Eritrosit Dağılım Genişliği (RDW)’nin Kronik Venöz Yetmezlikte Tanı Aracı Olarak Kullanımı

Öz

Giriş Kronik venöz yetmezlik (KVY) kronik bir enflamatuar hastalıktır ve yayınlanan çalışmalarda bazı biyobelirteçlerin KVY hastaları için prediktif değeri olduğu gösterilmiştir. Eritrosit dağılım genişliği (RDW), dolaşımdaki eritrositlerin heterojenliğinin bir ölçüsüdür. Biz bu çalışma ile RDW ve KVY sınıflandırması arasındaki ilişkiyi araştırmayı amaçladık. Gereç ve Yöntemler Bu çalışmada alt ekstremite venöz Doppler ultrasonu çekilmiş 102 hasta değerlendirildi. Doppler ultrason sonuçları, hematolojik ve biyokimyasal laboratuvar sonuçları retrospektif olarak hastane tıbbi kayıtlarından elde edildi. Çalışma popülasyonu Doppler ultrason sonuçlarına göre kronik venöz yetmezlik grubu ve kontrol grubuna ayrıldı. Kronik venöz yetmezlik grubu CEAP sınıflandırmasının klinik bulgularına göre sınıflandırıldı. Bulgular Toplam 102 hasta çalışmaya dahil edildi. Çalışma popülasyonunun ortalama yaşı 52.3±14.6 ve 54'ü (%52,9) erkekti. Hastaların% 25,5'i CVI grubuna,% 74,5'i kontrol grubuna alındı. Çalışma popülasyonunun CEAP sınıflandırmasının klinik bulgularına göre % 21,6'sı (n=26) Sınıf 1, %44,1'i (n=45) Sınıf 2 ve %8,8'i (n=9) Sınıf 3 olarak sınıflandırıldı. RDW, venöz yetmezlik grubunda kontrol grubuna göre anlamlı derecede yüksekti (p = 0.02). İkili karşılaştırmada; Sınıf 1 ile Sınıf 2 arasında p= 0,150; Sınıf 1 ile Sınıf 3 arasında p = 0,125 ve Sınıf 2 ile Sınıf 3 arasında p= 0,05 saptandı. Sonuç: Sonuçlarımız RDW'nin CVI için bir tanı aracı olarak kullanılabileceğini, ancak CVI'nın şiddetinin RDW tarafından belirlenemeyeceğini göstermektedir.

Anahtar Kelimeler

• Eritrosit Dağılım Genişliği
• RDW
• Kronik Venöz Yetmezlik
• Kronik Venöz Yetmezlik Sınıflaması

Red Cell Distribution Width (RDW) as a Diagnostic Tool for Chronic Venous Insufficiency

Öz

Introduction Chronic venous insufficiency (CVI) is a chronic inflammatory disease and biomarkers are defined to be used as predictive biomarkers for CVI patients. Red cell distribution width (RDW) is a measure of heterogeneity of erythrocytes in circulation. With this study we aim to investigate the relationship between RDW and CVI classification Materials and Methods 102 consecutive patients with lower extremity venous Doppler ultrasound were evaluated for the study. The Doppler ultrasound results, hematological and biochemical laboratory results were obtained retrospectively from hospital medical records. The study population was divided to chronic venous insufficiency group and control group according to Doppler ultrasound results. Chronic venous insufficiency group also classified according to clinical findings of CEAP classification Results A total of 102 patients were included in the study. Mean age of the study population was 52.3 ± 14.6 and 54 (52.9%) was male. 25.5% of the patients were included in CVI group and 74.5% of the patients were included in the control group. 21.6% (n=26) of the study population was classified as Class 1, 44.1% (n=45) was classified as Class 2 and 8.8% (n=9) of the patients were classified as Class3 according to the clinical findings of the CEAP classification. RDW was significantly higher in venous insufficiency group compared to control group (p=0.02). The pairwise comparison of Class 1 to Class 2 was 0.150, Class 1 to Class 3 was p=0.125 and Class 2 to Class 3 was 0.05. Conclusion Our results propose that RDW may be used as a diagnostic tool for CVI but severity of CVI cannot be determined by RDW.

Anahtar Kelimeler

• Red cell distribution width
• RDW
• Chronic venous insufficiency
• Chronic venous insufficiency classification

Kaynakça

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