The Effect of Resveratrol in Alleviating Ovarian Tissue Damage in Cadmium-Induced Rats

Öz

Cadmium (Cd) exposure leads to severe histological damage (follicular atresia, granulosa cell degeneration) and increased oxidative stress in rat ovarian tissue. This study investigates the protective potential of resveratrol (RES) against these toxic effects. Histologically, RES treatment significantly mitigated Cd-induced structural damage, preserving follicular health and stromal integrity. Biochemical analyses showed that RES reduced Cd-induced lipid peroxidation (MDA) and nitrosative stress (NO), while also restoring suppressed antioxidant enzyme (SOD, CAT, GPx) activities and glutathione (GSH) levels. Bioinformatic integration supports these experimental findings, revealing that the effects of RES are based on modulating interconnected pathways such as apoptotic signaling and Nrf2-mediated antioxidant defense. In conclusion, resveratrol stands out as a versatile and effective protective agent against cadmium-induced ovarian toxicity due to its antioxidant and anti-apoptotic properties. Keywords: Ovary, oxidative stress, apoptosis, cadmium, toxicity

Anahtar Kelimeler

• Ovary
• oxidative stress
• apoptosis
• cadmium
• toxicity

Destekleyen Kurum

Yok

Etik Beyan

This study was approved by the Çanakkale Experimental Animal Ethics Committee (05.03.2021, Decision No: 2021/02-07).

Teşekkür

Yok

Kadmiyum ile İndüklenen Sıçanların Ovaryan Doku Hasarının Hafifletilmesinde Resveratrol'ün Etkisi

Öz

Kadmiyum (Cd) maruziyeti, sıçan over dokusunda ciddi histolojik bozulmaya (foliküler atrezi, granüloza hücre dejenerasyonu) ve artmış oksidatif strese yol açar. Bu çalışma, resveratrolün (RES) bu toksik etkilere karşı koruyucu potansiyelini araştırmaktadır. Histolojik olarak, RES tedavisi, Cd'nin neden olduğu yapısal hasarı belirgin şekilde hafifletmiş, foliküler sağlığı ve stromal bütünlüğü korumuştur. Biyokimyasal analizler, RES'nin Cd ile indüklenen lipid peroksidasyonunu (MDA) ve nitrozatif stresi (NO) azalttığını, aynı zamanda baskılanmış antioksidan enzim (SOD, CAT, GPx) aktivitelerini ve glutatyon (GSH) seviyelerini restore ettiğini göstermiştir. Biyoinformatik entegrasyon, bu deneysel bulguları destekleyerek, RES'nin etkilerinin apoptotik sinyalizasyon, Nrf2 mediyatörlü antioksidan savunma gibi birbiriyle bağlantılı yolakları modüle etmeye dayandığını ortaya koymaktadır. Sonuç olarak, resveratrol, antioksidan ve anti-apoptotik özellikleri ile kadmiyum kaynaklı over toksisitesine karşı çok yönlü ve etkili bir koruyucu ajan olarak öne çıkmaktadır. Anahtar kelimeler: Ovaryum, oksidatif stres, apoptoz, kadmiyum, toksisite

Anahtar Kelimeler

• Ovaryum
• oksidatif stres
• apoptoz
• kadmiyum
• toksisite

Destekleyen Kurum

Yok

Etik Beyan

This study was approved by the Çanakkale Experimental Animal Ethics Committee (05.03.2021, Decision No: 2021/02-07).

Teşekkür

Yok

Kaynakça

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