Relationship Between Bilirubin Levels and Heart Rate Recovery in Polycystic Ovary Syndrome Patients

Abstract

Aim: Bilirubin is a final product of heme metabolism 

and also has antioxidant properties. But there is no 

information on the effect of bilirubin in the 

pathogenesis of in Polycystic Ovary Syndrome 

(PCOS). The goal of the present study was to 

investigate the relationship between bilirubin levels, 

PCOS and heart rate recovery (HRR).  

Material and Methods: Subjects were included in 

this study from our center’s Department of 

Gynecology & Obstetrics between March 2012 and 

May 2013. Serum bilirubin levels and other blood 

parameters in at least 12-hour fasting states were 

determined. Exercise stress test was performed on all 

patients and control participants

Results: Thirty four patients with a diagnosis of 

PCOS aged younger than 40 year and twenty seven 

healthy women matched by age, BMI, heart rate and 

blood pressure were included in the study. Total 

bilirubin levels in PCOS group were significantly 

lower than the control group. The HRR was 

significantly decreased in women with PCOS 

compared the control group. In the Pearson 

correlation test, HRR was significantly correlated 

with homeostasis model assessment insulin resistance 

(HOMA-IR) index and bilirubin levels. 

Conclusions:  The bilirubin levels may affect HRR in 

PCOS patients. Therefore, in the treatment of PCOS 

patients, oxidative stress and its harmful effects 

should be considered. 

Keywords

• Bilirubin,heart rate recovery,polycystic ovary syndrome,exercise test

Kaynakça

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