Post-Cardiopulmonary Bypass Alterations in Liver Delta Ratio: A Retrospective Clinical Study

Yıl 2026, Cilt: 9 Sayı: 1, 169 - 174, 17.03.2026

Yasemin Hacanlı , Murat Ziya Bağış , Kadir Eği

https://izlik.org/JA88JS87NJ

Öz

Aim: To investigate the effect of cardiopulmonary bypass on the liver using data obtained from differences in liver-related blood parameters in blood samples taken before and after coronary artery bypass grafting surgery.
Methods: This retrospective study included a total of 88 patients who underwent coronary artery bypass graft surgery. A difference analysis was performed for AST, ALT, LDH, CRP, RBC, Hct, albumin, CRP, lactate, K, and bilirubin levels. Kruskal–Wallis and correlation analyses were used to evaluate the relationships between the differences in the data.
Results: When preoperative and postoperative values were compared, significant differences were found between AST difference ALT, AST difference LDH, ALT difference LDH, ALT difference CRP, LDH difference CRP, RBC difference Hct, and Albumin difference CRP (p<0.05). GGT, albumin, Hct, RBC, and potassium levels decreased significantly (p<0.05).
Conclusıon: Significant increases in AST, ALT, LDH, total and direct bilirubin, and CRP levels were observed in the postoperative period, while significant decreases were observed in albumin, Hct, and RBC counts. The increase in AST levels was found to be related to the total perfusion time, while the increase in LDH was sensitive to the cross-clamp time.

Anahtar Kelimeler

Liver parameters , Cardiopulmonary bypass , Cardiopulmonary bypass and hematological parameters , De Ritis

Etik Beyan

Ethical approval for the study was obtained from the Harran University Clinical Research Ethics Committee (Decision No: HRÜ/25.13.57, Date: 14.07.2025).

Destekleyen Kurum

There is no supporting institution

Kardiyopulmoner Bypass Sonrası Karaciğer Delta Oranındaki Değişiklikler: Retrospektif Klinik Çalışma

https://izlik.org/JA88JS87NJ

Öz

Amaç: Koroner arter bypass greftleme cerrahisi öncesi ve sonrası alınan kan örneklerinde karaciğerle ilişkili kan parametrelerindeki farklılıklardan elde edilen veriler kullanılarak, kardiyopulmoner bypassın karaciğer üzerindeki etkisini araştırmak.
Materyal ve Metot: Bu retrospektif çalışmaya koroner arter bypass greft ameliyatı geçiren toplam 88 hasta dâhil edildi. AST, ALT, LDH, CRP, RBC, Hct, albümin, laktat, potasyum ve bilirubin düzeyleri için fark analizi yapıldı. Verilerdeki farklar arasındaki ilişkileri değerlendirmek amacıyla Kruskal–Wallis ve korelasyon analizleri kullanıldı.
Bulgular: Preoperatif ve postoperatif değerler karşılaştırıldığında; AST farkı–ALT, AST farkı–LDH, ALT farkı–LDH, ALT farkı–CRP, LDH farkı–CRP, RBC farkı–Hct ve Albümin farkı–CRP arasında anlamlı farklılıklar bulundu (p<0.05). GGT, albümin, Hct, RBC ve potasyum düzeylerinde anlamlı düşüşler saptandı (p<0.05).
Sonuç: Postoperatif dönemde AST, ALT, LDH, total ve direkt bilirubin ile CRP düzeylerinde belirgin artışlar gözlenirken, albümin, Hct ve RBC sayılarında anlamlı düşüşler saptandı. AST düzeylerindeki artışın toplam perfüzyon süresiyle ilişkili olduğu, LDH artışının ise kros-klemp süresine duyarlı olduğu görüldü.

Anahtar Kelimeler

Karaciğer parametreleri , Kardiyopulmoner bypass , Kardiyopulmoner bypass ve hematolojik parametreler , De Ritis

Etik Beyan

Çalışma için etik onay Harran Üniversitesi Klinik Araştırma Etik Komitesi'nden alınmıştır (Karar No: HRÜ/25.13.57, Tarih: 14.07.2025).

Destekleyen Kurum

Destekleyen kurum bulunmamaktadır

Kaynakça

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