Correlation of Patient Features of Covid-19, Laboratory Tests and Computed Tomography Findings: Single-Center Retrospective Study

Yıl 2022, Cilt: 5 Sayı: 3, 288 - 294, 31.12.2022

Sevgül Köse , Umur Anıl Pehlivan , Ferit Kuşcu , Yasemin Saygideger , Oya Baydar Toprak , Bilen Onan , Nazli Nida Kaya , Aslıhan Candevir

https://doi.org/10.36516/jocass.1149571

Öz

Aim: Computed Tomography (CT) findings, clinical and laboratory data are very important in the diagnosis and treatment process of Coronavirus Disease 2019 (COVID-19). In this study, the relationship between these findings was investigated.
Material and method: 93 patients with positive Reverse-Transcriptase Polymerase Chain Reaction (RT-PCR) test for SARS-CoV-2 were included in the study. CT findings, laboratory tests, and the World Health Organization Clinical Progress Scale (WHO-CPS) were evaluated.
Results: Of the patients, 52 were male and 41 were female. The mean age was 46. The most common laboratory finding is high CRP levels (67.74%). GGO, consolidation, halo sign and air bronchogram were most frequent CT findings. The mean of CT score was 4.91. A statistically significant positive correlation was found between CT score and age, D-dimer, CRP, ferritin and fibrinogen. There was a significant negative correlation between CT score, lymphocyte count and oxygen saturation. There was no correlation between CT score and procalcitonin, gender and presence of comorbid disease. There was a moderate negative correlation between CT score and IL-6 blocker use and corticosteroid therapy, and a mild negative correlation between CT score and favipravir use. The correlation between CT score and immunosuppressant use was not significant. We also found a moderate positive correlation between WHO-CPS and CT scores.
Conclusion: The CT score is correlated with some laboratory and clinical markers, and we think that these findings indicate that CT is a very useful test in the diagnosis as well as in the follow-up.

Anahtar Kelimeler

COVID-19, CT, laboratory findings

COVID-19'UN HASTA ÖZELLİKLERİ, LABORATUVAR TESTLERİ VE BİLGİSAYARLI TOMOGRAFİ BULGULARININ KORELASYONU: TEK MERKEZLİ RETROSPEKTİF ÇALIŞMA

Öz

Amaç: Koronavirüs Hastalığı 2019 (COVID-19) tanı ve tedavi sürecinde Bilgisayarlı Tomografi (BT) bulguları, klinik ve laboratuvar verileri çok önemlidir. Bu çalışmada, bu bulgular arasındaki ilişki araştırılmıştır.
Materyal ve metod: SARS-CoV-2 için Revers-Transkriptaz Polimeraz Zincir Reaksiyonu (RT-PCR) testi pozitif çıkan 93 hasta çalışmaya dahil edildi. BT bulguları, laboratuvar testleri ve Dünya Sağlık Örgütü Klinik İlerleme Ölçeği (DSÖ-KİÖ)değerlendirildi.
Bulgular: Hastaların 52’si erkek, 41’I kadındı. Ortalama yaş 46 idi. En sık görülen laboratuvar bulgusu yüksek CRP düzeyleridir (%67,74). Buzlu cam, konsolidasyon, halo işareti ve hava bronkogramı en sık BT bulgularıydı. BT skorunun ortalaması 4.91 idi. BT skoru ile yaş, D-dimer, CRP, ferritin ve fibrinojen arasında istatistiksel olarak anlamlı pozitif korelasyon bulundu. BT skoru ile lenfosit sayısı ve oksijen satürasyonu arasında anlamlı negatif korelasyon mevcuttu. BT skoru ile prokalsitonin, cinsiyet ve komorbid hastalık varlığı arasında korelasyon yoktu. BT skoru ile IL-6 bloker kullanımı ve kortikosteroid tedavisi arasında orta derecede negatif korelasyon, BT skoru ile favipravir kullanımı arasında hafif negatif korelasyon vardı. BT skoru ile immünosupresan kullanımı arasındaki korelasyon anlamlı değildi. Ayrıca DSÖ-KİÖ ve BT skorları arasında orta düzeyde pozitif korelasyon bulduk.
Sonuç: BT skoru bazı laboratuvar ve klinik belirteçlerle korelasyon göstermekte olup bu bulguların BT’nin tanıda olduğu kadar takipte de oldukça yararlı bir tetkik olduğuna işaret ettiğini düşünmekteyiz.

Anahtar Kelimeler

COVID-19, BT, laboratuvar bulguları

Kaynakça

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