Total antioxidant capacity, total oxidant level and oxidative stress index in patients with laryngopharyngeal reflux with Helicobacter pylori IGG positivity

Abstract

Objective: The aim of this study is to investigated the relationship between H. pylori IgG positivity, total antioxidant capacity (TAC), total oxidant level (TOL) and oxidative stress index (OSI) in patients with laryngopharyngeal reflux (LPR). Methods: A total of 48 patients with laryngopharyngeal reflux (LPR) were included into the study group. Of these patients, 20 with H. pylori IgG (-), LPR (+) were included into Group 2; and 28 patients with H. pylori IgG (+), LPR (+) were included into Group 3. The control group (Group 1) consisted of 19 healthy subjects. In all groups, total antioxidant capacity, total oxidant level and oxidative stress index were studied. Results: Group 3's total oxidant level values were significantly higher than those of Group 1 (p=0.000) and Group 2 (p=0.000); and Group 2's total oxidant level values were significantly higher than Group 1. Group 3's oxidative stress index values were significantly higher than those of Group 1 (p=0.000) and Group 2 (p=0.000), and Group 2's oxidative stress index values were significantly higher than Group 1 (p=0.001). Conclusion: The presence of LFR alone, or LFR and increase in the level of serum IgG antibody developed against H. pylori, lead to increase in total oxidant level and oxidative stress index. Both LPR and to be infected with H. pylori and development of H. pylori IgG antibodies lead to an increase in total oxidant level and oxidative stress index; and an increase in free radicals ultimately lead to an increase in oxidative stress in the body.

Keywords

• Helicobacter pylori, total antioxidant capacity, total oxidant level, oxidative stress index

Helicobacter pylori serum IGG'si pozitif olan larengofarengeal reflülü olgularda total antioksidan kapasite, total oksidan seviye ve oksidatif stres indeksi

Öz

Amaç: Bu çalışmanın amacı, larengofarengeal reflü (LFR) hastalarında, H. pylori serum IgG pozitifliği, total antioksidan kapasite, total oksidan seviye ve oksidatif stres indeksi arasındaki ilişkiyi araştırmaktır. Yöntem: Larengofarengeal reflü (LFR) şikayeti ile başvuran 48 hasta çalışma grubuna alınmıştır. Bu hastalardan, H. pylori IgG (-), LFR (+) olan 20 hasta Grup 2 ve H. pylori IgG (+), LFR (+) olan 28 hasta Grup 3 olarak çalışmaya alınmıştır. Kontrol grubunu (Grup 1) ise, 19 sağlıklı birey oluşturmuştur. Tüm gruplarda, total antioksidan kapasite, total oksidan seviye ve oksidatif stres indeksi çalışılmıştır. Bulgular: Grup 3'ün total oksidan seviye değerleri, Grup 1 (p=0.000) ve Grup 2'den (p=0.000) ve Grup 2'nin total oksidan seviye değerleri ise, Grup 1'den istatistiksel olarak anlamlı şekilde daha yüksekti. Grup 3'ün oksidatif stres indeksi değerleri, Grup 1 (p=0.000) ve Grup 2'den (p=0.000), Grup 2'nin oksidatif stres indeksi değerleri, Grup 1'den (p=0.001) istatistiksel olarak anlamlı şekilde daha yüksekti. Sonuç: Tek başına LFR varlığı veya LFR ve H. pylori'ye karşı gelişen serum IgG antikor seviyesindeki artış, total oksidan seviye ve oksidatif stres indeksinde artmaya yol açmaktadır. Hem LFR hem de H. pylori ile enfekte olunması ve H. pylori'ye karşı IgG antikorlarının gelişmesi, vücutta total oksidan seviye ve oksidatif stres indeksinde artışa yol açarak, sonuçta serbest radikallerde artışa ve vücutta oksidatif streste artışa yol açmaktadır.

Anahtar Kelimeler

• Helicobacter pylori, total antioksidan kapasite, total oksidan seviye, oksidatif stres indeksi

Kaynakça

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26. Bu açık eriflim makalenin, ticari kullanım amacı ve içerik de¤iflikli¤i dıflında kalan ço¤altma, da¤ıtma vb. tüm kullanım hakları, bilinen standartlarda kay
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29. Makalenin atıf künyesi: Mutlu Ö, Kar M, Yıldız Zeyrek F, Aksoy N, Taflkın A. Helicobacter pylori serum IGG’si pozitif olan larengofarengeal reflülü olgu
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