Determination of the effects of inflammatory markers on mortality in intensive care patients

Öz

Abstract Aim: Mean platelet volume (MPV), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), red cell distribution width (RDW) plays important role as effective factors in predicting mortality and morbidity in various diseases. In the present study we aimed to assess and compare MPV, NLR, PLR and RDW of survived and non-survived patients by examining the blood samples taken within the first hour after admission to our intensive care unit. Methods: This retrospective study included 672 patients who were hospitalized in a mixed 16 bed intensive care unit (ICU) between January 2019 and January 2020. By examining our hospital's computer-based data system, patient data of the survived and non-survived patients who were treated in the ICU were analyzed. Results: The demographic parameters of the patients (gender), concomitant disease, and laboratory parameters including HTC, PLT, WBC, MPV and PLR were not significantly different between the survived and non-survived patients. RDW, albumin, CRP and NLR were found statistically different between the study groups. Conclusions: The elevated RDW, NLR and CRP levels were found more significant than the other inflammatory markers for determining mortality of the critically ill patients. In addition, evaluation of albumin level was found important in defining the prognosis of the intensive care unit patients.

Anahtar Kelimeler

• Mean platelet volume
• neutrophil to lymphocyte ratio
• platelet to lymphocyte ratio
• red cell distribution width
• intensive care
• mortality

YOĞUN BAKIM HASTALARINDA İNFLAMATUAR BELİRTEÇLERİN MORTALİTE ÜZERİNE ETKİLERİNİN BELİRLENMESİ

Öz

Amaç: Ortalama trombosit hacmi (MPV), nötrofil/lenfosit oranı (NLR), trombosit/lenfosit oranı (PLR), kırmızı hücre dağılım genişliği (RDW), çeşitli hastalıklarda mortalite ve morbiditeyi öngörmede etkili faktörler olarak önemli rol oynamaktadır. Bu çalışmada, yoğun bakım ünitemize kabul edildikten sonraki ilk saat içinde alınan kan örneklerini inceleyerek sağ kalan ve yaşamayan hastaların MPV, NLR, PLR ve RDW'sini değerlendirmeyi ve karşılaştırmayı amaçladık. Materyal ve Metodlar: Bu retrospektif çalışmaya Ocak 2019-Ocak 2020 tarihleri arasında 16 yataklı karma yoğun bakım ünitesinde yatan 672 hasta dahil edildi. Hastanemizin bilgisayar tabanlı veri sistemi incelenerek yoğun bakım ünitesinde tedavi gören hayatta kalan ve hayatta kalmayan hastaların hasta verileri değerlendirildi. Sonuç: Hastaların demografik parametreleri (cinsiyet), eşlik eden hastalık ve Htc, PLT, WBC, MPV ve PLR dahil laboratuvar parametreleri, hayatta kalan ve hayatta kalmayan hastalar arasında önemli ölçüde farklı değildi. RDW, albümin, CRP ve NLR çalışma grupları arasında istatistiksel olarak farklı bulundu. Tartışma: Kritik hastalarda mortaliteyi belirlemede yüksek RDW, NLR ve CRP seviyeleri diğer inflamatuar belirteçlerden daha anlamlı bulundu. Ayrıca yoğun bakım hastalarının prognozunu belirlemede albümin düzeyinin değerlendirilmesi önemli bulundu.

Anahtar Kelimeler

• Ortalama trombosit hacmi
• nötrofil/lenfosit oranı
• trombosit/lenfosit oranı
• kırmızı hücre dağılım genişliği
• yoğun bakım
• mortalite
• Mean platelet volume
• neutrophil to lymphocyte ratio
• platelet to lymphocyte ratio
• red cell distribution width
• intensive care
• mortality

Kaynakça

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