The Effect of Hypothermic and Normothermic Cardiopulmonary Bypass on Metabolic and Haemodynamic Parameters

Abstract

Aim: The aim of this study is to investigate the changes in metabolic and haemodynamic parameters over time in patients undergoing coronary artery bypass grafting with hypothermic and normothermic cardiopulmonary bypass. Methods: A total of 126 patients were included in the study: 64 patients who underwent normothermic (35–37 °C) CPB and 62 patients who underwent hypothermic (28–34 °C) CPB. Statistical analyses were performed using SPSS 25.0 and Python software, with p<0.05 accepted as the level of significance. Results: During CPB, a decrease in albumin levels and an increase in AST, ALT, CRP, glucose, lactate, sodium, and total bilirubin levels were observed (p<0.05). However, no significant differences were found between the normothermic and hypothermic groups for most parameters (p>0.05). Conclusion: In our study, although time-dependent significant changes were observed in the metabolic and haemodynamic parameters examined in hypothermic and normothermic cases, these changes were not found to constitute a statistically significant difference between the two groups.

Keywords

• Cardiopulmonary bypass
• Normothermia
• Hypothermia
• Metabolic parameters
• Systemic inflammation

Hipotermik ve Normotermik Kardiyopulmoner Bypassın Metabolik ve Hemodinamik Parametreler Üzerine Etkisi

Öz

Amaç: Bu çalışmanın amacı, hipotermik ve normotermik kardiyopulmoner bypass uygulanan koroner arter bypass greftleme hastalarında metabolik ve hemodinamik parametrelerin zaman içerisindeki değişimini incelemektir. Materyal ve Metot: Çalışmaya, normotermik (35–37 °C) KPB uygulanan 64 ve hipotermik (28–34 °C) KPB uygulanan 62 olmak üzere toplam 126 hasta dahil edilmiştir. İstatistiksel analizlerde SPSS 25.0 ve Python yazılımı kullanılmış, p<0.05 anlamlılık düzeyi olarak kabul edilmiştir. Bulgular: KPB süresince albümin düzeylerinde düşüş, AST, ALT, CRP, glukoz, laktat, sodyum ve total bilirubin düzeylerinde artış gözlenmiştir (p<0.05). Ancak normotermik ve hipotermik gruplar arasında çoğu parametrede anlamlı fark bulunmamıştır (p>0.05). Sonuç: Çalışmamızda hipotermik ve normotermik olgularda incelenen metabolik ve hemodinamik parametrelerde zamana bağlı belirgin değişimler görülmekle birlikte, bu değişimlerin iki grup arasında istatistiksel olarak anlamlı bir fark oluşturmadığı saptanmıştır.

Anahtar Kelimeler

• Kardiyopulmoner bypass
• Normotermi
• Hipotermi
• Metabolik parametreler
• Sistemik inflamasyon

Kaynakça

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