Araştırma Makalesi
BibTex RIS Kaynak Göster

Serum Endocan and Procalcitonin Levels in Determining The Severity of Acute Pancreatitis

Yıl 2018, Cilt: 4 Sayı: 2, 111 - 116, 29.06.2018

Hatice Beyazal Polat Medeni Arpa Mehmet Beyazal Teslime Ayaz Fatma Betazal Filiz Mercantepe M. Ali Ayvaz Halil Rakıcı A. Remzi Akdoğan

Öz

Skorlama sistemleri ve görüntüleme yöntemleri, akut pankreatitin (AP) şiddetini belirlemede yeterli bilgi sağlayamayabilir, diğer

parametrelere ihtiyaç vardır. İnfl amasyon akut pankreatit patogenezinde önemlibir rol oynar ve infl amasyon belirteçleri AP şiddetinin

belirlenmesinde önemli olabilir.

Yöntem İlk AP atağı olan ardışık 52 yetişkin hasta (> 18 yaş) prospektif olarak çalışmaya dahil edildi. Akut pankreatit ciddiyeti Revize Atlanta

kriterlerine göre belirlendi. Dolaşımdaki endokan ve prokalsitonin (PCT) seviyeleri ELISA yöntemi kullanılarak ölçüldü.

Bulgular İlk AP tanısıalan 52 sıralı yetişkin hasta AP ciddiyetine göre; 25hasta hafi f- AP (% 48), 27'siorta – şiddetliAP (% 52) olmak üzere 2 gruba

ayrıldı. Ortalama hasta yaşı ve kadın cinsiyet oranı orta - şiddetli AP grubunda hafi f AP grubuna göre anlamlı derecede yüksekti (sırasıyla

p = 0.04 ve 0.02). Bununla birlikte, gruplar biyokimyasal parametreler açısından anlamlı farklılık göstermedi ve grupl ar arasında serum

prokalsitonin ve endokan düzeylerinde fark yoktu. Akut pankreatit ciddiyeti ile serum endokan ve prokalsitonin düzeyleri arasında

korelasyon yoktu.

Sonuç Serum endokan ve PCT düzeyleri, ciddi AP ve hafi f AP grupları arasında anlamlı bir farklılık göstermedi. Bu nedenle, bu belirteçler

AP'nin ciddiyetini belirlemek için ek fayda sağlamayabilir

Anahtar Kelimeler

akut pankreatit ciddiyet serum endokan ve prokalsitonin

Kaynakça

  • 1. Goldacre MJ, Roberts SE. Hospital admission for acute pancreatitis in an English population, 1963 – 98: database study of incidence and mortality . BMJ 2004 ; 328 : 1466 – 9.
  • 2. Gok M, Kundi H, Kiziltunc E, Topcuoglu C, Ornek E. Endocan Levels and Coronary Collateral Circulation in Stable Angina Pectoris: A Pilot Study. Angiology. 2017 Jan 1:3319717703835. doi: 10.1177/0003319717703835
  • 3. Bilir B, Ekiz Bilir B, Yilmaz I, et al. Association of apelin, endoglin and endocan with diabetic peripheral neuropathy in type 2 diabetic patients. Eur Rev Med PharmacolSci. 2016 Mar;20(5):892-8.
  • 4. Icli A, Cure E, Cure MC et al EndocanLevelsandSubclinicalAtherosclerosis in Patients With Systemic Lupus Erythematosus. Angiology. 2016 Sep;67(8):749-55.
  • 5. Prat C, Sancho JM, Dominguez J, et al. Evaluation of procalcitonin, neopterin, C-reactive protein, IL-6 and IL-8 as a diagnostic marker of infection in patients with febrile neutropenia. LeukLymphoma. 2008 Sep;49(9):1752-61.
  • 6. Mandi Y, Farkas G, Takacs T, Boda K, Lonovics J. Diagnostic relevance of procalcitonin, IL-6, and sICAM-1 in theprediction of infectednecrosis in acute pancreatitis. Int J Pancreatol 2000;28:41-9.
  • 7. Riché FC, Cholley BP, Laisné MJ, et al. Infl ammatory cytokines, C reactive protein, and procalcitonin as early predictors of necrosisinfection in acute necrotizing pancreatitis. Surgery. 2003 Mar;133(3):257-62.
  • 8. Olah A, Belagyi T, Issekutz A, Makay R, Zaborszky A. Value of procalcitonin quick test in the differentiation between sterile and infected forms of acute pancreatitis. Hepatogastroenterology 2005;52:243-5.
  • 9. Ammori BJ, Becker KL, Kite P, et al. Calcitonin precursors: early markers of gut barrier dysfunction in patients with acute pancreatitis. Pancreas. 2003 Oct;27(3):239-43.
  • 10. Danish Medical Health Authorities. Alkohol. Sundhedsstyrelsen, Danish. Availablefrom: http://www.sst.dk/.
  • 11. BanksPA , Freeman ML . Practice guidelines in acute pancreatitis .Am J Gastroenterol2006 ; 101 : 2379 – 400
  • 12. Werner J, Feuerbach S, Uhl W, Büchler MW. Management of acute pancreatitis: From surgery to interventional intensive care. Gut 2005;54:426- 36
  • 13. TennerS .Initial management of acute pancreatitis: critical decisions during the fi rst 72 hours .Am J Gastroenterol2004 ; 99 : 2489 – 94
  • 14. Balthazar EJ, Robinson DL, Megibow AJ, Ranson JH. Acute pancreatitis: value of CT in establishing prognosis. Radiology. 1990 Feb;174(2):331- 6.
  • 15. Bhatia M, Brady M, Shokuhi S, Christmas S, Neoptolemos JP, Slavin J: Inflammatory mediators in acute pancreatitis. J Pathol. 2000;190:117–125
  • 16. Bhatia M, Moochhala S: Role of infl ammatory mediators in the pathophysiology of acute respiratory distress syndrome. J Pathol 2004;202:145–156
  • 17. Bhatia M, Wong FL, Cao Y, et al. Pathophysiology of acute pancreatitis. Pancreatology 2005;5(2–3):132–144 18. Dominguez-Munoz JE, V illanuevaA , Larino J et al. Accuracy of plasma levels of polymorphonuclear elastase as early prognostic marker of acute pancreatitis in routine clinical conditions. Eur J GastroenterolHepatol2006 ; 18 : 79 – 83 .
  • 19. Dominguez-Munoz J E, CarballoF , Garcia M J , et al . Monitoring of serum proteinase–antiproteinase balance and systemic infl ammatory response in prognostic evaluation of acute pancreatitis .Results of a prospective multicenter study. DigDisSci1993 ; 38 : 507 – 13 .
  • 20. Novovic S, Andersen AM, Nord M, et al. Activity of neutrophil elastase refl ects the progression of acute pancreatitis. Scand J ClinLabInvest. 2013 Sep;73(6):485-93.

Yıl 2018, Cilt: 4 Sayı: 2, 111 - 116, 29.06.2018

Hatice Beyazal Polat Medeni Arpa Mehmet Beyazal Teslime Ayaz Fatma Betazal Filiz Mercantepe M. Ali Ayvaz Halil Rakıcı A. Remzi Akdoğan

Öz

Kaynakça

  • 1. Goldacre MJ, Roberts SE. Hospital admission for acute pancreatitis in an English population, 1963 – 98: database study of incidence and mortality . BMJ 2004 ; 328 : 1466 – 9.
  • 2. Gok M, Kundi H, Kiziltunc E, Topcuoglu C, Ornek E. Endocan Levels and Coronary Collateral Circulation in Stable Angina Pectoris: A Pilot Study. Angiology. 2017 Jan 1:3319717703835. doi: 10.1177/0003319717703835
  • 3. Bilir B, Ekiz Bilir B, Yilmaz I, et al. Association of apelin, endoglin and endocan with diabetic peripheral neuropathy in type 2 diabetic patients. Eur Rev Med PharmacolSci. 2016 Mar;20(5):892-8.
  • 4. Icli A, Cure E, Cure MC et al EndocanLevelsandSubclinicalAtherosclerosis in Patients With Systemic Lupus Erythematosus. Angiology. 2016 Sep;67(8):749-55.
  • 5. Prat C, Sancho JM, Dominguez J, et al. Evaluation of procalcitonin, neopterin, C-reactive protein, IL-6 and IL-8 as a diagnostic marker of infection in patients with febrile neutropenia. LeukLymphoma. 2008 Sep;49(9):1752-61.
  • 6. Mandi Y, Farkas G, Takacs T, Boda K, Lonovics J. Diagnostic relevance of procalcitonin, IL-6, and sICAM-1 in theprediction of infectednecrosis in acute pancreatitis. Int J Pancreatol 2000;28:41-9.
  • 7. Riché FC, Cholley BP, Laisné MJ, et al. Infl ammatory cytokines, C reactive protein, and procalcitonin as early predictors of necrosisinfection in acute necrotizing pancreatitis. Surgery. 2003 Mar;133(3):257-62.
  • 8. Olah A, Belagyi T, Issekutz A, Makay R, Zaborszky A. Value of procalcitonin quick test in the differentiation between sterile and infected forms of acute pancreatitis. Hepatogastroenterology 2005;52:243-5.
  • 9. Ammori BJ, Becker KL, Kite P, et al. Calcitonin precursors: early markers of gut barrier dysfunction in patients with acute pancreatitis. Pancreas. 2003 Oct;27(3):239-43.
  • 10. Danish Medical Health Authorities. Alkohol. Sundhedsstyrelsen, Danish. Availablefrom: http://www.sst.dk/.
  • 11. BanksPA , Freeman ML . Practice guidelines in acute pancreatitis .Am J Gastroenterol2006 ; 101 : 2379 – 400
  • 12. Werner J, Feuerbach S, Uhl W, Büchler MW. Management of acute pancreatitis: From surgery to interventional intensive care. Gut 2005;54:426- 36
  • 13. TennerS .Initial management of acute pancreatitis: critical decisions during the fi rst 72 hours .Am J Gastroenterol2004 ; 99 : 2489 – 94
  • 14. Balthazar EJ, Robinson DL, Megibow AJ, Ranson JH. Acute pancreatitis: value of CT in establishing prognosis. Radiology. 1990 Feb;174(2):331- 6.
  • 15. Bhatia M, Brady M, Shokuhi S, Christmas S, Neoptolemos JP, Slavin J: Inflammatory mediators in acute pancreatitis. J Pathol. 2000;190:117–125
  • 16. Bhatia M, Moochhala S: Role of infl ammatory mediators in the pathophysiology of acute respiratory distress syndrome. J Pathol 2004;202:145–156
  • 17. Bhatia M, Wong FL, Cao Y, et al. Pathophysiology of acute pancreatitis. Pancreatology 2005;5(2–3):132–144 18. Dominguez-Munoz JE, V illanuevaA , Larino J et al. Accuracy of plasma levels of polymorphonuclear elastase as early prognostic marker of acute pancreatitis in routine clinical conditions. Eur J GastroenterolHepatol2006 ; 18 : 79 – 83 .
  • 19. Dominguez-Munoz J E, CarballoF , Garcia M J , et al . Monitoring of serum proteinase–antiproteinase balance and systemic infl ammatory response in prognostic evaluation of acute pancreatitis .Results of a prospective multicenter study. DigDisSci1993 ; 38 : 507 – 13 .
  • 20. Novovic S, Andersen AM, Nord M, et al. Activity of neutrophil elastase refl ects the progression of acute pancreatitis. Scand J ClinLabInvest. 2013 Sep;73(6):485-93.
Toplam 19 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Makaleler
Yazarlar

Hatice Beyazal Polat Bu kişi benim

Medeni Arpa

Mehmet Beyazal Bu kişi benim

Teslime Ayaz

Fatma Betazal Bu kişi benim

Filiz Mercantepe Bu kişi benim

M. Ali Ayvaz Bu kişi benim

Halil Rakıcı Bu kişi benim

A. Remzi Akdoğan Bu kişi benim

Yayımlanma Tarihi 29 Haziran 2018
Gönderilme Tarihi 29 Mayıs 2018
Kabul Tarihi 27 Haziran 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 4 Sayı: 2

Kaynak Göster

APA Beyazal Polat, H., Arpa, M., Beyazal, M., Ayaz, T., vd. (2018). Serum Endocan and Procalcitonin Levels in Determining The Severity of Acute Pancreatitis. Journal of Human Rhythm, 4(2), 111-116.
AMA Beyazal Polat H, Arpa M, Beyazal M, Ayaz T, Betazal F, Mercantepe F, Ayvaz MA, Rakıcı H, Akdoğan AR. Serum Endocan and Procalcitonin Levels in Determining The Severity of Acute Pancreatitis. Journal of Human Rhythm. Haziran 2018;4(2):111-116.
Chicago Beyazal Polat, Hatice, Medeni Arpa, Mehmet Beyazal, Teslime Ayaz, Fatma Betazal, Filiz Mercantepe, M. Ali Ayvaz, Halil Rakıcı, ve A. Remzi Akdoğan. “Serum Endocan and Procalcitonin Levels in Determining The Severity of Acute Pancreatitis”. Journal of Human Rhythm 4, sy. 2 (Haziran 2018): 111-16.
EndNote Beyazal Polat H, Arpa M, Beyazal M, Ayaz T, Betazal F, Mercantepe F, Ayvaz MA, Rakıcı H, Akdoğan AR (01 Haziran 2018) Serum Endocan and Procalcitonin Levels in Determining The Severity of Acute Pancreatitis. Journal of Human Rhythm 4 2 111–116.
IEEE H. Beyazal Polat, “Serum Endocan and Procalcitonin Levels in Determining The Severity of Acute Pancreatitis”, Journal of Human Rhythm, c. 4, sy. 2, ss. 111–116, 2018.
ISNAD Beyazal Polat, Hatice vd. “Serum Endocan and Procalcitonin Levels in Determining The Severity of Acute Pancreatitis”. Journal of Human Rhythm 4/2 (Haziran 2018), 111-116.
JAMA Beyazal Polat H, Arpa M, Beyazal M, Ayaz T, Betazal F, Mercantepe F, Ayvaz MA, Rakıcı H, Akdoğan AR. Serum Endocan and Procalcitonin Levels in Determining The Severity of Acute Pancreatitis. Journal of Human Rhythm. 2018;4:111–116.
MLA Beyazal Polat, Hatice vd. “Serum Endocan and Procalcitonin Levels in Determining The Severity of Acute Pancreatitis”. Journal of Human Rhythm, c. 4, sy. 2, 2018, ss. 111-6.
Vancouver Beyazal Polat H, Arpa M, Beyazal M, Ayaz T, Betazal F, Mercantepe F, Ayvaz MA, Rakıcı H, Akdoğan AR. Serum Endocan and Procalcitonin Levels in Determining The Severity of Acute Pancreatitis. Journal of Human Rhythm. 2018;4(2):111-6.