Yıl 2016,
Cilt: 2 Sayı: 2, 0 - 0, 29.06.2016
Öz
Metotreksat antineoplastik hastalıkların ve romatoid artrit gibi kronik inflamatuvar hastalıkların tedavisinde kullanılan
folik asid antagonistidir. Metotreksat pansitopeni gibi şiddetli yan etkiler yapabilir. Bu istenmeyen yan etkiler genelde
yüksek doz metotreksat tedavisinde ortaya çıkar. Düşük doz metotreksat kullanımına bağlı gelişen pansitopenihayatı
tehdit edicidir. Romotoid artrit tedavi için düşük doz metotreksat kullanımı sonrasında pamsitopeni gelişen 71 yaşında
kadın hastayı sunmayı amaçladık.
Anahtar Kelimeler: Romatoid artrit, Metotreksat, Pansitopeni
Kaynakça
- Lim AYN, Gaffney K, Scott DGI. Methotrexate-induced pancytopenia:
- serious and under-reported? Our experience of 25 cases 5 years.
- Rheumatology 2005;44:1051-5.
- Ohosone Y, Okano Y, Kameda H, et al. Toxicity of low-dose methotrexate
- in rheumatoid arthritis –clinical characteristics in patients with MTX-induced
- pancytopenia and interstitial pneumonitis. Ryumachi 1997; 37(1):16-23.
- Guler N, Kisacik B, Utku U, et al. Low dose methotrexate associated
- pancytopenia in a patient with rheumatoid arthritis. Turk J Phys Med Rehab
- ;54:79-81.
- Cronstein, B. N. (2005). Low-Dose Methotrexate: A Mainstay in the
- Treatment of Rheumatoid Arthritis. Pharmacological Reviews 2005; 57 (2):
- –172.
- Nakazaki S, Muruyama T, Katoh S. Cytopenia associated with low dose
- pulse methotrexate in the treatment of rheumatoid arthritis. Ryumachi
- ;41(6):929-37.
- S. Gutierrez-Urena, J. F. Molina, C. O. Garcia, et al. Pancytopenia secondary
- to MTX therapy in rheumatoid arthritis. Arthritis and Rheumatism. 1996;39:
- –276.
- Therapeutic Information Resources Australia. Calcium Folinate in AUSDI:
- Australian Drug Information for the Health Care Professional. Castle Hill:
- Therapeutic Information Resources Australia.2004
- Beveridge R A, Miller J A, Kales A N, et al. A Comparison of Efficacy of
- Sargramostim (Yeast-Derived RhuGM-CSF) and Filgrastim (Bacteria-
- Derived RhuG-CSF) in the Therapeutic Setting of Chemotherapy-Induced
- Myelosuppression. Cancer Investigation 1998. 16 (6): 366–373.
Yıl 2016,
Cilt: 2 Sayı: 2, 0 - 0, 29.06.2016
Öz
Kaynakça
- Lim AYN, Gaffney K, Scott DGI. Methotrexate-induced pancytopenia:
- serious and under-reported? Our experience of 25 cases 5 years.
- Rheumatology 2005;44:1051-5.
- Ohosone Y, Okano Y, Kameda H, et al. Toxicity of low-dose methotrexate
- in rheumatoid arthritis –clinical characteristics in patients with MTX-induced
- pancytopenia and interstitial pneumonitis. Ryumachi 1997; 37(1):16-23.
- Guler N, Kisacik B, Utku U, et al. Low dose methotrexate associated
- pancytopenia in a patient with rheumatoid arthritis. Turk J Phys Med Rehab
- ;54:79-81.
- Cronstein, B. N. (2005). Low-Dose Methotrexate: A Mainstay in the
- Treatment of Rheumatoid Arthritis. Pharmacological Reviews 2005; 57 (2):
- –172.
- Nakazaki S, Muruyama T, Katoh S. Cytopenia associated with low dose
- pulse methotrexate in the treatment of rheumatoid arthritis. Ryumachi
- ;41(6):929-37.
- S. Gutierrez-Urena, J. F. Molina, C. O. Garcia, et al. Pancytopenia secondary
- to MTX therapy in rheumatoid arthritis. Arthritis and Rheumatism. 1996;39:
- –276.
- Therapeutic Information Resources Australia. Calcium Folinate in AUSDI:
- Australian Drug Information for the Health Care Professional. Castle Hill:
- Therapeutic Information Resources Australia.2004
- Beveridge R A, Miller J A, Kales A N, et al. A Comparison of Efficacy of
- Sargramostim (Yeast-Derived RhuGM-CSF) and Filgrastim (Bacteria-
- Derived RhuG-CSF) in the Therapeutic Setting of Chemotherapy-Induced
- Myelosuppression. Cancer Investigation 1998. 16 (6): 366–373.
Toplam 25 adet kaynakça vardır.
Ayrıntılar
| Bölüm | Makaleler |
|---|---|
| Yazarlar | |
| Yayımlanma Tarihi | 29 Haziran 2016 |
| Gönderilme Tarihi | 29 Haziran 2016 |
| Yayımlandığı Sayı | Yıl 2016 Cilt: 2 Sayı: 2 |