The Effect of Hypothermic and Normothermic Cardiopulmonary Bypass on Metabolic and Haemodynamic Parameters

Öz

Aim: The aim of this study is to investigate the changes in metabolic and haemodynamic parameters over time in patients undergoing coronary artery bypass grafting with hypothermic and normothermic cardiopulmonary bypass. Methods: A total of 126 patients were included in the study: 64 patients who underwent normothermic (35–37 °C) CPB and 62 patients who underwent hypothermic (28–34 °C) CPB. Statistical analyses were performed using SPSS 25.0 and Python software, with p<0.05 accepted as the level of significance. Results: During CPB, a decrease in albumin levels and an increase in AST, ALT, CRP, glucose, lactate, sodium, and total bilirubin levels were observed (p<0.05). However, no significant differences were found between the normothermic and hypothermic groups for most parameters (p>0.05). Conclusion: In our study, although time-dependent significant changes were observed in the metabolic and haemodynamic parameters examined in hypothermic and normothermic cases, these changes were not found to constitute a statistically significant difference between the two groups.

Anahtar Kelimeler

• Cardiopulmonary bypass
• Normothermia
• Hypothermia
• Metabolic parameters
• Systemic inflammation

Destekleyen Kurum

Harran Unıversity

Etik Beyan

It was approved by the decision numbered 12 dated 30.06.2025 of the Clinical Research Ethics Committee of Harran University Faculty of Medicine. This study was conducted in accordance with the Declaration of Helsinki, as revised in 1989.

Teşekkür

We believe our study will be beneficial to healthcare professionals working in the fields of cardiovascular surgery and perioperative care and will contribute to the scientific content of your journal. We present our article for your consideration and wish you continued success.

Hipotermik ve Normotermik Kardiyopulmoner Bypassın Metabolik ve Hemodinamik Parametreler Üzerine Etkisi

Öz

Amaç: Bu çalışmanın amacı, hipotermik ve normotermik kardiyopulmoner bypass uygulanan koroner arter bypass greftleme hastalarında metabolik ve hemodinamik parametrelerin zaman içerisindeki değişimini incelemektir. Materyal ve Metot: Çalışmaya, normotermik (35–37 °C) KPB uygulanan 64 ve hipotermik (28–34 °C) KPB uygulanan 62 olmak üzere toplam 126 hasta dahil edilmiştir. İstatistiksel analizlerde SPSS 25.0 ve Python yazılımı kullanılmış, p<0.05 anlamlılık düzeyi olarak kabul edilmiştir. Bulgular: KPB süresince albümin düzeylerinde düşüş, AST, ALT, CRP, glukoz, laktat, sodyum ve total bilirubin düzeylerinde artış gözlenmiştir (p<0.05). Ancak normotermik ve hipotermik gruplar arasında çoğu parametrede anlamlı fark bulunmamıştır (p>0.05). Sonuç: Çalışmamızda hipotermik ve normotermik olgularda incelenen metabolik ve hemodinamik parametrelerde zamana bağlı belirgin değişimler görülmekle birlikte, bu değişimlerin iki grup arasında istatistiksel olarak anlamlı bir fark oluşturmadığı saptanmıştır.

Anahtar Kelimeler

• Kardiyopulmoner bypass
• Normotermi
• Hipotermi
• Metabolik parametreler
• Sistemik inflamasyon

Destekleyen Kurum

Harran Üniversitesi

Etik Beyan

Harran Üniversitesi Tıp Fakültesi Klinik Araştırmalar Etik Kurulu'nun 30.06.2025 tarih ve 12 sayılı kararıyla onaylanmıştır. Bu çalışma, 1989 yılında revize edilen Helsinki Bildirgesi'ne uygun olarak yürütülmüştür.

Teşekkür

Çalışmamızın, kardiyovasküler cerrahi ve perioperatif bakım alanlarında çalışan sağlık profesyonelleri için faydalı olacağını ve derginizin bilimsel içeriğine katkı sağlayacağını düşünmekteyiz. Değerli hakemlerinizin değerlendirmelerine sunulmak üzere makalemizi takdirlerinize arz eder, iyi çalışmalar dilerim.

Kaynakça

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