The Association between SGLT2 Inhibitors Use and the Risk of Contrast Induced Acute Kidney Injury in Patients with Type 2 Diabetes

Abstract

Aim: Contrast-induced acute kidney injury (CI-AKI) is associated with increased risk of morbidity and mortality and specific treatments are needed. In our study, we aimed to investigate the association of sodium-glucose cotransporter-2 inhibitors (SGLT2-I) use with the development of CI-AKI due to coronary angiography (CAG) in patients with DM. Methods: A total of 516 type 2 diabetes mellitus (DM) patients, including 250 SGLT2-I users and 266 non-SGLT2-I users, were included in our retrospective and cross-sectional study. Results: The study groups were divided into CI-AKI (+) and CI-AKI (-). SGLT2-I use was statistically significantly higher in the CI-AKI (-) group. Multivariate logistic regression analysis showed that SGLT2-I use reduced the probability of CI-AKI by 83.8%. Conclusion: Our findings suggest that SGLT2-Is may significantly reduce the risk of CI-AKI in diabetic patients undergoing CAG. In conclusion, the use of SGLT2-I may have a protective and preventive effect against the development of CI-AKI.

Keywords

• contrast induced acute kidney injury
• coroner angiography
• diabetes mellitus
• percutaneous coronary intervention
• sodium-glucose cotransporter-2 inhibitors

Tip 2 Diyabetli Hastalarda SGLT2 İnhibitörlerinin Kullanımı ile Kontrast Maddeye Bağlı Akut Böbrek Hasarı Riski Arasındaki İlişki

Öz

Amaç: Kontrast kaynaklı akut böbrek hasarı (CI-AKI) morbidite ve mortalite riskinin artmasıyla ilişkili olup spesifik tedavilere ihtiyaç duyulmaktadır. Çalışmamızda DM tanılı hastalarda Sodyum-glikoz kotransporter-2 inhibitörleri (SGLT2-I) kullanımının koroner anjiografiye (KAG) bağlı CI-AKI gelişimi ile ilişkisini araştırmayı amaçladık. Metod: Retrospektif ve kesitsel çalışmamıza elektif endikasyonlar nedeniyle KAG planlanan 250'si SGLT2-I kullanan ve 266'sı SGLT2-I kullanmayan olmak üzere toplam 516 tip 2 diyabetes mellitus (DM) hastası dahil edildi. Bulgular: Çalışma grupları CI-AKI (+) ve CI-AKI (-) olmak üzere ikiye ayrıldı. SGLT2-I kullanımı CI-AKI (-) olan grupta istatistiksel anlamlı olarak daha yüksekti. Çok değişkenli lojistik regresyon analizinde, SGLT2-I kullanımının CI-AKI olma olasılığını 83.8% azalttığı saptandı. Sonuç: Bulgularımız, SGLT2-I'lerin KAG geçiren diyabetli hastalarda CI-AKI riskini önemli ölçüde azaltabileceğini göstermektedir. Sonuç olarak SGLT2-I kullanımı CI-AKI gelişimine karşı koruyucu ve önleyici bir etkinliğe sahip olabilir.

Anahtar Kelimeler

• kontrast maddeye bağlı akut böbrek hasarı
• koroner anjiografi
• diyabetes mellitüs
• perkütan koroner girişim
• sodyum-glikoz kotransporter-2 inhibitörleri

Kaynakça

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