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D Vitaminin Obezite, Diabetes Mellitus, Hipertansiyon ve Kanser İle İlişkisi

Yıl 2015, Cilt: 1 Sayı: 4, 143 - 149, 18.12.2015

Öz

D vitamini kalsiyum ve fosfor metabolizmasını düzenleyen, yağda eriyen vitaminler arasında yer alan ve diğer vitaminlerden farklı olarak vücutta üretilen hormon ve hormon öncüleri olan bir grup steroldür. D vitamininin sadece kemik, böbrek ve bağırsak üzerinde değil, aynı zamanda beyin, prostat, meme, kolon, pankreas, immün hücreler, kaslar, endotel ve miyokard olmak üzere pek çok organ üzerinde de etkisi olduğu belirtilmektedir. D vitamini pankreasta Beta hücreleri üzerinde stokinlerin neden olduğu hücre harabiyetini engeller, insülin salınımını uyarır, kardiyovasküler sistemde köpük hücre oluşumunu ve makrofajların kolesterol alımını inhibe eder, ayrıca vasküler düz kas hücrelerin proliferasyonunu azaltır, lenfositlerden salınan sitokinlerin inhibisyonu ile endotel hücrelerinde adezyon moleküllerinin üretimini baskılayarak ateroskleroz gelişimini engeller. Aynı zamanda vitamin D' nin aktif formu olan 1,25(OH)2D, renin seviyelerini baskılayarak antihipertansif etki gösterir. Vitamin D’nin endokrin ve kardiyovasküler sisteme olan bu etkileri göz önüne alındığında eksikliğinin pek çok hastalığa yol açabileceği düşünülmektedir. Son yıllarda yapılan çalışmalarda D vitamini eksikliğinin insulin direncini, metabolik sendrom riskini artırdığı, obezite, kanser, Tip 1, Tip 2 DM ve hipertansiyon gibi birçok hastalık için risk faktörü olduğu görülmektedir. Çalışma, D vitamini eksikliğinin obezite, diabetes mellitus, hipertansiyon ve kanser arasındaki ilişki üzerine mevcut literatürü gözden geçirmeyi hedeflemektedir.

Kaynakça

  • Fidan F, Alkan B M, Tosun A. Çağın Pandemisi: D vitamini eksikliği ve
  • yetersizliği. Türk Osteoporoz Dergisi 2014;20:71-4.
  • Wacker M, Holick M. Vitamin D-effects on skeletal and extraskeletal health
  • and the need for supplementation. Nutrients 2013;5(1):111-148.
  • Ataş A, Çakmak A, Soran M. Metabolism of Vitamin D and Rickets disease,
  • BTDMJB 2008;4(1):1-7.
  • Kulie T, Groff A, Redmer J, Hounshell J, Schrager S. Vitamin D: An Evidence-
  • Based Review. J Am Board Fam Med 2009; 22(6):698-706.
  • Tellioğlu A, Başaran S. Güncel bilgiler ışığında Vitamin D. Arşiv Kaynak
  • Tarama Dergisi 2013; 22(2): 259-271.
  • Djennane M, Lebbah S, Roux C, Souberbielle J, Djoudi H, Cavalier E. Vitamin
  • D status of schoolchildren in Northern Algeria, seasonal variations and
  • determinants of vitamin D deficiency. Osteoporos Int 2014; 25(5): 1493-
  • -
  • Grant WB, Holick MF. Benefits and requirements of vitamin D for optimal
  • health: A review. Altern Med Rev 2005; 10: 94-111.
  • Goh KS, Zhang D, Png GK, Lin H, Ang W, Low S, Lim J. Vitamin D Status
  • in Elderly Inpatients in a Tertiary Hospital in Singapore. J Am Geriatr Soc
  • ; 7:1398.
  • Grover SR, Morley R. Vitamin D deficiency in veiled or dark-skinned
  • pregnant women. Med J Aust 2001;5:251-252.
  • Kmie
  • Vitamin D deficiency during winter months among an adult, predominantly
  • urban, population in northern Poland. Endokrynol Pol 2014;65(2):105-113.
  • Pereira-Santos, Costa P, Santos C, Santos D. Obesity and vitamin D
  • deficiency: A systematic review and meta-analysis. Obes Rev 2015;16(4):
  • -349.
  • Bachhel R, Singh NR, Sidhu JS. Prevalence of vitamin D deficiency in northwest
  • Punjab population: A cross-sectional study. Int J App Basic Med Res
  • ;5(1):7-11.
  • Forman JP, Williams JS, Fisher NL. Plasma 25-Hydroxyvitamin D and
  • regulation of the renin-angiotensin system in humans. Hypertension 2010;
  • (5): 1283-1288.
  • Bilge U, Ünalacak M, Ünlüoglu I, Ipek M., Çeler Ö, Akalin A. Relationship
  • between 1,25-dihydroxy Vitamin D levels and homeostatic model
  • assessment insulin resistance values in obese subjects. Niger J Clin Pract
  • ;18(3):377-380.
  • Ghanei L, Ziaee A, Rostami P, Oveisi S, Esmailzadehha N, Kazemifar AM,
  • Zargar A. Association of serum 25-hydroxyvitamin d levels and vitamin d
  • dietary intake with metabolic syndrome: a case control study. J Res Health
  • Sci 2015; 15(1): 32-36.
  • Griz L, Bandeira F, Gabbay M, Dib S, de Carvalho E. Vitamin D and diabetes
  • mellitus: an update-2013. Arq Bras Endocrinol Metab 2014; 58(1):1-8.
  • Shi L, Nechuta S, Gao Y, Zheng Y, Dorjgochoo T, Wu J, Shu XO. Correlates
  • of 25-hydroxyvitamin D among Chinese breast cancer patients. Plos One
  • ; 9(1):
  • World Health Organization. Obesity and overweight. http://www.who.int/
  • mediacentre/factsheets/fs311/en/ erişim tarihi: 05.10.2015.
  • Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of obesity in the
  • United States, 2009-2010. NCHS Data Brief. 2012;(82):1-8.
  • Satman I, Yilmaz T, Sengul A, Salman S, Salman F, Uygur S, Bastar
  • I, Tütüncü Y, Sargın M, Diççağ N, Karsıdag K, Kalaça S, Özcan C, King
  • H. Population-based study of diabetes and risk characteristics in Turkey:
  • results of the turkish diabetes epidemiology study (TURDEP). Diabetes Care
  • ;25:1551–6.
  • Abacı A. Kardiyovasküler risk faktörlerinin ülkemizdeki durumu. Arch Turk
  • Soc Cardiol 2011;39 Suppl 4:1-5.
  • Türkiye İstatistik Kurumu, Sağlık Araştırması 2012. http://www.tuik.gov.
  • tr/Kitap.do?metod=KitapDetay&KT_ID=1&KITAP_ID=223. erişim tarihi:
  • 08.2015.
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  • Türkiye Halk Sağlığı Kurumu Obezite, Diabet ve Metabolik Hastalıklar
  • Daire Başkanlığı. Obezitenin Nedenleri. http://beslenme.gov.tr/index.
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  • Pereira-Santos, Costa P, Santos C, Santos D. Obesity and vitamin D
  • deficiency: A systematic review and meta-analysis. Obes Rev 2015;16(4):
  • -349.
  • Zhang L, Wang S, Che X, Li X. Vitamin D and lung cancer risk: a
  • comprehensive review and meta-analysis. CELL PHYSIOL BIOCHEM
  • ;36(1): 299-305.
  • Saliba W, Barnett-Griness O, Rennert G. Obesity and association of serum
  • (OH)D levels with all-cause mortality. Calcif Tissue Int 2014;95(3):222-
  • -
  • González L, Ramos-Trautmann G, Díaz-Luquis GM, Pérez CM, Palacios C.
  • Vitamin D status is inversely associated with obesity in a clinic-based sample
  • in Puerto Rico. Nutrition Research 2015;35(4):287-293.
  • Heller JE, Thomas JJ, Hollis, BW, Larson-Meyer DE. Relation between
  • vitamin D status and body composition in collegiate athletes. Int J Sport
  • Nutr Exerc Metab 2015;25(2):128-135.
  • Bhatt SP, Misra A, Sharma M, Guleria R, Pandey RM, Luthra K, Vikram NK.
  • (). Vitamin D insufficiency is associated with abdominal obesity in Urban
  • Asian Indians without diabetes in North India. Diabetes Technol Ther 2014;
  • (6):392-397.
  • Marcotorchino J, Tourniaire F, Astier J, Karkeni E, Canault M, Amiot MJ,
  • Bendahan D, Bernard M, Martin JC, Giannesini B, Landrier JF. Vitamin D
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  • Nutr Biochem 2014;25(10):1077-83.
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D Vitaminin Obezite, Diabetes Mellitus, Hipertansiyon ve Kanser İle İlişkisi

Yıl 2015, Cilt: 1 Sayı: 4, 143 - 149, 18.12.2015

Öz

Vitamin D is a group of sterols that regulate calcium and phosphorus metabolisma are one of the fat-soluble vitamins and among hormones and hormone precursors produced in the
body unlike the other vitamins. Vitamin D is reported to have an effect not only on bone, kidney, and intestine, but also on many organs such as brain, prostate, breast, colon, pancreas,
immune cells, muscles, and including myocardium and endothelium. Vitamin D prevents the damage of cells caused by cytokines in the pancreason Beta cells, stimulates insulin secretion,
inhibits formation of the foam cell in the cardiovascular system and the cholesterol intake of macrophages, and also reduces the proliferation of vascular smooth muscle cells,and inhibits
the development of atherosclerosis by suppressing the production of adhesion molecules in endothelial cells with the inhibition of cytokines released from lymphocytes. At the same
time, 1,25(OH)2D,which is the active form of vitamin D shows an antihypertensive effect by suppressing the levels of renin. Upon taking those effects of vitamin D on endocrine and
cardiovascular systems into account, a lack of it is thought to lead to many health problems. Studies having been conducted in recent years show that vitamin D deficiency increases
insulin resistance and the risk of metabolic syndrome and seems to be a risk factor for many diseases such as obesity, cancer, Type1, Type 2 Diabetes Mellitus (DM) and hypertension.
Our study aims to review existing literature on relationship between vitamin D deficiency and obesity, diabetes mellitus , hypertension and cancer

Kaynakça

  • Fidan F, Alkan B M, Tosun A. Çağın Pandemisi: D vitamini eksikliği ve
  • yetersizliği. Türk Osteoporoz Dergisi 2014;20:71-4.
  • Wacker M, Holick M. Vitamin D-effects on skeletal and extraskeletal health
  • and the need for supplementation. Nutrients 2013;5(1):111-148.
  • Ataş A, Çakmak A, Soran M. Metabolism of Vitamin D and Rickets disease,
  • BTDMJB 2008;4(1):1-7.
  • Kulie T, Groff A, Redmer J, Hounshell J, Schrager S. Vitamin D: An Evidence-
  • Based Review. J Am Board Fam Med 2009; 22(6):698-706.
  • Tellioğlu A, Başaran S. Güncel bilgiler ışığında Vitamin D. Arşiv Kaynak
  • Tarama Dergisi 2013; 22(2): 259-271.
  • Djennane M, Lebbah S, Roux C, Souberbielle J, Djoudi H, Cavalier E. Vitamin
  • D status of schoolchildren in Northern Algeria, seasonal variations and
  • determinants of vitamin D deficiency. Osteoporos Int 2014; 25(5): 1493-
  • -
  • Grant WB, Holick MF. Benefits and requirements of vitamin D for optimal
  • health: A review. Altern Med Rev 2005; 10: 94-111.
  • Goh KS, Zhang D, Png GK, Lin H, Ang W, Low S, Lim J. Vitamin D Status
  • in Elderly Inpatients in a Tertiary Hospital in Singapore. J Am Geriatr Soc
  • ; 7:1398.
  • Grover SR, Morley R. Vitamin D deficiency in veiled or dark-skinned
  • pregnant women. Med J Aust 2001;5:251-252.
  • Kmie
  • Vitamin D deficiency during winter months among an adult, predominantly
  • urban, population in northern Poland. Endokrynol Pol 2014;65(2):105-113.
  • Pereira-Santos, Costa P, Santos C, Santos D. Obesity and vitamin D
  • deficiency: A systematic review and meta-analysis. Obes Rev 2015;16(4):
  • -349.
  • Bachhel R, Singh NR, Sidhu JS. Prevalence of vitamin D deficiency in northwest
  • Punjab population: A cross-sectional study. Int J App Basic Med Res
  • ;5(1):7-11.
  • Forman JP, Williams JS, Fisher NL. Plasma 25-Hydroxyvitamin D and
  • regulation of the renin-angiotensin system in humans. Hypertension 2010;
  • (5): 1283-1288.
  • Bilge U, Ünalacak M, Ünlüoglu I, Ipek M., Çeler Ö, Akalin A. Relationship
  • between 1,25-dihydroxy Vitamin D levels and homeostatic model
  • assessment insulin resistance values in obese subjects. Niger J Clin Pract
  • ;18(3):377-380.
  • Ghanei L, Ziaee A, Rostami P, Oveisi S, Esmailzadehha N, Kazemifar AM,
  • Zargar A. Association of serum 25-hydroxyvitamin d levels and vitamin d
  • dietary intake with metabolic syndrome: a case control study. J Res Health
  • Sci 2015; 15(1): 32-36.
  • Griz L, Bandeira F, Gabbay M, Dib S, de Carvalho E. Vitamin D and diabetes
  • mellitus: an update-2013. Arq Bras Endocrinol Metab 2014; 58(1):1-8.
  • Shi L, Nechuta S, Gao Y, Zheng Y, Dorjgochoo T, Wu J, Shu XO. Correlates
  • of 25-hydroxyvitamin D among Chinese breast cancer patients. Plos One
  • ; 9(1):
  • World Health Organization. Obesity and overweight. http://www.who.int/
  • mediacentre/factsheets/fs311/en/ erişim tarihi: 05.10.2015.
  • Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of obesity in the
  • United States, 2009-2010. NCHS Data Brief. 2012;(82):1-8.
  • Satman I, Yilmaz T, Sengul A, Salman S, Salman F, Uygur S, Bastar
  • I, Tütüncü Y, Sargın M, Diççağ N, Karsıdag K, Kalaça S, Özcan C, King
  • H. Population-based study of diabetes and risk characteristics in Turkey:
  • results of the turkish diabetes epidemiology study (TURDEP). Diabetes Care
  • ;25:1551–6.
  • Abacı A. Kardiyovasküler risk faktörlerinin ülkemizdeki durumu. Arch Turk
  • Soc Cardiol 2011;39 Suppl 4:1-5.
  • Türkiye İstatistik Kurumu, Sağlık Araştırması 2012. http://www.tuik.gov.
  • tr/Kitap.do?metod=KitapDetay&KT_ID=1&KITAP_ID=223. erişim tarihi:
  • 08.2015.
  • T.C.Sağlık Bakanlığı Türkiye Halk Sağlığı Kurumu Türkiye Sağlıklı Beslenme
  • ve Hareketli Hayat Programı 2014-2017. http://diyabet.gov.tr/content/
  • files/yayinlar/kitaplar/turkiye_sagliklibeslenme_ve_hareketli_hayat_
  • programi.2014_2017.pdf erişim tarihi: 17.07.2015.
  • Türkiye Halk Sağlığı Kurumu Obezite, Diabet ve Metabolik Hastalıklar
  • Daire Başkanlığı. Obezitenin Nedenleri. http://beslenme.gov.tr/index.
  • php?lang=tr&page=41 erişim tarihi: 25.09.2015.
  • Pereira-Santos, Costa P, Santos C, Santos D. Obesity and vitamin D
  • deficiency: A systematic review and meta-analysis. Obes Rev 2015;16(4):
  • -349.
  • Zhang L, Wang S, Che X, Li X. Vitamin D and lung cancer risk: a
  • comprehensive review and meta-analysis. CELL PHYSIOL BIOCHEM
  • ;36(1): 299-305.
  • Saliba W, Barnett-Griness O, Rennert G. Obesity and association of serum
  • (OH)D levels with all-cause mortality. Calcif Tissue Int 2014;95(3):222-
  • -
  • González L, Ramos-Trautmann G, Díaz-Luquis GM, Pérez CM, Palacios C.
  • Vitamin D status is inversely associated with obesity in a clinic-based sample
  • in Puerto Rico. Nutrition Research 2015;35(4):287-293.
  • Heller JE, Thomas JJ, Hollis, BW, Larson-Meyer DE. Relation between
  • vitamin D status and body composition in collegiate athletes. Int J Sport
  • Nutr Exerc Metab 2015;25(2):128-135.
  • Bhatt SP, Misra A, Sharma M, Guleria R, Pandey RM, Luthra K, Vikram NK.
  • (). Vitamin D insufficiency is associated with abdominal obesity in Urban
  • Asian Indians without diabetes in North India. Diabetes Technol Ther 2014;
  • (6):392-397.
  • Marcotorchino J, Tourniaire F, Astier J, Karkeni E, Canault M, Amiot MJ,
  • Bendahan D, Bernard M, Martin JC, Giannesini B, Landrier JF. Vitamin D
  • protects against diet-induced obesity by enhancing fatty acid oxidation. J
  • Nutr Biochem 2014;25(10):1077-83.
  • Grønborg IM., Lundby IM., Mølgaard C, Jakobsen J, Ovesen L, Andersen R.
  • (). Association of body fat and vitamin D status and the effect of body fat
  • on the response to vitamin D supplementation in Pakistani immigrants in
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  • incelenmesi. Gulhane Med J 201153(4):271-276.
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  • risk of colorectal cancer. N Engl J Med 2006;354(7):684-696.
Toplam 201 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Makaleler
Yazarlar

Havva Sert Bu kişi benim

Serap Çetinkaya Bu kişi benim

Dilek Aygin Bu kişi benim

Yayımlanma Tarihi 18 Aralık 2015
Gönderilme Tarihi 18 Aralık 2015
Yayımlandığı Sayı Yıl 2015 Cilt: 1 Sayı: 4

Kaynak Göster

APA Sert, H., Çetinkaya, S., & Aygin, D. (2015). D Vitaminin Obezite, Diabetes Mellitus, Hipertansiyon ve Kanser İle İlişkisi. Journal of Human Rhythm, 1(4), 143-149.
AMA Sert H, Çetinkaya S, Aygin D. D Vitaminin Obezite, Diabetes Mellitus, Hipertansiyon ve Kanser İle İlişkisi. Journal of Human Rhythm. Aralık 2015;1(4):143-149.
Chicago Sert, Havva, Serap Çetinkaya, ve Dilek Aygin. “D Vitaminin Obezite, Diabetes Mellitus, Hipertansiyon Ve Kanser İle İlişkisi”. Journal of Human Rhythm 1, sy. 4 (Aralık 2015): 143-49.
EndNote Sert H, Çetinkaya S, Aygin D (01 Aralık 2015) D Vitaminin Obezite, Diabetes Mellitus, Hipertansiyon ve Kanser İle İlişkisi. Journal of Human Rhythm 1 4 143–149.
IEEE H. Sert, S. Çetinkaya, ve D. Aygin, “D Vitaminin Obezite, Diabetes Mellitus, Hipertansiyon ve Kanser İle İlişkisi”, Journal of Human Rhythm, c. 1, sy. 4, ss. 143–149, 2015.
ISNAD Sert, Havva vd. “D Vitaminin Obezite, Diabetes Mellitus, Hipertansiyon Ve Kanser İle İlişkisi”. Journal of Human Rhythm 1/4 (Aralık 2015), 143-149.
JAMA Sert H, Çetinkaya S, Aygin D. D Vitaminin Obezite, Diabetes Mellitus, Hipertansiyon ve Kanser İle İlişkisi. Journal of Human Rhythm. 2015;1:143–149.
MLA Sert, Havva vd. “D Vitaminin Obezite, Diabetes Mellitus, Hipertansiyon Ve Kanser İle İlişkisi”. Journal of Human Rhythm, c. 1, sy. 4, 2015, ss. 143-9.
Vancouver Sert H, Çetinkaya S, Aygin D. D Vitaminin Obezite, Diabetes Mellitus, Hipertansiyon ve Kanser İle İlişkisi. Journal of Human Rhythm. 2015;1(4):143-9.