ST yükselmeli miyokard enfarktüsünde serum ürik asit-HDL kolesterol oranının mortalitenin yeni bir belirleyicisi olarak değerlendirilmesi: kesitsel bir çalışma

Abstract

Giriş ve amaç: Bu çalışmanın amacı, ST-segment Yükselmeli Miyokard Enfarktüsü (STYME) geçiren hastalarda mortalite için yeni bir enflamatuar ve metabolik belirteç olarak Ürik Asit-Yüksek Dansiteli Lipoprotein Kolesterol Oranının (ÜHO) öngörücü etkinliğini değerlendirmektir. Yöntemler: Bu retrospektif, tek merkezli, kesitsel, gözlemsel çalışmaya Mart 2021 ile Ocak 2022 tarihleri arasında primer perkütan koroner girişim (PPKG) uygulanan STYMI tanılı 1361 hasta dahil edilmiştir. Katılımcılar iki gruba ayrılmıştır: hastane-içi mortalite gerçekleşen (n=100) ve gerçekleşmeyen (n=1265). Sonuçlar: Hastane-içi mortalite 100 hastada (%7.3) meydana gelmiştir. ÜHO, mortalite grubunda mortalite olmayan gruba kıyasla belirgin şekilde daha yüksekti (%23.6±14.9'a karşı %15.3±6.9, p<0.001). Lojistik regresyon analizi, STYMI hastaları arasında hastane-içi mortalitenin birkaç bağımsız belirleyicisi tanımlanmıştır, yaş (risk oranı [RO]=1.050, p<0.001), DM varlığı (RO=2. 077, p=0.016), serum glukozu (RO=1.004, p=0.002), hemoglobin (RO=0.855, p=0.020), beyaz kan hücresi sayısı (RO=1.064, p=0.025), ÜHO (RO=1.683, p<0.001) ve SYNTAX skoru (R0=1.099, p<0.001). Alıcı işletim karakteristik eğrisi analizi, ÜHO> %13.9' un PPKG uygulanan STYMI hastalarında hastane içi mortaliteyi %81.1 duyarlılık ve %49.2 özgüllükle belirlediğini ortaya koymuştur (EAA=0.668, p=0.001) Sonuçlar: ÜHO, PPKGI uygulanan STYMI hastaları arasında hastane-içi mortalite ile anlamlı ve bağımsız bir pozitif korelasyon sergilemiştir.

Keywords

• Ürik Asit
• HDL-K
• Ürik Asit-Yüksek Dansiteli Lipoprotein Kolesterol Oranı
• STYMI
• SYNTAX skoru
• Hastane-içi mortalite

The assessment of serum uric acid-to-HDL cholesterol ratio as a new predictor of mortality in ST-elevation myocardial infarction: a cross-sectional study

Abstract

Aims: The objective of this study was to evaluate the predictive efficacy of the Uric Acid-to-High Density Lipoprotein Cholesterol Ratio (UHR) as a novel inflammatory and metabolic marker for mortality in patients with ST-segment Elevation Myocardial Infarction (STEMI). Methods: This retrospective, single-center, cross-sectional, observational study enrolled 1361 patients diagnosed with STEMI undergoing primary percutaneous coronary intervention (PPCI) from March 2021, to January 2022. The participants were categorized into two groups: those experiencing in-hospital mortality (n=100) and those without in-hospital mortality (n=1265). Results: In-hospital mortality occurred in 100 patients (7.3%). UHR was notably higher in the mortality group compared to the non-mortality group (23.6±14.9% vs. 15.3±6.9%, p<0.001). Logistic regression analysis identified several independent determinants of in-hospital mortality among STEMI patients, including age (odds ratio [OR]=1.050, p<0.001), the presence of DM (OR=2.077, p=0.016), serum glucose (OR=1.004, p=0.002), hemoglobin (OR=0.855, p=0.020), White blood cell count (OR=1.064, p=0.025), UHR (OR=1.683, p<0.001), and SYNTAX score (OR=1.099, p<0.001). Receiver operating characteristic curve analysis revealed that UHR>13.9% determined in-hospital mortality in STEMI patients who underwent PPCI with 81.1% sensitivity and 49.2% specificity (AUC=0.668, p=0.001) Conclusion: The UHR exhibited a significant and independent positive correlation with in-hospital mortality among STEMI patients undergoing PPCI.

Keywords

• Uric acid
• HDL-C
• uric acid-to-high density lipoprotein cholesterol ratio
• STEMI
• SYNTAX score
• in-hospital mortality

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