Can Fibulin-5 Induce Gastrointestinal Stromal Tumor Development?

Meryem İlkay Eren Karanis; Hande Köksal

Can Fibulin-5 Induce Gastrointestinal Stromal Tumor Development?

Öz

Objective: Gastrointestinal stromal tumors are the most common primary mesenchymal tumors of the gastrointestinal tract and show Cajal cell differentiation. Fibulin-5 is a multifunctional extracellular matrix protein that inhibits epithelial and endothelial cell proliferation. Expression of fibulin-5 is down-regulated in various carcinomas. In contrast, fibulin-5 stimulates fibroblast and fibrosarcoma cells. In this study we aimed to investigate the expression of fibulin-5 in Cajal cells and gastrointestinal stromal tumors. Materials and Methods: Immunohistochemical fibulin-5 staining is performed on 34 (22 gastric and 12 small intestinal) gastrointestinal stromal tumors. Fibulin-5 staining intensity was scored in 4 quantitative categories and compared with clinicopathological features of the patients. Results: There was no staining in 4 of the gastrointestinal stromal tumors; weak staining in 20 cases, moderate staining in 6 cases, and strong staining in 4 cases were observed. In 3 cases Cajal cells were detected with fibulin-5 by moderately staining. The relationship between fibulin-5 staining intensity and age and gender of the cases, localization, size, grade, and the risk groups of the tumors wasn’t statistically significant. Conclusion: A great proportion of gastrointestinal stromal tumors show fibulin-5 expression, even if weak, in contrast to the infrequent fibulin-5 expression in Cajal cells. Based on these findings, it can be speculated that the expression of fibulin-5 in Cajal cells can be increase cell proliferation, but it would be useful to conduct new studies with larger series to clarify this issue. There is no correlation between fibulin-5 expression intensity and clinicopathological and prognostic data of gastrointestinal stromal tumors.

Anahtar Kelimeler

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Klinik Tıp Bilimleri

Bölüm

Araştırma Makalesi

Yazarlar

Meryem İlkay Eren Karanis ^*
0000-0002-1097-4592
Türkiye

Hande Köksal
0000-0002-9668-7913
Türkiye

Yayımlanma Tarihi

31 Aralık 2020

Gönderilme Tarihi

2 Kasım 2020

Kabul Tarihi

14 Aralık 2020

Yayımlandığı Sayı

Yıl 2020 Cilt: 3 Sayı: 3

IZ

https://izlik.org/JA53JL24SB

Kaynak Göster

RIS / Bibtex

APA

Eren Karanis, M. İ., & Köksal, H. (2020). Can Fibulin-5 Induce Gastrointestinal Stromal Tumor Development? Journal of Cukurova Anesthesia and Surgical Sciences, 3(3), 275-285. https://izlik.org/JA53JL24SB

AMA

1.Eren Karanis Mİ, Köksal H. Can Fibulin-5 Induce Gastrointestinal Stromal Tumor Development? J Cukurova Anesth Surg. 2020;3(3):275-285. https://izlik.org/JA53JL24SB

Chicago

Eren Karanis, Meryem İlkay, ve Hande Köksal. 2020. “Can Fibulin-5 Induce Gastrointestinal Stromal Tumor Development?”. Journal of Cukurova Anesthesia and Surgical Sciences 3 (3): 275-85. https://izlik.org/JA53JL24SB.

EndNote

Eren Karanis Mİ, Köksal H (01 Aralık 2020) Can Fibulin-5 Induce Gastrointestinal Stromal Tumor Development? Journal of Cukurova Anesthesia and Surgical Sciences 3 3 275–285.

IEEE

[1]M. İ. Eren Karanis ve H. Köksal, “Can Fibulin-5 Induce Gastrointestinal Stromal Tumor Development?”, J Cukurova Anesth Surg, c. 3, sy 3, ss. 275–285, Ara. 2020, [çevrimiçi]. Erişim adresi: https://izlik.org/JA53JL24SB

ISNAD

Eren Karanis, Meryem İlkay - Köksal, Hande. “Can Fibulin-5 Induce Gastrointestinal Stromal Tumor Development?”. Journal of Cukurova Anesthesia and Surgical Sciences 3/3 (01 Aralık 2020): 275-285. https://izlik.org/JA53JL24SB.

JAMA

1.Eren Karanis Mİ, Köksal H. Can Fibulin-5 Induce Gastrointestinal Stromal Tumor Development? J Cukurova Anesth Surg. 2020;3:275–285.

MLA

Eren Karanis, Meryem İlkay, ve Hande Köksal. “Can Fibulin-5 Induce Gastrointestinal Stromal Tumor Development?”. Journal of Cukurova Anesthesia and Surgical Sciences, c. 3, sy 3, Aralık 2020, ss. 275-8, https://izlik.org/JA53JL24SB.

Vancouver

1.Meryem İlkay Eren Karanis, Hande Köksal. Can Fibulin-5 Induce Gastrointestinal Stromal Tumor Development? J Cukurova Anesth Surg [Internet]. 01 Aralık 2020;3(3):275-8. Erişim adresi: https://izlik.org/JA53JL24SB