Lynch sendromunda profilaktik cerrahi: Ne zaman ve nasıl?– Güncel yaklaşımlar ve literatür derlemesi

Yıl 2021, Cilt: 4 Sayı: 1, 37 - 44, 30.04.2021

Emrah Akın , Uğur Can Dülger , Fatih Altıntoprak

Öz

Lynch sendromu; kolorektal kansere dönüşen soliter adenomlar ve ekstra-kolonik manifestasyonlarla karakterize, otozomal dominant kalıtımlı bir kanser predispozan sendromdur. Sendromun tanısı klinik bulgular, patolojik özellikler, aile öyküsü ve genetik testler ile koyulabilir. Lynch Sendromu riski altında olan bireylerde tarama çalışmalarına 20’ li yaşlardan itibaren başlanmalı, mutasyon pozitif taşıyıcılarında yıllık olarak devam edilmeli ve belli şartların varlığında da da profilaktik cerrahi gündeme alınmalıdır.

Anahtar Kelimeler

LYNCH sendromu, Herediter polipozis sendromu, Profilaktik cerrahi

Kaynakça

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