Prognostic Signifi cance Of Body Composition Analysis Measurements In Patients With Locally Advanced Or Metastatic Cancers

Yıl 2015, , - , 20.06.2015

Cemil Bilir Huseyin Engin Selcuk Ergen Yasemin Bakkal Temi Hasan Morcalı

https://doi.org/10.1093/annonc/

Öz

Objectives: There are many parameters in the body composition analyses and Bio-impedance analysis (BIA) measurements such as total weight, body fat (BF%), fat-free mass (FFM), muscle mass, metabolic age, basal metabolic rate, resistance and phase angle. But we do not well known which of the parameter is the most important or which one of them are associated with overall survival (OS). Material and Method: In total, 173 patients have included in the study. Results: The mean age 54 years in man and 51 years in woman. Patients with cancer had lower hemoglobin and albumin levels compared to the healthy controls. The median OS was 17 months of the cancer group and women were alive longer than men (22 vs 13 months, p<0.001). Multivariate analysis revealed that, BF% (HR, 0.8, 95% CI, 0.75-0.87, r=35.8, P<0.001), total body water (TBW%) (HR, 0.89, 95% CI, 0.82-0.97, r=7.8, P=0.035), BMI (HR, 0.83, 95% CI, 0.740.93, r=13.9, P=0.003) were found to be statically signiŞ cantly associated with OS.Conclusion: Present study showed that, increased BMI, fat mass and total body water at the time of diagnosis of cancer, are good prognostic factors in patients with metastatic disease. Gender did not have any impact on relation of BIA parameters with survival

Anahtar Kelimeler

Bio-impedance analysis, metastasis, cancer, survival

Prognostic Signifi cance Of Body Composition Analysis Measurements In Patients With Locally Advanced Or Metastatic Cancers

Öz

Amaç: Biyoimpedans analizinde (BIA) ölçülen bir çok parametre mevcuttur;total vücut ağırlığı (TVA),vücut yağı (%VY), Yağsız vücut kütlesi (%YVK), Kas kütlesi, metabolizma yaşı, bazal metabolzma hızı, rezistans ve faz açısı gibi. Ama bu parametrelerden hangisinin daha önemli olduğu ve yaşam süresi ile ilişkili olduğu tam olarak bilinmemektedir. Gereç ve Yöntem: Toplamda 173 hasta çalışmaya dahil edildi.Bulgular: Ortanca yaş erkeklerde 54, kadınlarda 51’ di. Kanser hastalarında kontrol grubuna göre daha düşük hemoglobulin ve albumin düzeyleri mevcuttu. Ortanca sağ kalım süresi kanser grubunda 17 aydı ve kadınların yaşam süresi erkeklere göre anlamlı olarak daha uzun bulundu (22 aya karşın 13 ay, P<0.001). Multivaryant analize göre %VY (HR, 0.8, 95% CI, 0.75-0.87, r=35.8, P<0.001), total vücut suyu (%TVS) (HR, 0.89, 95% CI, 0.82-0.97, r=7.8, P=0.035) ve vücut kütle indeksi (VKI) (HR, 0.83, 95% CI, 0.74-0.93, r=13.9, P=0.003) genel sağkalımla anlamlı olarak ilişkili saptandı.Sonuç: Güncel çalışma gösterdiki artmış VKI, yağ kütlesi ve total vücut suyu kanser tanısı konulduğu anda metastatik hastalar için iyi prognostik bir bulgudur. Cinsiyetin BIA parametreleri ve sağkalıma ek bir katkısının olmadığı gösterildi

Anahtar Kelimeler

Biyoo-impedans analizi, metastaz, kanser, survival

Kaynakça

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