Comparison of the Hemodynamic Response of Intravenous and Topical Lidocaine to Endotracheal Intubation

Öz

Abstract Aim: To compare the effects of 10% lidocaine spray and intravenous (IV) lidocaine on hemodynamic responses, postoperative throat pain, and coughing following laryngoscopy and endotracheal intubation. Methods: A total of 120 patients, aged 18 to 65 years and scheduled for elective surgery, were randomized into two groups: Group 1 (n=60) received 10% lidocaine spray (three puffs, 30 mg), while Group 2 (n=60) was administered 1.5 mg/kg of IV lidocaine. Intubation was performed by the same individual three minutes after mask ventilation. Systolic, diastolic, and mean arterial blood pressures, along with heart rate, were recorded at baseline and at 2, 4, 6, 8, and 10 minutes after intubation. Immediately upon transfer to the recovery unit, coughing and throat pain were assessed. The data were compared using ANOVA, Scheffe, and repeated measures tests, with the significance level being accepted as p<0.05. Results: The comparative analysis between the groups revealed a significantly lower heart rate at 1 minute after intubation in Group 2 (p=0.03). No significant differences were observed in systolic and mean arterial blood pressure measurements. Diastolic blood pressure at 10 minutes was significantly lower in Group 2 (p=0.02). Postoperative throat pain and coughing were statistically lower in Group 1 than in Group 2 at the postoperative first hour (p<0.001 and p<0.003, respectively). Conclusions: There was no significant difference in the suppression of hemodynamic responses between the groups, except for the heart rate measured at 1 minute. Throat pain and coughing were lower in the lidocaine spray group

Anahtar Kelimeler

• intubation
• hemodynamic response
• throat pain
• cough

Kaynakça

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