Mikrobiata ve Kronik Hastalıklar

Abstract

Vücudumuzda mikrobiata adı verilen çok sayıda kommensal ve mutual mikroorganizma mevcuttur. Kendi mikrobial florası olan başlıca sistemler gastrointestinal sistem, genitoüriner sistem ve solunum sistemi ve deridir. Özellikle barsak mikrobiata denilen gastrointestinal sistem florasının, son zamanlarda bir çok fizyolojik ve patolojik süreçte önemi fark edilmiştir.

Barsak mikrobatası ile ilgili ilk çalışmalar rekürren C. Difficile enfeksiyonunun tedavisi için planlanmıştır. Barsak mikrobiota modulasyonu ile rekürren C. Difficile enfeksiyonunun tedavisinde sağlanan büyük başarı ile birlikte barsak mikrobatası birçok gastrointestinal ve extragastrointestinal kronik hastalıkta çalışılmış ve önemi anlaşılmıştır.Bu yüzden şu anda barsak mikrobata modulasyonu ve değişimi ile bir çok hastalık tedavi edilmeye çalışılmaktadır.

İntestinal mikrobiota gelecekte birçok kronik hastalığın tedavisinde büyük umut vaad etmektedir. Ancak daha kapsamlı çalışmalara ciddiyetle ihtiyaç vardır. Biz bu derlemede çeşitli kronik hastalıklar ile intestinal mikrobiata arasındaki ilişkiyi inceledik.

Keywords

• kronik hastalık,mikrobiata,barsak florası

Kaynakça

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