Kan Yoluyla Bulaşan Farklı Bir Viral Etken; Pegivirus

Abstract

İnsan Pegivirüsü (HPgV; eskiden GB virus C/hepatitis G virus olarak adlandırılmıştır) Flaviviridae ailesi  içerisinde sınıflandırılan bir RNA virüsüdür. HPgV, Hepatit C virüsüne (HCV) benzer şekilde tek sarmal pozitif iplikçikli RNA genomuna sahiptir. Dünya genelinde 750 milyon kişinim aktif olarak enfekte olduğu, 750 milyon-1.5 milyar arasında kişinin ise enfeksiyondan etkilenmiş olduğu tahmin edilmektedir. Karaciğer biyopsilerinde HPgV RNA’sı saptanmış olmakla birlikte hepatitle ilişkisi bulunmamıştır. Dalak, kemik iliği, serebraspinal sıvısı (CSF), PBMC, T ve B lenfositlerde de virüs saptanmıştır. Persistan enfeksiyonların %25’i kalıcı hale gelmekte,  %75’inde ise enfeksiyonun 2 yılı içinde viremi sonlanmaktadır. Ayrıca HPgV viremisinin oranı, kanla ya da cinsel yolla bulaşan enfeksiyonlara sahip insanlar arasında daha yüksektir. HPgV bulaşı, enfekte kana maruziyet, cinsel maruziyet veya anneden bebeğe geçiş ile olmaktadır. HPgV’nin herhangi bir insan hastalığı nedeni olduğu kanıtlanmamış olmasına rağmen; bazı çalışmalarda HPgV viremisi ile non-Hodgkin lenfoma riskinin artışı arasında bir ilişki olduğu gözlemlenmiştir. Bu derlemede HPgV ile ilgili mevcut verilerin gözden geçirilmesi amaçlanmıştır.

Keywords

• Pegivirus,Hepatit

Kaynakça

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