Sistemik immun-inflamatuar indeks alzheimer hastalığının tanısı ve takibi için yeni bir gösterge olabilir mi?

Öz

Amaç: Tanısı ve takibinde kullanılan ideal bir biyobelirteç olmayan Alzheimer hastalığı (AH), prevalansı ileri yaş popülasyonunda artmaya devam eden kronik bir nörodejeneratif hastalıktır. Nötrofil /lenfosit oranın (NLR) AH’da normal popülasyona göre artmış olduğu gösterilmiştir. Ancak periferik platelet sayısı X nötrofil sayısı/ lenfosit sayısı formülüne göre hesaplanan sistemik immun-inflamatuar indeks (SII)’in AH’ndaki yeri ile ilgili literatürde henüz bir çalışma bulunmamaktadır. Bu nedenle bu çalışmadaki amacımız AH’nın teşhis ve takibinde NLR ile kıyaslayarak SII’nin yerini ortaya koymak ve bu değerin hastalığın ciddiyeti, süresi ve ilaç kullanımı ile ilişkisini tespit etmektir.

Materyal ve Metot: Retrospektif olarak dizayn edilmiş çalışmamıza kliniğimize başvurmuş, alınan anamnez ve yapılan nörolojik muayene ile AH tanısı konulmuş 102 hasta ile hasta grubumuza benzer yaş ve cinsiyete sahip 94 gönüllü dahil edildi.

Bulgular: Hasta ve kontrol grubu arasında yaş, cinsiyet, platelet ve nötrofil sayıları ve SII değerleri açısından fark yoktu. Lenfosit sayısı hasta grupta daha düşükken; NLR ve CRP düzeyi daha yüksek olarak tespit edildi (sırasıyla p=0.001, p=0.001, p=0.001). SII hem hastalık süresi hem de ciddiyeti arttıkça artmaktayken; NLR ile hastalığın ciddiyeti, süresi ve ilaç kullanımı arasında istatistiksel olarak anlamlı ilişki saptanmadı.

Sonuç: Çalışmamızın verilerine dayanarak AH’da her aşamada inflamatuar sürecin arttığı öne sürülebilir. Ancak bu durumun hastalığın ciddiyeti, süresi ve ilaç kullanımı ile ilişkisi henüz bilinmemektedir.

Anahtar Kelimeler

• Nötrofil/Lenfosit Oranı
• Sistemik İmmün-İnflamatuar İndeks
• İnflamasyon
• Alzheimer hastalığı

Can the systemic immune-inflammatory index be a new indicator for the diagnosis and follow-up of alzheimer's disease?

Öz

Background: Alzheimer's disease (AD) is a chronic neurodegenerative disease whose prevalence continues to increase in the elderly population. It has been shown that the neutrophil/lymphocyte ratio (NLR), is increased in AD compared to the normal population. However, there is no study in the literature regarding the role of systemic immune-inflammatory index (SII), which is calculated according to the formula of peripheral platelet count X neutrophil count/lymphocyte count, in AD. Therefore, our aim in this study was to reveal the role of SII in the diagnosis and follow-up of AD and to determine the relationship of this value with severity, duration of disease and drug use by comparing it with NLR.
Materials and Methods: Our retrospective study consisted of 94 gender and age matched healthy volunteers and 102 patients who applied to our clinic were diagnosed with AD.
Results: There was no difference between the patient and control groups in terms of age, gender, platelet and neutrophil counts, and SII values. While lymphocyte count was lower in-patient group; NLR and CRP detected higher (p=0.001, p=0.001, p=0.001, respectively). While SII increased as both disease duration and severity elevated; no statistically significant correlation was found between NLR and the severity and duration of the disease and drug use.
Conclusions: Based on the data of our study, we can suggest that inflammatory process increases in AD. However, the relationship of this inflammatory process with the severity and duration of the disease and drug use is still unknown.

Anahtar Kelimeler

• Neutropil/Lymphocyte Ratio
• Systemic Immune-Inflamatory Index
• Inflamation
• Alzheimer Disease

Kaynakça

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