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The role of serum ferritin, vitamin B12 and vitamin D levels in childhood primary headaches

Yıl 2023, Cilt: 6 Sayı: 3, 411 - 415, 31.12.2023
https://doi.org/10.36516/jocass.1356182

Öz

Aim: In this study, it was aimed to investigate the relationship between headache components and serum ferritin, vitamin B12 and vitamin D levels in pediatric patients with migraine and tension-type headache (TTH).
Methods: The data of patients aged 7-17 years who applied to the outpatient pediatric neurology clinic with a complaint of headache and were diagnosed with migraine and TTH based on the International Classification of Headache Disorder (ICHD)-3 beta criteria were evaluated retrospectively.
Results: The mean age of the patients was 13.80 ± 3.89 years in the migraine group and 14.10± 4.17 years in the TTH group. In the migraine group, the duration of the attack was longer and the pain intensity was higher. Unilateral headache, throbbing character, nausea, vomiting, discomfort from light and sound were statistically significantly higher in the migraine group. In patients with migraine, low vitamin D and low ferritin levels were associated with a prolongation of the disease duration and an increase in the frequency of attacks. A decrease in serum iron level was associated with an increase in pain severity and a decrease in vitamin D levels was associated with an increase in attack duration. It was observed that there was an increase in the frequency of attacks with a decrease in serum ferritin levels in the TTH group. No statistically significant correlation was found between headache characteristics and vitamin B12.
Conclusions: Our study shows the necessity of routine evaluation of vitamin D and ferritin levels in childhood primary headaches.

Kaynakça

  • 1. Ozge A, Termine C, Antonaci F, et al. Overview of diagnosis and management of paediatric headache. Part I: diagnosis. J Headache Pain. 2011;12(1):13-23. doi:10.1007/s10194-011-0297-5
  • 2. Dooley JM, Gordon KE, Wood EP. Self-reported headache frequency in Canadian adolescents: validation and follow-up. Headache. 2005;45(2):127-131. doi:10.1111/j.1526-4610.2005.05026.x
  • 3. Rhee H. Prevalence and predictors of headaches in US adolescents. Headache. 2000;40(7):528-538. doi:10.1046/j.1526-4610.2000.00084.x
  • 4. Brna PM, Dooley JM. Headaches in the pediatric population. Semin Pediatr Neurol. 2006;13(4):222-230. doi:10.1016/j.spen.2006.09.003
  • 5. Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia. 2013;33(9):629-808. doi:10.1177/0333102413485658
  • 6. Hershey AD, Powers SW, Vockell AL, et al. Development of a patient-based grading scale for PedMIDAS. Cephalalgia. 2004;24(10):844-849. doi:10.1111/j.1468-2982.2004.00757.x
  • 7. Prakash S, Mehta NC, Dabhi AS, et al. The prevalence of headache may be related with the latitude: a possible role of Vitamin D insufficiency?. J Headache Pain. 2010;11(4):301-307. doi:10.1007/s10194-010-0223-2
  • 8. Song TJ, Chu MK, Sohn JH, et al. Effect of Vitamin D Deficiency on the Frequency of Headaches in Migraine. J Clin Neurol. 2018;14(3):366-373. doi:10.3988/jcn.2018.14.3.366
  • 9. Rapisarda L, Mazza MR, Tosto F, et al. Relationship between severity of migraine and vitamin D deficiency: a case-control study. Neurol Sci. 2018;39(Suppl 1):167-168. doi:10.1007/s10072-018-3384-4
  • 10. Tozzi E, Boncristiano A, Antenucci A, et al. P013. 25(OH) D Level and headache in children sample. J Headache Pain. 2015;16(Suppl 1):A84. doi:10.1186/1129-2377-16-S1-A84
  • 11. Donmez A, Orun E, Sonmez FM. Vitamin D status in children with headache: A case-control study. Clin Nutr ESPEN. 2018;23:222-227. doi:10.1016/j.clnesp.2017.09.010
  • 12. Kjaergaard M, Eggen AE, Mathiesen EB, et al. Association between headache and serum 25-hydroxyvitamin D: the Tromsø Study: Tromsø 6. Headache. 2012;52(10):1499-1505. doi:10.1111/j.1526-4610.2012.02250.x
  • 13. Zandifar A, Masjedi SS, Banihashemi M, et al. Vitamin D status in migraine patients: a case-control study. Biomed Res Int. 2014;2014:514782. doi:10.1155/2014/514782
  • 14. Vuković-Cvetković V, Plavec D, Lovrencić-Huzjan A, et al. Is iron deficiency anemia related to menstrual migraine? Post hoc analysis of an observational study evaluating clinical characteristics of patients with menstrual migraine. Acta Clin Croat. 2010;49(4):389-394.
  • 15. Fallah R, Zare Bidoki S, Ordooei M. Evaluation Efficacy of Ferrous Sulfate Therapy on Headaches of 5-15 Years Old Iron Deficient Children with Migraine. Iran J Ped Hematol Oncol. 2016;6(1):32-37.
  • 16. Gür-Özmen S, Karahan-Özcan R. Iron Deficiency Anemia Is Associated with Menstrual Migraine: A Case-Control Study. Pain Med. 2016;17(3):596-605. doi:10.1093/pm/pnv029
  • 17. Demirel H, Emre U, Atasoy HT ve ark. Migren ve epizodik gerilim tipi baş ağrıları ile hematolojik parametrelerin ilişkisi. Türk Nöroloji Dergisi 2008; 14(6):394-398.
  • 18. Acar A, Evliyaoğlu O, Uzar E ve ark. Migren hastalarında serum vitamin B12, folik asit ve ferritin düzeyleri. Turk Norol Derg 2011;17: 90-95.
  • 19. Nelson KB, Richardson AK, He J, et al. Headache and biomarkers predictive of vascular disease in a representative sample of US children. Arch Pediatr Adolesc Med. 2010;164(4):358-362. doi:10.1001/archpediatrics.2010.17
  • 20. Bottini F, Celle ME, Calevo MG, et al. Metabolic and genetic risk factors for migraine in children. Cephalalgia. 2006;26(6):731-737. doi:10.1111/j.1468-2982.2006.01107.x
  • 21. Lea R, Colson N, Quinlan S, et al. The effects of vitamin supplementation and MTHFR (C677T) genotype on homocysteine-lowering and migraine disability. Pharmacogenet Genomics. 2009;19(6):422-428. doi:10.1097/FPC.0b013e32832af5a3
  • 22. Menon S, Lea RA, Roy B, et al. Genotypes of the MTHFR C677T and MTRR A66G genes act independently to reduce migraine disability in response to vitamin supplementation. Pharmacogenet Genomics. 2012;22(10):741-749. doi:10.1097/FPC.0b013e3283576b6b

Çocukluk çağı birincil baş ağrılarında serum ferritin, vitamin B12 ve vitamin D düzeylerinin rolü

Yıl 2023, Cilt: 6 Sayı: 3, 411 - 415, 31.12.2023
https://doi.org/10.36516/jocass.1356182

Öz

Amaç: Bu çalışmada migren ve gerilim tipi baş ağrısı (GTBA) tanılı hastalarda baş ağrı bileşenleri ile serum ferritin, vitamin B12 ve vitamin D düzeyi arasındaki ilişkinin araştırılması amaçlandı.
Gereç ve Yöntemler: Baş ağrısı yakınması ile çocuk nöroloji polikliniğine başvuran, Baş Ağrısı Bozukluğunun Uluslararası Sınıflaması (ICHD)-3 beta kriterleri temel alınarak migren ve GTBA tanısı alan 7-17 yaş arasındaki hastaların verileri retrospektif olarak değerlendirildi.
Bulgular: Hastaların yaş ortalaması migren grubunda 13.80 ±3.89 ve GTBA grubunda 14.10±4.17 yaştı. Migren grubunda atak süresi daha uzundu ve ağrı şiddeti daha fazlaydı. Baş ağrısının tek taraflı olması, zonklayıcı vasıfta olması, bulantı, kusma, ışıktan ve sesten rahatsızlık olması migren grubunda istatistiksel anlamlı olarak daha yüksekti. Migrenli hastalarda düşük vitamin D ve düşük ferritin düzeyi, hastalık süresinde uzama ve atak sıklığında artış ile ilişkili bulundu. Serum demir seviyesinde azalma ağrı şiddetinde artış, vitamin D düzeyinde azalma atak süresinde artış ile ilişkilendirildi. GTBA grubunda serum ferritin düzeyinde azalma ile atak sıklığında artış olduğu gözlendi. Baş ağrısı özellikleri ile B12 vitamini arasında istatistiksel anlamlı bir ilişki saptanmadı.
Sonuç: Çalışmamız çocukluk çağı birincil baş ağrılarında vitamin D ve ferritin düzeylerinin rutin olarak değerlendirilmesinin gerekliliğini göstermektedir. .

Kaynakça

  • 1. Ozge A, Termine C, Antonaci F, et al. Overview of diagnosis and management of paediatric headache. Part I: diagnosis. J Headache Pain. 2011;12(1):13-23. doi:10.1007/s10194-011-0297-5
  • 2. Dooley JM, Gordon KE, Wood EP. Self-reported headache frequency in Canadian adolescents: validation and follow-up. Headache. 2005;45(2):127-131. doi:10.1111/j.1526-4610.2005.05026.x
  • 3. Rhee H. Prevalence and predictors of headaches in US adolescents. Headache. 2000;40(7):528-538. doi:10.1046/j.1526-4610.2000.00084.x
  • 4. Brna PM, Dooley JM. Headaches in the pediatric population. Semin Pediatr Neurol. 2006;13(4):222-230. doi:10.1016/j.spen.2006.09.003
  • 5. Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia. 2013;33(9):629-808. doi:10.1177/0333102413485658
  • 6. Hershey AD, Powers SW, Vockell AL, et al. Development of a patient-based grading scale for PedMIDAS. Cephalalgia. 2004;24(10):844-849. doi:10.1111/j.1468-2982.2004.00757.x
  • 7. Prakash S, Mehta NC, Dabhi AS, et al. The prevalence of headache may be related with the latitude: a possible role of Vitamin D insufficiency?. J Headache Pain. 2010;11(4):301-307. doi:10.1007/s10194-010-0223-2
  • 8. Song TJ, Chu MK, Sohn JH, et al. Effect of Vitamin D Deficiency on the Frequency of Headaches in Migraine. J Clin Neurol. 2018;14(3):366-373. doi:10.3988/jcn.2018.14.3.366
  • 9. Rapisarda L, Mazza MR, Tosto F, et al. Relationship between severity of migraine and vitamin D deficiency: a case-control study. Neurol Sci. 2018;39(Suppl 1):167-168. doi:10.1007/s10072-018-3384-4
  • 10. Tozzi E, Boncristiano A, Antenucci A, et al. P013. 25(OH) D Level and headache in children sample. J Headache Pain. 2015;16(Suppl 1):A84. doi:10.1186/1129-2377-16-S1-A84
  • 11. Donmez A, Orun E, Sonmez FM. Vitamin D status in children with headache: A case-control study. Clin Nutr ESPEN. 2018;23:222-227. doi:10.1016/j.clnesp.2017.09.010
  • 12. Kjaergaard M, Eggen AE, Mathiesen EB, et al. Association between headache and serum 25-hydroxyvitamin D: the Tromsø Study: Tromsø 6. Headache. 2012;52(10):1499-1505. doi:10.1111/j.1526-4610.2012.02250.x
  • 13. Zandifar A, Masjedi SS, Banihashemi M, et al. Vitamin D status in migraine patients: a case-control study. Biomed Res Int. 2014;2014:514782. doi:10.1155/2014/514782
  • 14. Vuković-Cvetković V, Plavec D, Lovrencić-Huzjan A, et al. Is iron deficiency anemia related to menstrual migraine? Post hoc analysis of an observational study evaluating clinical characteristics of patients with menstrual migraine. Acta Clin Croat. 2010;49(4):389-394.
  • 15. Fallah R, Zare Bidoki S, Ordooei M. Evaluation Efficacy of Ferrous Sulfate Therapy on Headaches of 5-15 Years Old Iron Deficient Children with Migraine. Iran J Ped Hematol Oncol. 2016;6(1):32-37.
  • 16. Gür-Özmen S, Karahan-Özcan R. Iron Deficiency Anemia Is Associated with Menstrual Migraine: A Case-Control Study. Pain Med. 2016;17(3):596-605. doi:10.1093/pm/pnv029
  • 17. Demirel H, Emre U, Atasoy HT ve ark. Migren ve epizodik gerilim tipi baş ağrıları ile hematolojik parametrelerin ilişkisi. Türk Nöroloji Dergisi 2008; 14(6):394-398.
  • 18. Acar A, Evliyaoğlu O, Uzar E ve ark. Migren hastalarında serum vitamin B12, folik asit ve ferritin düzeyleri. Turk Norol Derg 2011;17: 90-95.
  • 19. Nelson KB, Richardson AK, He J, et al. Headache and biomarkers predictive of vascular disease in a representative sample of US children. Arch Pediatr Adolesc Med. 2010;164(4):358-362. doi:10.1001/archpediatrics.2010.17
  • 20. Bottini F, Celle ME, Calevo MG, et al. Metabolic and genetic risk factors for migraine in children. Cephalalgia. 2006;26(6):731-737. doi:10.1111/j.1468-2982.2006.01107.x
  • 21. Lea R, Colson N, Quinlan S, et al. The effects of vitamin supplementation and MTHFR (C677T) genotype on homocysteine-lowering and migraine disability. Pharmacogenet Genomics. 2009;19(6):422-428. doi:10.1097/FPC.0b013e32832af5a3
  • 22. Menon S, Lea RA, Roy B, et al. Genotypes of the MTHFR C677T and MTRR A66G genes act independently to reduce migraine disability in response to vitamin supplementation. Pharmacogenet Genomics. 2012;22(10):741-749. doi:10.1097/FPC.0b013e3283576b6b
Toplam 22 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri (Diğer)
Bölüm Makaleler
Yazarlar

Gül Yücel 0000-0001-5753-9048

Yayımlanma Tarihi 31 Aralık 2023
Kabul Tarihi 15 Eylül 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 6 Sayı: 3

Kaynak Göster

APA Yücel, G. (2023). The role of serum ferritin, vitamin B12 and vitamin D levels in childhood primary headaches. Journal of Cukurova Anesthesia and Surgical Sciences, 6(3), 411-415. https://doi.org/10.36516/jocass.1356182
https://dergipark.org.tr/tr/download/journal-file/11303