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Stiff Person Syndrome in A Patient With Pancreatic Adenocarcinoma: An Unusual Paraneoplastic Syndrome

Yıl 2015, Cilt: 1 Sayı: 3, 123 - 126, 18.12.2015

E. Nayır M.b. Koyuncu S. Erdogdu A. Ata İ.a. Yılmaz A. Arıcan

Öz

Stiff person syndrome(SPS) is a rare clinical condition which is characterized by progressive muscle stiffness, rigidity and muscle spasms which are worsened by emotional stres and some triggers. SPS has three variants : autoimmune, idiopathic and paraneoplastic. Paraneoplastic variant is associated with neoplasms. There is non-organ-spesifi c antibodies, but
not anti-GAD or anti-islet cell antibodies in circulation. Paraneoplastic variant was reported in patients with breast cancer and small cell lung cancer before. However, there is no report with pancreatic cancer at literature. We think that this case is the fi rst one showing the relation of SPS with pancreatic cancer.

Anahtar Kelimeler

Stiff person syndrome paraneoplastic pancreatic cancer

Kaynakça

  • Shaw PJ. Stiff-man syndrome and its variants. Lancet. 1999 Jan
  • ;353(9147):86-7.
  • Grimaldi LM, Martino G, Braghi S, Quattrini A, Furlan R, Bosi E, Comi G.
  • Heterogeneity of autoantibodies in stiff-man syndrome. Ann Neurol. 1993
  • Jul;34(1):57-64.
  • De Camilli P, Thomas A, Cofiell R, Folli F, Lichte B, Piccolo G, Meinck HM,
  • Austoni M, Fassetta G, Bottazzo G, Bates D, Cartlidge N, Solimena M,
  • Kilimann MW, et al. The synaptic vesicle-associated protein amphiphysin
  • is the 128-kD autoantigen ofStiff-Man syndrome with breast cancer. J Exp
  • Med. 1993 Dec 1;178(6):2219-23.
  • Stayer C, Meinck HM. Stiff-man syndrome: an overview. Neurologia. 1998
  • Feb;13(2):83-8.
  • Kimura, J.Electrodiagnosis is Diseases of Nerve and Muscle: Principles and
  • Practice, 2nd edition, FA Davis, Philadelphia, 1989.
  • Krishna VR, Knievel K, Ladha S, Sivakumar K. Lower extremity predominant
  • stiff-person syndrome and limbic encephalitis with amphiphysin antibodies
  • in breast cancer. J Clin Neuromuscul Dis. 2012 Dec;14(2):72-4.
  • Nguyen-Huu BK1, Urban PP, Schreckenberger M, Dieterich M, Werhahn KJ.
  • Antiamphiphysin-positive stiff-person syndrome associated with small cell
  • lung cancer. Mov Disord. 2006 Aug;21(8):1285-7.
  • Solimena M, Folli F, Aparisi R, Pozza G, De Camilli P. Autoantibodies to
  • GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome. N
  • Engl J Med. 1990 May 31;322(22):1555-60.

Stiff Person Syndrome in A Patient With Pancreatic Adenocarcinoma: An Unusual Paraneoplastic Syndrome

Yıl 2015, Cilt: 1 Sayı: 3, 123 - 126, 18.12.2015

E. Nayır M.b. Koyuncu S. Erdogdu A. Ata İ.a. Yılmaz A. Arıcan

Öz

Stiff person sendromu (SPS), progresif kas katılığı, rijiditesi ve kas spazmı ile giden, emosyonel stress ve bazı tetikleyici faktörlerle daha da kötüleşebilen nadir bir klinik durumdur. SPS’nin otoimmün, idiyopatik ve paraneoplastik olmak üzere üç varyantı vardır. Paraneoplastik tipi neoplaziler ile ilişkilidir. Paraneoplastik varyant, meme kanseri ve küçük hücreli akciğer kanserli hastalarda bildirilmiştir. Ancak literatürde pankreas kanseri ile ilişkisi bildirilmemiştir. Bu olgu sunumu ile pankreas kanserinin SPS ile ilişkisini ilk olarak gösterdiğimizi düşünmekteyiz.

Anahtar Kelimeler

Stiff person sendromu paraneoplastik pankreas kanseri

Kaynakça

  • Shaw PJ. Stiff-man syndrome and its variants. Lancet. 1999 Jan
  • ;353(9147):86-7.
  • Grimaldi LM, Martino G, Braghi S, Quattrini A, Furlan R, Bosi E, Comi G.
  • Heterogeneity of autoantibodies in stiff-man syndrome. Ann Neurol. 1993
  • Jul;34(1):57-64.
  • De Camilli P, Thomas A, Cofiell R, Folli F, Lichte B, Piccolo G, Meinck HM,
  • Austoni M, Fassetta G, Bottazzo G, Bates D, Cartlidge N, Solimena M,
  • Kilimann MW, et al. The synaptic vesicle-associated protein amphiphysin
  • is the 128-kD autoantigen ofStiff-Man syndrome with breast cancer. J Exp
  • Med. 1993 Dec 1;178(6):2219-23.
  • Stayer C, Meinck HM. Stiff-man syndrome: an overview. Neurologia. 1998
  • Feb;13(2):83-8.
  • Kimura, J.Electrodiagnosis is Diseases of Nerve and Muscle: Principles and
  • Practice, 2nd edition, FA Davis, Philadelphia, 1989.
  • Krishna VR, Knievel K, Ladha S, Sivakumar K. Lower extremity predominant
  • stiff-person syndrome and limbic encephalitis with amphiphysin antibodies
  • in breast cancer. J Clin Neuromuscul Dis. 2012 Dec;14(2):72-4.
  • Nguyen-Huu BK1, Urban PP, Schreckenberger M, Dieterich M, Werhahn KJ.
  • Antiamphiphysin-positive stiff-person syndrome associated with small cell
  • lung cancer. Mov Disord. 2006 Aug;21(8):1285-7.
  • Solimena M, Folli F, Aparisi R, Pozza G, De Camilli P. Autoantibodies to
  • GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome. N
  • Engl J Med. 1990 May 31;322(22):1555-60.
Toplam 23 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Makaleler
Yazarlar

E. Nayır Bu kişi benim

M.b. Koyuncu Bu kişi benim

S. Erdogdu Bu kişi benim

A. Ata Bu kişi benim

İ.a. Yılmaz Bu kişi benim

A. Arıcan Bu kişi benim

Yayımlanma Tarihi 18 Aralık 2015
Gönderilme Tarihi 18 Aralık 2015
Yayımlandığı Sayı Yıl 2015 Cilt: 1 Sayı: 3

Kaynak Göster

APA Nayır, E., Koyuncu, M., Erdogdu, S., Ata, A., vd. (2015). Stiff Person Syndrome in A Patient With Pancreatic Adenocarcinoma: An Unusual Paraneoplastic Syndrome. Journal of Human Rhythm, 1(3), 123-126.
AMA Nayır E, Koyuncu M, Erdogdu S, Ata A, Yılmaz İ, Arıcan A. Stiff Person Syndrome in A Patient With Pancreatic Adenocarcinoma: An Unusual Paraneoplastic Syndrome. Journal of Human Rhythm. Aralık 2015;1(3):123-126.
Chicago Nayır, E., M.b. Koyuncu, S. Erdogdu, A. Ata, İ.a. Yılmaz, ve A. Arıcan. “Stiff Person Syndrome in A Patient With Pancreatic Adenocarcinoma: An Unusual Paraneoplastic Syndrome”. Journal of Human Rhythm 1, sy. 3 (Aralık 2015): 123-26.
EndNote Nayır E, Koyuncu M, Erdogdu S, Ata A, Yılmaz İ, Arıcan A (01 Aralık 2015) Stiff Person Syndrome in A Patient With Pancreatic Adenocarcinoma: An Unusual Paraneoplastic Syndrome. Journal of Human Rhythm 1 3 123–126.
IEEE E. Nayır, M. Koyuncu, S. Erdogdu, A. Ata, İ. Yılmaz, ve A. Arıcan, “Stiff Person Syndrome in A Patient With Pancreatic Adenocarcinoma: An Unusual Paraneoplastic Syndrome”, Journal of Human Rhythm, c. 1, sy. 3, ss. 123–126, 2015.
ISNAD Nayır, E. vd. “Stiff Person Syndrome in A Patient With Pancreatic Adenocarcinoma: An Unusual Paraneoplastic Syndrome”. Journal of Human Rhythm 1/3 (Aralık 2015), 123-126.
JAMA Nayır E, Koyuncu M, Erdogdu S, Ata A, Yılmaz İ, Arıcan A. Stiff Person Syndrome in A Patient With Pancreatic Adenocarcinoma: An Unusual Paraneoplastic Syndrome. Journal of Human Rhythm. 2015;1:123–126.
MLA Nayır, E. vd. “Stiff Person Syndrome in A Patient With Pancreatic Adenocarcinoma: An Unusual Paraneoplastic Syndrome”. Journal of Human Rhythm, c. 1, sy. 3, 2015, ss. 123-6.
Vancouver Nayır E, Koyuncu M, Erdogdu S, Ata A, Yılmaz İ, Arıcan A. Stiff Person Syndrome in A Patient With Pancreatic Adenocarcinoma: An Unusual Paraneoplastic Syndrome. Journal of Human Rhythm. 2015;1(3):123-6.