All cases were tested for Covid 19 via nasopharyngeal swab. Fifty-four patients with positive PCR for SARS-CoV-2 (Group 1) were matched with 264 consecutive healthy controls (Group 2). 25 OH D Vitamin levels were measured and compared between the two groups, along with the frequency of vitamin D supplementation. Results: Group 1 showed significantly low mean 25 OH D levels, compared to Group 2 (10,22 ± 7,10 (3-37)ng/ml vs. 16,63 ± 10,80 (3,40-48,90)ng/ml, p = 0,000). Sixteen point seven % of controls and 3,7% of cases had normal Vitamin D levels (>30 ng/mL); the difference was also statistically significant (p=0,005). The frequency of vitamin D supplementation was also detected higher in controls than those with positive SARS-CoV-2 (35,6% vs. 14,8%, p=0,003). Conclusions: Sustaining adequate levels of Vitamin D may positively impact protection against Covid 19 during pregnancy. In this context, Vitamin D supplementation should be considered for the pregnant population, particularly in settings where profound vitamin D deficiency is common.

Anahtar Kelimeler

• Vitamin D deficiency
• vitamin D supplementation
• pregnancy;
• COVID-19
• D vitamini eksikliği; COVID-19; gebelik; D vitamini takviyesi.
• ; COVID-19; gebelik; D vitamini takviyesi.

Serum Vitamin D Concentrations And Covid-19 In Pregnant Women, Does Vitamin D Supplementation Impact Results? A Comprehensive Study

Öz

Amaç: Düşük D vitamini düzeylerinin üst solunum yolu enfeksiyonu ve pnömoni riskinin artmasıyla ilişkili olduğu bulundu. Bu nedenle D vitamini Covid 19 semptomlarına karşı koruma sağlayabilir. Bu çalışmanın amacı, Covid 19 edinimi ve seyri ile serum D vitamini düzeyleri arasındaki ilişkiyi değerlendirmek ve ayrıca hamile kadınlarda D vitamini takviyesinin profilaktik etkinliğini araştırmaktır. . Gereç ve Yöntem: Bu vaka-kontrol çalışması üçüncü basamak kliniğimize Mart 2020 ile Aralık 2021 tarihleri arasında doğum yapmak üzere başvuran 318 hamile kadın üzerinde yapılmıştır. Tüm vakalara nazofaringeal sürüntü ile Covid 19 testi yapılmıştır. SARS-CoV-2 için PCR pozitif olan 54 vaka (Grup 1) 264 ardışık sağlıklı kontrolle (Grup 2) eşleştirildi. 25 OH D Vitamin seviyeleri ölçüldü ve iki grup arasında D vitamini takviyesi sıklığı ile karşılaştırıldı. Bulgular: Grup 1, Grup 2'ye kıyasla (10,22 ± 7,10 (3-37) ng/ml'ye karşılık 16,63 ± 10,80 (3,40-48,90) anlamlı derecede düşük ortalama 25 OH D seviyeleri gösterdi. )ng/ml, p = 0,000). Kontrollerin %16,7'si ve vakaların %3,7'si normal D Vitamini seviyelerine sahipti (>30 ng/mL), aradaki fark da istatistiksel olarak anlamlıydı (p=0,005). D vitamini takviyesi sıklığı da kontrollerde SARS-CoV-2 pozitif olanlara göre daha yüksek saptandı (%35,6'ya karşı %14,8, p=0,003). Sonuçlar: Yeterli D vitamini seviyelerinin sürdürülmesi, hamilelik sırasında Covid 19'a karşı korunma üzerinde olumlu bir etkiye sahip olabilir. Bu içerikte; özellikle derin D vitamini eksikliğinin yaygın olduğu ortamlarda, hamile popülasyon için D vitamini takviyesi düşünülmelidir.

Anahtar Kelimeler

• COVID-19
• D vitamini takviyesi
• gebelik

Kaynakça

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