Prognosis in head and neck cancer: the importance of the patient-, and treatment-related factors

Abstract

Objective: To investigate the importance of comorbidity, performance status, hemoglobin level, weight loss, interruption of radiotherapy, and mucositis as prognostic factors in head and neck cancer patients. Methods: Two-hundred and ten patients who were admitted to the Oncology Center of our university between 2006 and 2012, and treated for head and neck cancer were included in the study. Performance status at admission was evaluated according to Eastern Cooperative Oncology Group (ECOG) scoring system. Staging of the disease was based on TNM staging system revised in 2010. Results: The median follow-up period was 24 (range: 1-134) months. Recurrence was observed in 24% of the patients in a median 11 (range: 3-96) months. Metastasis was observed in 13% of patients, in the median 15 (range: 1-134 months). The 3-year local control, overall survival and disease-free survival rates were 72%, 59%, and 53%, respectively for all patients. The factors affecting the 3-year local control rates in univariate analysis were performance status (p=0.006), weight loss (p=0.002), localization (p=0.003), and stage (p

Keywords

• Head and neck cancer, weight loss, hemoglobin

Baş boyun kanserlerinde prognoz: Hasta ve tedaviyle ilişkili faktörlerin önemi

Öz

Amaç: Bu çalışmanın amacı baş boyun kanserinde prognostik faktör olarak komorbidite, performans durumu, hemoglobin düzeyi, kilo kaybı, radyoterapiye ara verme ve mukozitin öneminin araştırılmasıdır. Yöntem: Üniversitesimizin Onkoloji Merkezine 2006 ve 2012 tarihleri arasında, baş boyun kanseri tanısı ile tedavi edilen 210 hastanın verileri incelendi. Hastaların performans durumu, hasta başvurusunda Eastern Cooperative Oncology Group (ECOG) skorlama sistemine göre değerlendirildi. Hastalık evresi 2010'da revize edilen TNM evrelemesine göre yapıldı. Bulgular: Hastalar, medyan 24 (dağılım: 1-134) ay takip edildi. Medyan 11 (dağılım: 3-96) ayda hastaların %24'ünde nüks gelişirken, medyan 15 (dağılım: 1-134) ayda %13'ünde uzak metastaz gelişti. Tüm hastalar için 3 yıllık lokal kontrol %72, 3 yıllık genel sağkalım %59, 3 yıllık hastalıksız sağkalım %53 idi. Tek değişkenli analizde hastaların lokal kontrol oranlarını performans durumu (p=0.006), kilo kaybı (p=0.002), hastalık lokalizasyonu (p=0.003), evre (p

Anahtar Kelimeler

• Baş boyun kanseri, kilo kaybı, hemoglobin

Kaynakça

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37. Please cite this article as: Yücel B, Eren MF, Akkafl Atesever E, Kaçan T, Hasbek Z, Şeker MM. Prognosis in head and neck cancer: the importance
38. of the patient-, and treatment-related factors. J Med Updates 2013;3(3):109-115.