Colon Adenocarcinoma With Orbital Metastasis

Abstract

Orbital metastasis in solid tumors, especially in colon adenocarcinomas, is very rare and its management is a real challenge in clinical oncology. Here, we report a 60-year-old woman with stage IV colon adenocarcinoma, who was admitted with ophthalmic complaints while under systemic chemotherapy. The patient had conjunctival chemosis, severe exophthalmos,
ptosis, and limitation of movement on the left eye. Magnetic resonance imaging revealed a 35x21 mm soft tissue mass in the left orbita. The patient refused further treatment and was released in 15 days. The treatment of metastatic orbital tumors is often multidisciplinary; combining local treatments (surgery and radiotherapy), systemic treatments (chemotherapy, biological and hormonal therapies), and palliative approaches (mainly based on corticosteroids) together. The disease has poor prognosis due to dissemination of the systemic cancer.

Keywords

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Colon Adenocarcinoma With Orbital Metastasis

Öz

Orbital metastaz tüm solid tümörlerde, özellikle de kolon adenokarsinomunda oldukça nadir bir durumdur ve yönetimi klinik onkolojide gerçek bir sorundur. Biz bu yazıda 60 yaşında, evre IV kolon adenokarsinomu tanısı olan ve sistemik kemoterapi altında oftalmik şikayetler ile başvuran kadın hastayı bildiriyoruz. Hastanın sol gözünde konjonktival kemozis,
şiddetli egzoftalmi, pitozis ve hareket kısıtlılığı vardı. Manyetik rezonans görüntüleme sol orbita bir 35x21 mm’lik yumuşak doku kitlesi saptandı. Sunulan olgu ileri tedaviyi reddetti ve 15 gün içinde eksitus oldu. Orbital metastatik tümörlerin tedavisi; lokal tedaviler (cerrahi ve radyoterapi), sistemik tedaviler (kemoterapi, biyolojik ve hormonal tedaviler) ve palyatif yöntemlerin (kortikosteroid temelli tedaviler) birlikte katılımı ile multidisipliner olarak yapılmalıdır ancak hastalığın yaygın
hale gelmiş olması sebebiyle hastalık kötü prognozludur.

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