Klinik Araştırma
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Subjektif Göz Şikayetleri Olan Hastalarda Kornea Analizi; Yeni Tanılı Prediyabetik Hastalar

Yıl 2025, Cilt: 8 Sayı: 3, 281 - 284, 30.09.2025

Öz

Giriş: Görme kalitesinde azalma benzeri subjektif şikayetler ile başvuran prediyabetik hastalarda olası korneal değişikliklerinin saptanması amaçlanmıştır.
Materyaller ve Yöntemler: Çalışmaya subjektif görme şikayetleri olan, herhangi bir optik sinir ve retina patolojisi saptanmayan, emetropik, travma öyküsü olmayan yeni tanılı 56 prediyabetik hasta ve 70 sağlıklı katılımcı dahil edilmiştir. Tüm hastaların detaylı ön segment ve muayeneleri sonrasında Scheimpflug Sirius® cihazı ile korneal topografi değerlendirilmesi yapılmış ve HbA1c değerleri ile karşılaştırılmıştır.
Results: Prediyabetik grupta yer alan hastaların yaş ortalaması 57,23 ± 8.1 yıl iken, kontrol grubundaki hastaların 60,58±6.74 yıl idi. (p>0,05). CCT değerleri prediyabetik grupta 550,00 µ ±45,00, kontrol grubunda ise 553,00 µ± 38 olarak saptandı. MCT prediyabetik grupta 518,00±41,00 µ, kontrol grubunda 533,00±33,00 µ olarak saptandı. Korneal dasitometri değerleri prediyabetik grupta 23,47±2,36 GSU iken kontrol grubunda ise 21,76±3,22 GSU olarak bulundu (p=<0.001). Grupların ortalama HbAc1 değerleri prediyabetik grupta 6,30±1,10 kontrol grubunda ise 5,20±0,20 idi. Ortalama kan şekeri değerleri ise prediyabetik grupta 109±26 ve kontrol grubunda 91±8 olarak saptandı. Korneanın refraktif değerleri ise sırasıyla prediyabetik grupta K1 değerleri 43,16 D±1,36 kontrol grubunda 42,38 D±1,38, K2 değerleri 44,15 D±1,50 kontrol grubunda 43,66 D±1,51 idi. HbA1c değerleri artıkça korneal dansitometri değerlerinin arttığı görülürken yapılan istatistiksel değerlendirmede iki değer arasında pozitif yönde korelasyon saptandı (r=.279**, p=0,002)
Sonuç: Prediyabetik durumun korneal dansitometri üzerindeki etkileri ve korneanın kalınlığı için olumsuz bir faktör olarak kabul edilmelidir. Subjektif görme şikayeti olan ve rekraftif değişiklik saptanmayan kişilerde prediyabetik durum b ve buna bağlı korneal değişiklikler olabilme ihtimali göz önünde bulundurulmalıdır.
Keywords: Prediyabet, Korneal Dansitometri, HbA1c

Kaynakça

  • 1.Ashraf S, Tahir A, Shabbir A, Awais M, Ali A, Shahzadi R, et al. Epidemiology of prediabetes and its diagnosis and treatment: a review. Biological and Clinical Sciences Research Journal. 2023;2023(1):616. [Crossref]
  • 2.Tabák Á, Herder C, Rathmann W, Brunner E, Kivimäki M. Prediabetes: a high-risk state for diabetes development. Lancet. 2012;379(9833):2279–90. [Crossref]
  • 3.Kalbani S. The effect of metformin in treating prediabetic patients. Interventions in Obesity & Diabetes. 2022;5(5). [Crossref]
  • 4.Rooney MR, Fang M, Ogurtsova K, Ozkan B, Echouffo-Tcheugui JB, Boyko EJ, et al. Global prevalence of prediabetes. Diabetes Care. 2023;46(7):1388–94. [Crossref]
  • 5.Sune M, Sune M, Sune P, Dhok A. Prevalence of retinopathy in prediabetic populations: a systematic review and meta-analysis. Cureus. 2023. [Crossref]
  • 6.Kirthi V, Nderitu P, Alam U, Evans J, Nevitt S, Malik R, et al. The prevalence of retinopathy in prediabetes: a systematic review. Surv Ophthalmol. 2022;67(5):1332–45. [Crossref]
  • 7.Wang T, Kuang L, Yao X, Gan R, Chen Q, Yan X. Association between prediabetes/hyperglycemia and retinal diseases: a meta-analysis. Eur J Ophthalmol. 2023;33(4):1687–96. [Crossref]
  • 8.Sawy S, Bekhit M, Abdelhamid A, Esmat S, Ashraf H, Naguib M. Assessment of early macular microangiopathy in subjects with prediabetes using OCT angiography and fundus photography. Acta Diabetol. 2024;61(1):69–77. [Crossref]
  • 9.El-Agamy A, Alsubaie SJ. Corneal endothelium and central corneal thickness changes in type 2 diabetes mellitus. Clin Ophthalmol. 2017:481–6. [Crossref]
  • 10.Cavas F, Sánchez EdlC, Martínez JN, Cañavate FJF, Fernández-Pacheco DG. Corneal topography in keratoconus: state of the art. Eye Vis. 2016;3(1). [Crossref]
  • 11.Eraslan N, Ekici E, Çelikay O. The effect of topical bimatoprost on corneal clarity in primary open-angle glaucoma: a longitudinal prospective assessment. Int Ophthalmol. 2021;42(3):731–8. [Crossref]
  • 12.Olyntho MA, Augusto LB, Gracitelli CPB, Tatham AJ. The effect of corneal thickness, densitometry and curvature on intraocular pressure measurements obtained by applanation, rebound and dynamic contour tonometry. Vision. 2020;4(4):45. [Crossref]
  • 13.American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2014;37 Suppl 1:S81–90. [Crossref]
  • 14.Gutierrez R, Lopez I, Villa-Collar C, et al. Corneal transparency after cross-linking for keratoconus: 1-year follow-up. J Refract Surg. 2012;28(11):781–5. [Crossref]
  • 15.Alakuş MF, Çağlayan M, Ekin N, Öncül H, Araç E, Dağ U, et al. Investigation of corneal topographic and densitometric properties of Wilson’s disease patients with or without a Kayser-Fleischer ring. Eye Vis. 2021;8(1). [Crossref]
  • 16.Gao Y, Yang N, Wei L, Yan Y, Li L. Relationship between postoperative oxidative stress levels and corneal endothelial cell loss after phacoemulsification in diabetic patients with cataract. Clin Ophthalmol. 2024;18:3957–65. [Crossref]
  • 17.Pandey S, Mishra D, Singh TB, Tiwari P, Manisha, Ekagrata, et al. Correlation of glycosylated hemoglobin (HbA1c) with retinal nerve fiber layer thickness and central macular thickness in the diabetic population in North India. Indian J Ophthalmol. 2024;72(8):1186–91. [Crossref]
  • 18.Módis L Jr, Szalai E, Kertész K, Kemény-Beke A, Kettesy B, Berta A. Evaluation of the corneal endothelium in patients with diabetes mellitus type I and II. Histol Histopathol. 2010;25(12):1531–7.
  • 19.Hatou S, Yamada M, Akune Y. Role of insulin in regulation of Na+/K+-dependent ATPase activity and pump function in corneal endothelial cells. Invest Ophthalmol Vis Sci. 2010;51(8):3935. [Crossref]
  • 20.Elagamy A, Abaalhassan N, Berika M. Evaluation of corneal backward light scattering in type 2 diabetes mellitus. Int J Ophthalmol. 2023;16(10):1636–41. [Crossref]
  • 21.Narooie-Noori F, Mirzajani A, Jafarzadehpur E, Behnia M, Khabazkhoob M. Comparison of anterior segment parameters of the eye between type 2 diabetic patients with and without diabetic retinopathy and non-diabetic individuals. Int J Ophthalmol. 2023;16(4):571–8. [Crossref]
  • 22.Recent evidence that corneal changes may precede retinal alterations in prediabetes. Invest Ophthalmol Vis Sci. 2024.
  • 23.Huseynova T, Galbinur T, Abdullayev A, Rahimzade A. Corneal measurements in patients with diabetes mellitus. Azerbaijan Med Assoc J. 2016;1(2):59. [Crossref]
  • 24.Yilmaz YC, Hayat SC, Ipek SC. Analysis of Corneal and Lens Densitometry Changes in Patients With Type 1 Diabetes Mellitus. Am J Ophthalmol. 2023 Oct;254:23–30. [Crossref]
  • 25.Moezzi A, Varikooty J, Schulze M, Ngo W, Lorenz KO, Boree D, et al. Corneal swelling with cosmetic etafilcon A lenses versus no lens wear. Optom Vis Sci. 2016;93(6):619–28. [Crossref]
  • 26.Edelhauser HF. The balance between corneal transparency and edema. Invest Ophthalmol Vis Sci. 2006;47(5):1755–67. [Crossref]

Corneal Analysis in Patients Presenting with Subjective Eye Complaints; Newly Diagnosed Prediabetic Patients

Yıl 2025, Cilt: 8 Sayı: 3, 281 - 284, 30.09.2025

Öz

Introduction: Subjective symptoms such as decreased visual quality The aim of this study was to detect possible corneal changes in prediabetic patients presenting with complaints .
Materials and Methods: The study included 56 newly diagnosed prediabetic patients with subjective visual complaints, no optic nerve and retina pathology, emmetropic , no history of trauma , and 70 healthy participants. After detailed anterior segment and Corneal with Sirius ® device Topography was evaluated and compared with HbA1c values.
Results : The mean age of the patients in the prediabetic group was 57.23 ± 8.1 years, while the mean age of the patients in the control group was 60.58±6.74 years (p>0.05). CCT values were 550.00 µ ± 45.00 in the prediabetic group and 553.00 µ± 38 in the control group. MCT was 518.00± 41.00 µ in the prediabetic group and 533.00± 33.00 µ in the control group. Corneal The mean HbAc1 values of the groups were 6.30 ±1.10 in the prediabetic group and 5.20±0.20 in the control group. The mean blood sugar values were 109±26 in the prediabetic group and 91±8 in the control group. The refractive values of the cornea were 43.16 D±1.36 in the prediabetic group, 42.38 D±1.38 in the control group, and 44.15 D±1.50 in the control group, and 43.66 D±1.51 in the control group, respectively . As the HbA1c values increased, the corneal While it was observed that the densitometry values increased, a positive correlation was found between the two values in the statistical evaluation (r=.279**, p=0.002).
Conclusion: Prediabetic status is associated with corneal effects on densitometry and should be considered as a negative factor for the thickness of the cornea. In individuals with subjective visual complaints and no refractive changes, the possibility of prediabetic status b and related corneal changes should be taken into consideration.

Etik Beyan

Erzurum Tıp Fakültesi BAEK 2025/06-160 Karar nolu Retrospektif Araştırma, Amaç, gerekçe, yaklaşım ve yöntemle ilgili açıklamaları, Bilimsel Araştırmalar Etik Kurulu yönergesine göre incelenmiş etik açıdan bir sakınca olmadığına 14.05.2025 tarihli etik kurulunca birliği ile karar verilmiştir.

Kaynakça

  • 1.Ashraf S, Tahir A, Shabbir A, Awais M, Ali A, Shahzadi R, et al. Epidemiology of prediabetes and its diagnosis and treatment: a review. Biological and Clinical Sciences Research Journal. 2023;2023(1):616. [Crossref]
  • 2.Tabák Á, Herder C, Rathmann W, Brunner E, Kivimäki M. Prediabetes: a high-risk state for diabetes development. Lancet. 2012;379(9833):2279–90. [Crossref]
  • 3.Kalbani S. The effect of metformin in treating prediabetic patients. Interventions in Obesity & Diabetes. 2022;5(5). [Crossref]
  • 4.Rooney MR, Fang M, Ogurtsova K, Ozkan B, Echouffo-Tcheugui JB, Boyko EJ, et al. Global prevalence of prediabetes. Diabetes Care. 2023;46(7):1388–94. [Crossref]
  • 5.Sune M, Sune M, Sune P, Dhok A. Prevalence of retinopathy in prediabetic populations: a systematic review and meta-analysis. Cureus. 2023. [Crossref]
  • 6.Kirthi V, Nderitu P, Alam U, Evans J, Nevitt S, Malik R, et al. The prevalence of retinopathy in prediabetes: a systematic review. Surv Ophthalmol. 2022;67(5):1332–45. [Crossref]
  • 7.Wang T, Kuang L, Yao X, Gan R, Chen Q, Yan X. Association between prediabetes/hyperglycemia and retinal diseases: a meta-analysis. Eur J Ophthalmol. 2023;33(4):1687–96. [Crossref]
  • 8.Sawy S, Bekhit M, Abdelhamid A, Esmat S, Ashraf H, Naguib M. Assessment of early macular microangiopathy in subjects with prediabetes using OCT angiography and fundus photography. Acta Diabetol. 2024;61(1):69–77. [Crossref]
  • 9.El-Agamy A, Alsubaie SJ. Corneal endothelium and central corneal thickness changes in type 2 diabetes mellitus. Clin Ophthalmol. 2017:481–6. [Crossref]
  • 10.Cavas F, Sánchez EdlC, Martínez JN, Cañavate FJF, Fernández-Pacheco DG. Corneal topography in keratoconus: state of the art. Eye Vis. 2016;3(1). [Crossref]
  • 11.Eraslan N, Ekici E, Çelikay O. The effect of topical bimatoprost on corneal clarity in primary open-angle glaucoma: a longitudinal prospective assessment. Int Ophthalmol. 2021;42(3):731–8. [Crossref]
  • 12.Olyntho MA, Augusto LB, Gracitelli CPB, Tatham AJ. The effect of corneal thickness, densitometry and curvature on intraocular pressure measurements obtained by applanation, rebound and dynamic contour tonometry. Vision. 2020;4(4):45. [Crossref]
  • 13.American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2014;37 Suppl 1:S81–90. [Crossref]
  • 14.Gutierrez R, Lopez I, Villa-Collar C, et al. Corneal transparency after cross-linking for keratoconus: 1-year follow-up. J Refract Surg. 2012;28(11):781–5. [Crossref]
  • 15.Alakuş MF, Çağlayan M, Ekin N, Öncül H, Araç E, Dağ U, et al. Investigation of corneal topographic and densitometric properties of Wilson’s disease patients with or without a Kayser-Fleischer ring. Eye Vis. 2021;8(1). [Crossref]
  • 16.Gao Y, Yang N, Wei L, Yan Y, Li L. Relationship between postoperative oxidative stress levels and corneal endothelial cell loss after phacoemulsification in diabetic patients with cataract. Clin Ophthalmol. 2024;18:3957–65. [Crossref]
  • 17.Pandey S, Mishra D, Singh TB, Tiwari P, Manisha, Ekagrata, et al. Correlation of glycosylated hemoglobin (HbA1c) with retinal nerve fiber layer thickness and central macular thickness in the diabetic population in North India. Indian J Ophthalmol. 2024;72(8):1186–91. [Crossref]
  • 18.Módis L Jr, Szalai E, Kertész K, Kemény-Beke A, Kettesy B, Berta A. Evaluation of the corneal endothelium in patients with diabetes mellitus type I and II. Histol Histopathol. 2010;25(12):1531–7.
  • 19.Hatou S, Yamada M, Akune Y. Role of insulin in regulation of Na+/K+-dependent ATPase activity and pump function in corneal endothelial cells. Invest Ophthalmol Vis Sci. 2010;51(8):3935. [Crossref]
  • 20.Elagamy A, Abaalhassan N, Berika M. Evaluation of corneal backward light scattering in type 2 diabetes mellitus. Int J Ophthalmol. 2023;16(10):1636–41. [Crossref]
  • 21.Narooie-Noori F, Mirzajani A, Jafarzadehpur E, Behnia M, Khabazkhoob M. Comparison of anterior segment parameters of the eye between type 2 diabetic patients with and without diabetic retinopathy and non-diabetic individuals. Int J Ophthalmol. 2023;16(4):571–8. [Crossref]
  • 22.Recent evidence that corneal changes may precede retinal alterations in prediabetes. Invest Ophthalmol Vis Sci. 2024.
  • 23.Huseynova T, Galbinur T, Abdullayev A, Rahimzade A. Corneal measurements in patients with diabetes mellitus. Azerbaijan Med Assoc J. 2016;1(2):59. [Crossref]
  • 24.Yilmaz YC, Hayat SC, Ipek SC. Analysis of Corneal and Lens Densitometry Changes in Patients With Type 1 Diabetes Mellitus. Am J Ophthalmol. 2023 Oct;254:23–30. [Crossref]
  • 25.Moezzi A, Varikooty J, Schulze M, Ngo W, Lorenz KO, Boree D, et al. Corneal swelling with cosmetic etafilcon A lenses versus no lens wear. Optom Vis Sci. 2016;93(6):619–28. [Crossref]
  • 26.Edelhauser HF. The balance between corneal transparency and edema. Invest Ophthalmol Vis Sci. 2006;47(5):1755–67. [Crossref]
Toplam 26 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Cerrahi (Diğer)
Bölüm Makaleler
Yazarlar

Bahadır Utlu 0000-0002-7129-2181

Yunus Emre Erat 0009-0004-7579-2003

Yayımlanma Tarihi 30 Eylül 2025
Gönderilme Tarihi 15 Mayıs 2025
Kabul Tarihi 29 Eylül 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 8 Sayı: 3

Kaynak Göster

APA Utlu, B., & Erat, Y. E. (2025). Corneal Analysis in Patients Presenting with Subjective Eye Complaints; Newly Diagnosed Prediabetic Patients. Journal of Cukurova Anesthesia and Surgical Sciences, 8(3), 281-284.
https://dergipark.org.tr/tr/download/journal-file/11303